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VGLL1 vestigial like family member 1 [ Homo sapiens (human) ]

Gene ID: 51442, updated on 12-Oct-2019

Summary

Official Symbol
VGLL1provided by HGNC
Official Full Name
vestigial like family member 1provided by HGNC
Primary source
HGNC:HGNC:20985
See related
Ensembl:ENSG00000102243 MIM:300583
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TDU; VGL1
Summary
The protein encoded by this gene binds proteins of the TEA domain family of transcription factors (TEFs) through the Vg (vestigial) homology region found in its N-terminus. It may thus function as a specific coactivator for the mammalian TEFs. [provided by RefSeq, Sep 2009]
Expression
Restricted expression toward placenta (RPKM 103.1) See more
Orthologs

Genomic context

See VGLL1 in Genome Data Viewer
Location:
Xq26.3
Exon count:
5
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (136532215..136556799)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (135614311..135638966)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene bombesin receptor subtype 3 Neighboring gene HIV-1 Tat specific factor 1 Neighboring gene microRNA 934 Neighboring gene RNA, U6 small nuclear 320, pseudogene Neighboring gene long intergenic non-protein coding RNA 892

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
transcription coactivator activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
positive regulation of nucleic acid-templated transcription IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
transcription cofactor vestigial-like protein 1
Names
TONDU
WUGSC:H_GS188P18.1b
vestigial like 1
vgl-1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013270.2 RefSeqGene

    Range
    5064..29648
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_016267.4NP_057351.1  transcription cofactor vestigial-like protein 1

    See identical proteins and their annotated locations for NP_057351.1

    Status: REVIEWED

    Source sequence(s)
    BC000045
    Consensus CDS
    CCDS14658.1
    UniProtKB/Swiss-Prot
    Q99990
    Related
    ENSP00000359668.3, ENST00000370634.8
    Conserved Domains (1) summary
    pfam07545
    Location:2151
    Vg_Tdu; Vestigial/Tondu family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    136532215..136556799
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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