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RNF138 ring finger protein 138 [ Homo sapiens (human) ]

Gene ID: 51444, updated on 13-Mar-2020

Summary

Official Symbol
RNF138provided by HGNC
Official Full Name
ring finger protein 138provided by HGNC
Primary source
HGNC:HGNC:17765
See related
Ensembl:ENSG00000134758 MIM:616319
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NARF; HSD-4; STRIN; hNARF
Summary
The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 31.9), bone marrow (RPKM 30.7) and 23 other tissues See more
Orthologs

Genomic context

See RNF138 in Genome Data Viewer
Location:
18q12.1
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 18 NC_000018.10 (32091858..32131561)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (29671818..29711524)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene ring finger protein 125 Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 44 Neighboring gene ribosomal protein S15a pseudogene 35 Neighboring gene RNA, 5S ribosomal pseudogene 453 Neighboring gene meprin A subunit beta Neighboring gene clustered mitochondria homolog pseudogene 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC8758

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
single-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin protein ligase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
DNA double-strand break processing involved in repair via single-strand annealing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA double-strand break processing involved in repair via single-strand annealing IMP
Inferred from Mutant Phenotype
more info
PubMed 
Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
cellular response to leukemia inhibitory factor IEA
Inferred from Electronic Annotation
more info
 
double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
double-strand break repair via homologous recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
nucleus HDA PubMed 
site of double-strand break IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
site of double-strand break IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
E3 ubiquitin-protein ligase RNF138
Names
NLK-associated RING finger protein
Nemo-like kinase-associated RING finger protein
RING-type E3 ubiquitin transferase RNF138
nemo-like kinase associated ring finger protein
ring finger protein 138, E3 ubiquitin protein ligase
testicular tissue protein Li 165
NP_001178253.2
NP_057355.2
NP_937761.1
XP_005258342.1
XP_005258343.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029944.1 RefSeqGene

    Range
    5020..44707
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001191324.1NP_001178253.2  E3 ubiquitin-protein ligase RNF138 isoform 1

    See identical proteins and their annotated locations for NP_001178253.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 and 3 encode the same protein (isoform 1).
    Source sequence(s)
    AK023579, BC018107, DA752192, DB091985
    Consensus CDS
    CCDS11903.1
    UniProtKB/Swiss-Prot
    Q8WVD3
    UniProtKB/TrEMBL
    A0A140VJT9
    Conserved Domains (2) summary
    pfam05605
    Location:156215
    zf-Di19; Drought induced 19 protein (Di19), zinc-binding
    cd16544
    Location:1459
    RING-HC_RNF138; RING finger, HC subclass, found in RING finger protein 138 (RNF138) and similar proteins
  2. NM_016271.5NP_057355.2  E3 ubiquitin-protein ligase RNF138 isoform 1

    See identical proteins and their annotated locations for NP_057355.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 3 encode the same protein (isoform 1).
    Source sequence(s)
    AC011825, BC018107, DB452430
    Consensus CDS
    CCDS11903.1
    UniProtKB/Swiss-Prot
    Q8WVD3
    UniProtKB/TrEMBL
    A0A140VJT9
    Related
    ENSP00000261593.3, ENST00000261593.8
    Conserved Domains (2) summary
    pfam05605
    Location:156215
    zf-Di19; Drought induced 19 protein (Di19), zinc-binding
    cd16544
    Location:1459
    RING-HC_RNF138; RING finger, HC subclass, found in RING finger protein 138 (RNF138) and similar proteins
  3. NM_198128.2NP_937761.1  E3 ubiquitin-protein ligase RNF138 isoform 2

    See identical proteins and their annotated locations for NP_937761.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks two alternate in-frame exons compared to variant 1. The resulting protein (isoform 2) is shorter compared to isoform 1.
    Source sequence(s)
    AK023579, BC018107, DB091985
    Consensus CDS
    CCDS11904.1
    UniProtKB/Swiss-Prot
    Q8WVD3
    Related
    ENSP00000257190.5, ENST00000257190.9
    Conserved Domains (2) summary
    pfam05605
    Location:62121
    zf-Di19; Drought induced 19 protein (Di19), zinc-binding
    cl17238
    Location:1437
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p13 Primary Assembly

    Range
    32091858..32131561
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005258286.2XP_005258343.1  E3 ubiquitin-protein ligase RNF138 isoform X2

    See identical proteins and their annotated locations for XP_005258343.1

    UniProtKB/Swiss-Prot
    Q8WVD3
    Conserved Domains (2) summary
    pfam05605
    Location:62121
    zf-Di19; Drought induced 19 protein (Di19), zinc-binding
    cl17238
    Location:1437
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
  2. XM_005258285.1XP_005258342.1  E3 ubiquitin-protein ligase RNF138 isoform X1

    See identical proteins and their annotated locations for XP_005258342.1

    Conserved Domains (1) summary
    pfam05605
    Location:110169
    zf-Di19; Drought induced 19 protein (Di19), zinc-binding

RNA

  1. XR_935225.2 RNA Sequence

  2. XR_001753203.2 RNA Sequence

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