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SCARA3 scavenger receptor class A member 3 [ Homo sapiens (human) ]

Gene ID: 51435, updated on 8-Dec-2022

Summary

Official Symbol
SCARA3provided by HGNC
Official Full Name
scavenger receptor class A member 3provided by HGNC
Primary source
HGNC:HGNC:19000
See related
Ensembl:ENSG00000168077 MIM:602728; AllianceGenome:HGNC:19000
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CSR; APC7; CSR1; MSLR1; MSRL1
Summary
This gene encodes a macrophage scavenger receptor-like protein. This protein has been shown to deplete reactive oxygen species, and thus play an important role in protecting cells from oxidative stress. The expression of this gene is induced by oxidative stress. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in endometrium (RPKM 16.5), brain (RPKM 14.0) and 23 other tissues See more
Orthologs
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Genomic context

See SCARA3 in Genome Data Viewer
Location:
8p21.1
Exon count:
11
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (27633463..27734141)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (27911259..27954152)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (27491419..27534288)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901919 Neighboring gene clusterin Neighboring gene microRNA 6843 Neighboring gene RNA, U6 small nuclear 1086, pseudogene Neighboring gene uncharacterized LOC124901921 Neighboring gene uncharacterized LOC124901920 Neighboring gene microRNA 3622b Neighboring gene microRNA 3622a Neighboring gene coiled-coil domain containing 25 Neighboring gene uncharacterized LOC107986934 Neighboring gene small nucleolar RNA U13 Neighboring gene RNA, U6 small nuclear 1276, pseudogene Neighboring gene establishment of sister chromatid cohesion N-acetyltransferase 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr Treatment of human primary astrocytes with HIV-1 Vpr downregulates expression of eleven genes, BNIP3, CYGB, DUOX2, DUSP1, FOXM1, GAPDH, HPRT1, MT3, MTL5, PTGS2, and SCARA3 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables scavenger receptor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in UV protection TAS
Traceable Author Statement
more info
PubMed 
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in response to oxidative stress TAS
Traceable Author Statement
more info
PubMed 
NOT involved_in toll-like receptor 3 signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
part_of collagen trimer IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
scavenger receptor class A member 3
Names
cellular stress response gene protein
cellular stress response protein
macrophage scavenger receptor-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016240.3NP_057324.2  scavenger receptor class A member 3 isoform 1

    See identical proteins and their annotated locations for NP_057324.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), also known as CSR1, encodes the longer isoform (1).
    Source sequence(s)
    AC013643
    Consensus CDS
    CCDS34871.1
    UniProtKB/Swiss-Prot
    Q6AZY7, Q9UM16
    Related
    ENSP00000301904.3, ENST00000301904.4
    Conserved Domains (1) summary
    pfam01391
    Location:469541
    Collagen; Collagen triple helix repeat (20 copies)
  2. NM_182826.2NP_878185.1  scavenger receptor class A member 3 isoform 2

    See identical proteins and their annotated locations for NP_878185.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), also known as CSR2, differs in the 3' end-region, which includes a part of the coding region, as compared to variant 1. The resulting isoform (2) has a distinct and shorter C-terminus, as compared to isoform 1.
    Source sequence(s)
    AB007830, AC013643
    Consensus CDS
    CCDS34870.1
    UniProtKB/Swiss-Prot
    Q6AZY7
    Related
    ENSP00000337985.3, ENST00000337221.8
    Conserved Domains (1) summary
    TIGR02168
    Location:128374
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    27633463..27734141
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047421850.1XP_047277806.1  scavenger receptor class A member 3 isoform X1

    UniProtKB/Swiss-Prot
    Q9UM16
  2. XM_017013535.2XP_016869024.1  scavenger receptor class A member 3 isoform X1

    UniProtKB/Swiss-Prot
    Q6AZY7, Q9UM16
    Conserved Domains (1) summary
    pfam01391
    Location:469541
    Collagen; Collagen triple helix repeat (20 copies)
  3. XM_017013536.3XP_016869025.1  scavenger receptor class A member 3 isoform X2

    Conserved Domains (1) summary
    TIGR02168
    Location:128374
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
  4. XM_017013537.2XP_016869026.1  scavenger receptor class A member 3 isoform X3

RNA

  1. XR_949419.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    27911259..27954152
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)