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UCHL1 ubiquitin C-terminal hydrolase L1 [ Bos taurus (domestic cattle) ]

Gene ID: 514394, updated on 18-Aug-2024

Summary

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Official Symbol
UCHL1provided by VGNC
Official Full Name
ubiquitin C-terminal hydrolase L1provided by VGNC
Primary source
VGNC:VGNC:36631
See related
BGD:BT12047; Ensembl:ENSBTAG00000005078
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 6
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 6 NC_037333.1 (60147577..60159280)

Chromosome 6 - NC_037333.1Genomic Context describing neighboring genes Neighboring gene large ribosomal subunit protein eL8-like Neighboring gene amyloid beta precursor protein binding family B member 2 Neighboring gene transfer RNA glutamic acid (anticodon UUC) Neighboring gene uncharacterized LOC132345503 Neighboring gene uncharacterized LOC132345504 Neighboring gene LIM and calponin homology domains 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037333.1 Chromosome 6 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Role of ubiquitin C-terminal hydrolase-L1 in antipolyspermy defense of mammalian oocytes. Susor A, et al. Biol Reprod, 2010 Jun. PMID 20164442
  2. 'Neuron-specific' protein gene product 9.5 (PGP 9.5) is also expressed in glioma cell lines and its expression depends on cellular growth state. Giambanco I, et al. FEBS Lett, 1991 Sep 23. PMID 1833240
  3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC133697

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein deubiquitination IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
ubiquitin carboxyl-terminal hydrolase isozyme L1
Names
PGP 9.5
PGP9.5
UCH-L1
neuron cytoplasmic protein 9.5
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
ubiquitin carboxyl-terminal hydrolase L1
ubiquitin thioesterase L1
NP_001039637.1
XP_005207929.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001046172.2 → NP_001039637.1  ubiquitin carboxyl-terminal hydrolase isozyme L1

    See identical proteins and their annotated locations for NP_001039637.1

    Status: PROVISIONAL

    Source sequence(s)
    BC111330
    UniProtKB/Swiss-Prot
    P23356, Q2NKZ2
    UniProtKB/TrEMBL
    A0AAF6ZGE9
    Related
    ENSBTAP00000044075.2, ENSBTAT00000046823.3
    Conserved Domains (1) summary
    cd09616
    Location:5 → 248
    Peptidase_C12_UCH_L1_L3; Cysteine peptidase C12 containing ubiquitin carboxyl-terminal hydrolase (UCH) families L1 and L3

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037333.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    60147577..60159280
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005207872.5 → XP_005207929.1  ubiquitin carboxyl-terminal hydrolase isozyme L1 isoform X1

    See identical proteins and their annotated locations for XP_005207929.1

    UniProtKB/TrEMBL
    A0AAF6ZGE9
    Related
    ENSBTAP00000063885.2, ENSBTAT00000066434.2
    Conserved Domains (1) summary
    cd09616
    Location:5 → 219
    Peptidase_C12_UCH_L1_L3; Cysteine peptidase C12 containing ubiquitin carboxyl-terminal hydrolase (UCH) families L1 and L3
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P23356.2 GenPept UniProtKB/Swiss-Prot:P23356

Gene LinkOut

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