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SUCO SUN domain containing ossification factor [ Homo sapiens (human) ]

Gene ID: 51430, updated on 13-Mar-2020

Summary

Official Symbol
SUCOprovided by HGNC
Official Full Name
SUN domain containing ossification factorprovided by HGNC
Primary source
HGNC:HGNC:1240
See related
Ensembl:ENSG00000094975
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CH1; OPT; SLP1; C1orf9
Expression
Ubiquitous expression in bone marrow (RPKM 30.3), testis (RPKM 17.2) and 25 other tissues See more
Orthologs

Genomic context

See SUCO in Genome Data Viewer
Location:
1q24.3
Exon count:
26
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (172532349..172611833)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (172501494..172580973)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102724528 Neighboring gene chromosome 1 open reading frame 105 Neighboring gene phosphatidylinositol glycan anchor biosynthesis class C Neighboring gene Sharpr-MPRA regulatory region 5023 Neighboring gene RNA, U6 small nuclear 693, pseudogene Neighboring gene Fas ligand

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
ossification IEA
Inferred from Electronic Annotation
more info
 
positive regulation of collagen biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of osteoblast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of bone remodeling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of bone remodeling ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
rough endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
rough endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
SUN domain-containing ossification factor
Names
SUN-like protein 1
membrane protein CH1
osteopotentia

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282750.2NP_001269679.1  SUN domain-containing ossification factor isoform 3 precursor

    See identical proteins and their annotated locations for NP_001269679.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' and 3' coding region, and initiates translation at a downstream AUG, compared to variant 2. The encoded protein (isoform 3) is shorter than isoform 2.
    Source sequence(s)
    AJ250075, AK302509, AL035291, DB093941
    Consensus CDS
    CCDS65727.1
    UniProtKB/Swiss-Prot
    Q9UBS9
    UniProtKB/TrEMBL
    B4DYM4
    Related
    ENSP00000476704.1, ENST00000610051.5
    Conserved Domains (2) summary
    pfam03938
    Location:565639
    OmpH; Outer membrane protein (OmpH-like)
    pfam07738
    Location:286415
    Sad1_UNC; Sad1 / UNC-like C-terminal
  2. NM_001282751.1NP_001269680.1  SUN domain-containing ossification factor isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains multiple differences in the 5' UTR and coding region, compared to variant 2. This variant represents translation initiation at a downstream AUG compared to variant 2; the 5'-most initiation codon, as used in variant 2, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream AUG.
    Source sequence(s)
    AJ250075, AL035291, BC144487, DB093941
    Consensus CDS
    CCDS72984.1
    UniProtKB/Swiss-Prot
    Q9UBS9
    UniProtKB/TrEMBL
    A0A087WV04
    Related
    ENSP00000479061.1, ENST00000616058.4
    Conserved Domains (1) summary
    pfam04899
    Location:373442
    MbeD_MobD; MbeD/MobD like
  3. NM_014283.5NP_055098.1  SUN domain-containing ossification factor isoform 1 precursor

    See identical proteins and their annotated locations for NP_055098.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR and 5' coding region and initiates translation at a downstream AUG, compared to variant 2. The encoded protein (isoform 1) is shorter than isoform 2.
    Source sequence(s)
    AJ250075, AL035291, BC137125, DB093941
    Consensus CDS
    CCDS1303.1
    UniProtKB/Swiss-Prot
    Q9UBS9
    Related
    ENSP00000263688.3, ENST00000263688.4
    Conserved Domains (3) summary
    pfam04899
    Location:9361005
    MbeD_MobD; MbeD/MobD like
    pfam03938
    Location:936991
    OmpH; Outer membrane protein (OmpH-like)
    pfam07738
    Location:323452
    Sad1_UNC; Sad1 / UNC-like C-terminal
  4. NM_016227.3NP_057311.3  SUN domain-containing ossification factor isoform 2

    See identical proteins and their annotated locations for NP_057311.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longest transcript and encodes the longest protein (isoform 1).
    Source sequence(s)
    AF097535, AJ250075, AL035291, Z94054
    Consensus CDS
    CCDS65726.1
    UniProtKB/Swiss-Prot
    Q9UBS9
    UniProtKB/TrEMBL
    A0A024R929
    Related
    ENSP00000356696.4, ENST00000367723.8
    Conserved Domains (2) summary
    pfam04899
    Location:10871156
    MbeD_MobD; MbeD/MobD like
    pfam07738
    Location:481603
    Sad1_UNC; Sad1 / UNC-like C-terminal

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    172532349..172611833
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006711376.1XP_006711439.1  SUN domain-containing ossification factor isoform X3

    Conserved Domains (3) summary
    pfam04899
    Location:892961
    MbeD_MobD; MbeD/MobD like
    pfam03938
    Location:892947
    OmpH; Outer membrane protein (OmpH-like)
    pfam07738
    Location:286408
    Sad1_UNC; Sad1 / UNC-like C-terminal
  2. XM_006711374.2XP_006711437.1  SUN domain-containing ossification factor isoform X1

    Conserved Domains (3) summary
    pfam04899
    Location:929998
    MbeD_MobD; MbeD/MobD like
    pfam03938
    Location:929984
    OmpH; Outer membrane protein (OmpH-like)
    pfam07738
    Location:323445
    Sad1_UNC; Sad1 / UNC-like C-terminal
  3. XM_006711375.2XP_006711438.1  SUN domain-containing ossification factor isoform X2

    Conserved Domains (2) summary
    pfam04899
    Location:899968
    MbeD_MobD; MbeD/MobD like
    pfam07738
    Location:286415
    Sad1_UNC; Sad1 / UNC-like C-terminal

RNA

  1. XR_921826.2 RNA Sequence

  2. XR_001737220.1 RNA Sequence

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