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PDE4C phosphodiesterase 4C [ Homo sapiens (human) ]

Gene ID: 5143, updated on 24-Nov-2020

Summary

Official Symbol
PDE4Cprovided by HGNC
Official Full Name
phosphodiesterase 4Cprovided by HGNC
Primary source
HGNC:HGNC:8782
See related
Ensembl:ENSG00000105650 MIM:600128
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DPDE1; PDE21
Summary
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]
Expression
Broad expression in placenta (RPKM 1.5), endometrium (RPKM 1.5) and 20 other tissues See more
Orthologs

Genomic context

See PDE4C in Genome Data Viewer
Location:
19p13.11
Exon count:
20
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (18207965..18248200, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (18318771..18359010, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene MPV17 mitochondrial inner membrane protein like 2 Neighboring gene RAB3A, member RAS oncogene family Neighboring gene uncharacterized LOC102725254 Neighboring gene uncharacterized LOC729966 Neighboring gene IQ motif containing N

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Cyclic AMP phosphodiesterase inhibitors AV411 and AV1013 inhibit HIV-1 replication and block HIV-1 Tat-induced neurotoxicity in human microglia, suggesting that cyclic AMP phosphodiesterase is involved in the Tat-mediated neurotoxicity PubMed
tat HIV-1 Tat decreases the intracellular levels of cAMP and CREB ser-133 phosphorylation through a signal transduction pathway involving sequential activation of phosphatidylinositol 3-kinase, AKT, and cyclic nucleoside phosphodiesterases PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC126222

Gene Ontology Provided by GOA

Function Evidence Code Pubs
3',5'-cyclic-AMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
3',5'-cyclic-nucleotide phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
cAMP catabolic process IEA
Inferred from Electronic Annotation
more info
 
signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cilium ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular space HDA PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
perinuclear region of cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
Names
dunce-like phosphodiesterase E1
phosphodiesterase 4C, cAMP-specific (phosphodiesterase E1 dunce homolog, Drosophila)
NP_000914.2
NP_001092288.1
NP_001092289.1
NP_001317101.1
NP_001356630.1
XP_011526358.1
XP_011526360.1
XP_024307303.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029629.1 RefSeqGene

    Range
    5001..45240
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000923.6NP_000914.2  cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 1

    See identical proteins and their annotated locations for NP_000914.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC068499, BC109067, DB313915, L20968, U66346, Z46632
    Consensus CDS
    CCDS12373.1
    UniProtKB/Swiss-Prot
    Q08493
    UniProtKB/TrEMBL
    O43849, Q32MM7
    Related
    ENSP00000469696.1, ENST00000594617.7
    Conserved Domains (1) summary
    pfam00233
    Location:387628
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  2. NM_001098818.4NP_001092288.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 3

    See identical proteins and their annotated locations for NP_001092288.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a shorter, distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC068499, BC109067, DB313915, L20968, U88713, Z46632
    Consensus CDS
    CCDS42523.1
    UniProtKB/Swiss-Prot
    Q08493
    UniProtKB/TrEMBL
    P78505, Q32MM7
    Related
    ENSP00000262805.10, ENST00000262805.16
    Conserved Domains (1) summary
    pfam00233
    Location:355596
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  3. NM_001098819.4NP_001092289.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 2

    See identical proteins and their annotated locations for NP_001092289.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC068499, BC109067, DB313915, L20968, U88712, Z46632
    Consensus CDS
    CCDS46016.1
    UniProtKB/Swiss-Prot
    Q08493
    UniProtKB/TrEMBL
    Q32MM7, Q7KYS4
    Related
    ENSP00000402091.1, ENST00000447275.7
    Conserved Domains (1) summary
    pfam00233
    Location:281522
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  4. NM_001330172.2NP_001317101.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC005759, AC008397, AC068499
    Consensus CDS
    CCDS12373.1
    UniProtKB/Swiss-Prot
    Q08493
  5. NM_001369701.2NP_001356630.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC005759, AC068499
    Conserved Domains (1) summary
    pfam00233
    Location:156397
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    18207965..18248200 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528056.3XP_011526358.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform X1

    See identical proteins and their annotated locations for XP_011526358.1

    UniProtKB/Swiss-Prot
    Q08493
    Conserved Domains (1) summary
    pfam00233
    Location:281522
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  2. XM_024451535.1XP_024307303.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform X2

    Related
    ENSP00000439470.1, ENST00000539010.5
    Conserved Domains (1) summary
    pfam00233
    Location:156397
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  3. XM_011528058.3XP_011526360.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform X2

    See identical proteins and their annotated locations for XP_011526360.1

    UniProtKB/TrEMBL
    Q32MM7
    Conserved Domains (1) summary
    pfam00233
    Location:156397
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_040546.1: Suppressed sequence

    Description
    NR_040546.1: This RefSeq was removed because currently there is insufficient support for the transcript.
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