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PCYOX1 prenylcysteine oxidase 1 [ Homo sapiens (human) ]

Gene ID: 51449, updated on 19-Sep-2024

Summary

Official Symbol
PCYOX1provided by HGNC
Official Full Name
prenylcysteine oxidase 1provided by HGNC
Primary source
HGNC:HGNC:20588
See related
Ensembl:ENSG00000116005 MIM:610995; AllianceGenome:HGNC:20588
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PCL1
Summary
Prenylcysteine is released during the degradation of prenylated proteins. PCYOX1 catalyzes the degradation of prenylcysteine to yield free cysteines and a hydrophobic isoprenoid product (Tschantz et al., 1999 [PubMed 10585463]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in fat (RPKM 61.1), kidney (RPKM 49.9) and 23 other tissues See more
Orthologs
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Genomic context

See PCYOX1 in Genome Data Viewer
Location:
2p13.3
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (70257915..70281185)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (70269656..70292921)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (70485269..70508317)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene microRNA 1285-2 Neighboring gene ribosomal protein L39 pseudogene 15 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11609 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11610 Neighboring gene small nuclear ribonucleoprotein polypeptide G Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:70519630-70520537 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16007 Neighboring gene uncharacterized LOC124906023 Neighboring gene family with sequence similarity 136 member A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA0908

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables FAD binding IDA
Inferred from Direct Assay
more info
PubMed 
enables farnesylcysteine lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables prenylcysteine oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables prenylcysteine oxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in prenylated protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in prenylated protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in prenylated protein catabolic process NAS
Non-traceable Author Statement
more info
PubMed 
involved_in prenylcysteine catabolic process IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
prenylcysteine oxidase 1
Names
prenylcysteine lyase
NP_057381.3
XP_047300645.1
XP_054198442.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016297.4NP_057381.3  prenylcysteine oxidase 1 precursor

    See identical proteins and their annotated locations for NP_057381.3

    Status: VALIDATED

    Source sequence(s)
    AC079338, AY359063, DC417137
    Consensus CDS
    CCDS1902.1
    UniProtKB/Swiss-Prot
    B2RB14, B7Z9P8, O94982, Q8N4N5, Q96QM8, Q9UHG3
    UniProtKB/TrEMBL
    B7Z8A2
    Related
    ENSP00000387654.2, ENST00000433351.7
    Conserved Domains (2) summary
    pfam07156
    Location:130494
    Prenylcys_lyase; Prenylcysteine lyase
    cl27535
    Location:48108
    Amino_oxidase; Flavin containing amine oxidoreductase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    70257915..70281185
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047444689.1XP_047300645.1  prenylcysteine oxidase 1 isoform X1

    UniProtKB/TrEMBL
    B7Z3Y2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    70269656..70292921
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054342467.1XP_054198442.1  prenylcysteine oxidase 1 isoform X1

    UniProtKB/TrEMBL
    B7Z3Y2