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PCYOX1 prenylcysteine oxidase 1 [ Homo sapiens (human) ]

Gene ID: 51449, updated on 24-Nov-2020

Summary

Official Symbol
PCYOX1provided by HGNC
Official Full Name
prenylcysteine oxidase 1provided by HGNC
Primary source
HGNC:HGNC:20588
See related
Ensembl:ENSG00000116005 MIM:610995
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PCL1
Summary
Prenylcysteine is released during the degradation of prenylated proteins. PCYOX1 catalyzes the degradation of prenylcysteine to yield free cysteines and a hydrophobic isoprenoid product (Tschantz et al., 1999 [PubMed 10585463]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in fat (RPKM 61.1), kidney (RPKM 49.9) and 23 other tissues See more
Orthologs

Genomic context

See PCYOX1 in Genome Data Viewer
Location:
2p13.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (70258137..70281185)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (70485231..70508317)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene microRNA 1285-2 Neighboring gene ribosomal protein L39 pseudogene 15 Neighboring gene small nuclear ribonucleoprotein polypeptide G Neighboring gene family with sequence similarity 136 member A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

Associated conditions

Description Tests
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0908

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATPase-coupled chloride transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
prenylcysteine oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
prenylcysteine oxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
chloride transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
prenylated protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
prenylated protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
prenylated protein catabolic process NAS
Non-traceable Author Statement
more info
PubMed 
prenylcysteine catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular exosome HDA PubMed 
lysosome IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
very-low-density lipoprotein particle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
prenylcysteine oxidase 1
Names
prenylcysteine lyase
NP_057381.3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016297.4NP_057381.3  prenylcysteine oxidase 1 precursor

    See identical proteins and their annotated locations for NP_057381.3

    Status: VALIDATED

    Source sequence(s)
    AC079338, AY359063, DC417137
    Consensus CDS
    CCDS1902.1
    UniProtKB/Swiss-Prot
    Q9UHG3
    Related
    ENSP00000387654.2, ENST00000433351.7
    Conserved Domains (2) summary
    pfam07156
    Location:130494
    Prenylcys_lyase; Prenylcysteine lyase
    cl27535
    Location:48108
    Amino_oxidase; Flavin containing amine oxidoreductase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    70258137..70281185
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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