Format

Send to:

Choose Destination

SNX9 sorting nexin 9 [ Homo sapiens (human) ]

Gene ID: 51429, updated on 20-Jan-2019

Summary

Official Symbol
SNX9provided by HGNC
Official Full Name
sorting nexin 9provided by HGNC
Primary source
HGNC:HGNC:14973
See related
Ensembl:ENSG00000130340 MIM:605952
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SDP1; WISP; SH3PX1; SH3PXD3A
Summary
This gene encodes a member of the sorting nexin family. Members of this family contain a phosphoinositide binding domain, and are involved in intracellular trafficking. The encoded protein does not contain a coiled coil region, like some family members, but does contain a SRC homology domain near its N-terminus. The encoded protein is reported to have a variety of interaction partners, including of adaptor protein 2 , dynamin, tyrosine kinase non-receptor 2, Wiskott-Aldrich syndrome-like, and ARP3 actin-related protein 3. The encoded protein is implicated in several stages of intracellular trafficking, including endocytosis, macropinocytosis, and F-actin nucleation. [provided by RefSeq, Jul 2013]
Expression
Ubiquitous expression in gall bladder (RPKM 27.0), esophagus (RPKM 26.7) and 25 other tissues See more
Orthologs

Genomic context

See SNX9 in Genome Data Viewer
Location:
6q25.3
Exon count:
22
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 6 NC_000006.12 (157716046..157945077)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (158137078..158366109)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene zinc finger DHHC-type containing 14 Neighboring gene uncharacterized LOC105378077 Neighboring gene uncharacterized LOC107986663 Neighboring gene uncharacterized LOC105378078 Neighboring gene RNA, U6 small nuclear 786, pseudogene Neighboring gene heat shock protein family E (Hsp10) member 1 pseudogene 26 Neighboring gene SYNJ2 intronic transcript 1 Neighboring gene synaptojanin 2 Neighboring gene serine active site containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Clathrin derived vesicle budding, organism-specific biosystem (from REACTOME)
    Clathrin derived vesicle budding, organism-specific biosystemThere at least two classes of clathrin coated vesicles in cells, one predominantly Golgi-associated, involved in budding from the trans-Golgi network and the other at the plasma membrane. Here the cl...
  • Clathrin-mediated endocytosis, organism-specific biosystem (from REACTOME)
    Clathrin-mediated endocytosis, organism-specific biosystemClathrin-mediated endocytosis (CME) is one of a number of process that control the uptake of material from the plasma membrane, and leads to the formation of clathrin-coated vesicles (Pearse et al, 1...
  • Golgi Associated Vesicle Biogenesis, organism-specific biosystem (from REACTOME)
    Golgi Associated Vesicle Biogenesis, organism-specific biosystemProteins that have been synthesized, processed and sorted eventually reach the final steps of the secretory pathway. This pathway is responsible not only for proteins that are secreted from the cell ...
  • Membrane Trafficking, organism-specific biosystem (from REACTOME)
    Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
  • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
    Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...
  • trans-Golgi Network Vesicle Budding, organism-specific biosystem (from REACTOME)
    trans-Golgi Network Vesicle Budding, organism-specific biosystemAfter passing through the Golgi complex, secretory cargo is packaged into post-Golgi transport intermediates (post-Golgi), which translocate plus-end directed along microtubules to the plasma membran...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
1-phosphatidylinositol binding IDA
Inferred from Direct Assay
more info
PubMed 
Arp2/3 complex binding IDA
Inferred from Direct Assay
more info
PubMed 
cadherin binding HDA PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
phosphatidylinositol binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cleavage furrow formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
endosomal transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
intracellular protein transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
lipid tube assembly IDA
Inferred from Direct Assay
more info
PubMed 
membrane organization TAS
Traceable Author Statement
more info
 
mitotic cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
plasma membrane tubulation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of membrane protein ectodomain proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein oligomerization IDA
Inferred from Direct Assay
more info
PubMed 
receptor-mediated endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with clathrin-coated vesicle IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic vesicle membrane IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
extrinsic component of cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
ruffle IEA
Inferred from Electronic Annotation
more info
 
trans-Golgi network IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
sorting nexin-9
Names
SH3 and PX domain-containing protein 1
SH3 and PX domain-containing protein 3A
Wiskott-Aldrich syndrome protein (WASP) interactor protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016224.4NP_057308.1  sorting nexin-9

    See identical proteins and their annotated locations for NP_057308.1

    Status: REVIEWED

    Source sequence(s)
    AF121859, AL139330, DA315945, DA336311
    Consensus CDS
    CCDS5253.1
    UniProtKB/Swiss-Prot
    Q9Y5X1
    Related
    ENSP00000376024.3, ENST00000392185.7
    Conserved Domains (3) summary
    cd07285
    Location:250375
    PX_SNX9; The phosphoinositide binding Phox Homology domain of Sorting Nexin 9
    cd07668
    Location:386595
    BAR_SNX9; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 9
    cd11898
    Location:460
    SH3_SNX9; Src Homology 3 domain of Sorting nexin 9

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p12 Primary Assembly

    Range
    157716046..157945077
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005267015.2XP_005267072.1  sorting nexin-9 isoform X1

    Conserved Domains (3) summary
    cd07285
    Location:243368
    PX_SNX9; The phosphoinositide binding Phox Homology domain of Sorting Nexin 9
    cd07668
    Location:379588
    BAR_SNX9; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 9
    cd11898
    Location:153
    SH3_SNX9; Src Homology 3 domain of Sorting nexin 9
  2. XM_011535886.3XP_011534188.1  sorting nexin-9 isoform X2

    Conserved Domains (2) summary
    cd07285
    Location:156281
    PX_SNX9; The phosphoinositide binding Phox Homology domain of Sorting Nexin 9
    cd07668
    Location:292501
    BAR_SNX9; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 9
Support Center