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ANAPC7 anaphase promoting complex subunit 7 [ Homo sapiens (human) ]

Gene ID: 51434, updated on 5-Jul-2020

Summary

Official Symbol
ANAPC7provided by HGNC
Official Full Name
anaphase promoting complex subunit 7provided by HGNC
Primary source
HGNC:HGNC:17380
See related
Ensembl:ENSG00000196510 MIM:606949
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
APC7
Summary
This gene encodes a tetratricopeptide repeat containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for proper protein ubiquitination function of APC/C and for the interaction of APC/C with certain transcription coactivators. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]
Expression
Ubiquitous expression in testis (RPKM 11.7), esophagus (RPKM 9.0) and 25 other tissues See more
Orthologs

Genomic context

See ANAPC7 in Genome Data Viewer
Location:
12q24.11
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (110372900..110403730, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (110810705..110841535, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 Neighboring gene RNA, 7SL, cytoplasmic 769, pseudogene Neighboring gene high mobility group AT-hook 1 pseudogene 3 Neighboring gene actin related protein 2/3 complex subunit 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
anaphase-promoting complex-dependent catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
anaphase-promoting complex-dependent catabolic process TAS
Traceable Author Statement
more info
 
cell division IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metaphase/anaphase transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of mitotic metaphase/anaphase transition IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein K11-linked ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of mitotic cell cycle phase transition TAS
Traceable Author Statement
more info
 
ubiquitin-dependent protein catabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
anaphase-promoting complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
anaphase-promoting complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
anaphase-promoting complex subunit 7
Names
cyclosome subunit 7

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001137664.1NP_001131136.1  anaphase-promoting complex subunit 7 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and 3' coding region (compared to variant 1), which results in a frameshift. It encodes isoform b which has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    BC040130, BG105587, DB003237
    Consensus CDS
    CCDS44971.1
    UniProtKB/Swiss-Prot
    Q9UJX3
    Related
    ENSP00000402314.2, ENST00000450008.2
    Conserved Domains (2) summary
    smart00028
    Location:373404
    TPR; Tetratricopeptide repeats
    sd00006
    Location:372402
    TPR; TPR repeat [structural motif]
  2. NM_016238.2NP_057322.2  anaphase-promoting complex subunit 7 isoform a

    See identical proteins and their annotated locations for NP_057322.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AL157481, BC098362, DB003237
    Consensus CDS
    CCDS9145.2
    UniProtKB/Swiss-Prot
    Q9UJX3
    UniProtKB/TrEMBL
    A0A024RBJ3, Q4KMX6, Q69YV3
    Related
    ENSP00000394394.3, ENST00000455511.7
    Conserved Domains (4) summary
    smart00028
    Location:373404
    TPR; Tetratricopeptide repeats
    sd00006
    Location:372402
    TPR; TPR repeat [structural motif]
    pfam13414
    Location:346404
    TPR_11; TPR repeat
    pfam13432
    Location:481542
    TPR_16; Tetratricopeptide repeat

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    110372900..110403730 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017019427.1XP_016874916.1  anaphase-promoting complex subunit 7 isoform X3

  2. XM_017019425.1XP_016874914.1  anaphase-promoting complex subunit 7 isoform X2

  3. XM_005253903.3XP_005253960.1  anaphase-promoting complex subunit 7 isoform X4

    Conserved Domains (4) summary
    smart00028
    Location:152183
    TPR; Tetratricopeptide repeats
    sd00006
    Location:151181
    TPR; TPR repeat [structural motif]
    pfam13414
    Location:125183
    TPR_11; TPR repeat
    pfam13432
    Location:260321
    TPR_16; Tetratricopeptide repeat
  4. XM_011538454.2XP_011536756.1  anaphase-promoting complex subunit 7 isoform X1

    Conserved Domains (4) summary
    smart00028
    Location:353384
    TPR; Tetratricopeptide repeats
    COG0457
    Location:241488
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:352382
    TPR; TPR repeat [structural motif]
    pfam13432
    Location:461522
    TPR_16; Tetratricopeptide repeat
  5. XM_017019428.1XP_016874917.1  anaphase-promoting complex subunit 7 isoform X4

    Conserved Domains (4) summary
    smart00028
    Location:152183
    TPR; Tetratricopeptide repeats
    sd00006
    Location:151181
    TPR; TPR repeat [structural motif]
    pfam13414
    Location:125183
    TPR_11; TPR repeat
    pfam13432
    Location:260321
    TPR_16; Tetratricopeptide repeat
  6. XM_017019426.1XP_016874915.1  anaphase-promoting complex subunit 7 isoform X3

RNA

  1. XR_001748748.1 RNA Sequence

  2. XR_001748747.1 RNA Sequence

  3. XR_001748749.1 RNA Sequence

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