Format

Send to:

Choose Destination

POLK DNA polymerase kappa [ Homo sapiens (human) ]

Gene ID: 51426, updated on 9-Feb-2020

Summary

Official Symbol
POLKprovided by HGNC
Official Full Name
DNA polymerase kappaprovided by HGNC
Primary source
HGNC:HGNC:9183
See related
Ensembl:ENSG00000122008 MIM:605650
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DINP; POLQ; DINB1
Summary
This gene encodes a member of the DNA polymerase type-Y family of proteins. The encoded protein is a specialized DNA polymerase that catalyzes translesion DNA synthesis, which allows DNA replication in the presence of DNA lesions. Human cell lines lacking a functional copy of this gene exhibit impaired genome integrity and enhanced susceptibility to oxidative damage. Mutations in this gene that impair enzyme activity may be associated with prostate cancer in human patients. [provided by RefSeq, Sep 2016]
Expression
Ubiquitous expression in thyroid (RPKM 6.4), testis (RPKM 4.9) and 25 other tissues See more
Orthologs

Genomic context

See POLK in Genome Data Viewer
Location:
5q13.3
Exon count:
21
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (75511308..75605820)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (74807657..74895646)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene 3-hydroxy-3-methylglutaryl-CoA reductase Neighboring gene ribosomal protein S26 pseudogene 26 Neighboring gene ceramide transporter 1 Neighboring gene RNA, U7 small nuclear 175 pseudogene Neighboring gene ankyrin repeat and death domain containing 1B Neighboring gene uncharacterized LOC107986424 Neighboring gene POC5 centriolar protein Neighboring gene RNA, U6 small nuclear 680, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-directed DNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
damaged DNA binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
DNA repair IDA
Inferred from Direct Assay
more info
PubMed 
DNA repair TAS
Traceable Author Statement
more info
PubMed 
DNA replication IEA
Inferred from Electronic Annotation
more info
 
cellular response to DNA damage stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to UV IDA
Inferred from Direct Assay
more info
PubMed 
error-prone translesion synthesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
error-prone translesion synthesis IDA
Inferred from Direct Assay
more info
PubMed 
error-prone translesion synthesis TAS
Traceable Author Statement
more info
 
nucleotide-excision repair, DNA gap filling IMP
Inferred from Mutant Phenotype
more info
PubMed 
nucleotide-excision repair, DNA gap filling TAS
Traceable Author Statement
more info
 
nucleotide-excision repair, DNA incision TAS
Traceable Author Statement
more info
 
nucleotide-excision repair, DNA incision, 5'-to lesion TAS
Traceable Author Statement
more info
 
transcription-coupled nucleotide-excision repair TAS
Traceable Author Statement
more info
 
translesion synthesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
translesion synthesis TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
nuclear body IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with site of DNA damage IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
DNA polymerase kappa
Names
polymerase (DNA directed) kappa
NP_001332850.1
NP_001332851.1
NP_057302.1
XP_005248591.1
XP_006714715.1
XP_011541765.1
XP_011541766.1
XP_011541769.1
XP_016865048.1
XP_016865049.1
XP_016865050.1
XP_016865052.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051590.1 RefSeqGene

    Range
    5001..99071
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001345921.1NP_001332850.1  DNA polymerase kappa isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start site compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AC010245, AC026424, AC116341
  2. NM_001345922.1NP_001332851.1  DNA polymerase kappa isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and initiates translation at a downstream start site compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AC010245, AC026424, AC116341
    UniProtKB/Swiss-Prot
    Q9UBT6
  3. NM_016218.3NP_057302.1  DNA polymerase kappa isoform 1

    See identical proteins and their annotated locations for NP_057302.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC010245, AC116341, AF163570
    Consensus CDS
    CCDS4030.1
    UniProtKB/Swiss-Prot
    Q9UBT6
    UniProtKB/TrEMBL
    A0A024RAP4
    Related
    ENSP00000241436.4, ENST00000241436.8
    Conserved Domains (3) summary
    smart00734
    Location:621647
    ZnF_Rad18; Rad18-like CCHC zinc finger
    cd03586
    Location:104516
    PolY_Pol_IV_kappa; DNA Polymerase IV/Kappa
    PRK02406
    Location:108522
    PRK02406; DNA polymerase IV; Validated

RNA

  1. NR_144315.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC010245, AC026424, AC116341

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    75511308..75605820
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005248534.5XP_005248591.1  DNA polymerase kappa isoform X1

    See identical proteins and their annotated locations for XP_005248591.1

    Conserved Domains (3) summary
    smart00734
    Location:635661
    ZnF_Rad18; Rad18-like CCHC zinc finger
    cd03586
    Location:104530
    PolY_Pol_IV_kappa; DNA Polymerase IV/Kappa
    PRK02406
    Location:108536
    PRK02406; DNA polymerase IV; Validated
  2. XM_017009561.2XP_016865050.1  DNA polymerase kappa isoform X3

  3. XM_011543463.3XP_011541765.1  DNA polymerase kappa isoform X1

    See identical proteins and their annotated locations for XP_011541765.1

    Conserved Domains (3) summary
    smart00734
    Location:635661
    ZnF_Rad18; Rad18-like CCHC zinc finger
    cd03586
    Location:104530
    PolY_Pol_IV_kappa; DNA Polymerase IV/Kappa
    PRK02406
    Location:108536
    PRK02406; DNA polymerase IV; Validated
  4. XM_011543464.3XP_011541766.1  DNA polymerase kappa isoform X1

    See identical proteins and their annotated locations for XP_011541766.1

    Conserved Domains (3) summary
    smart00734
    Location:635661
    ZnF_Rad18; Rad18-like CCHC zinc finger
    cd03586
    Location:104530
    PolY_Pol_IV_kappa; DNA Polymerase IV/Kappa
    PRK02406
    Location:108536
    PRK02406; DNA polymerase IV; Validated
  5. XM_011543467.3XP_011541769.1  DNA polymerase kappa isoform X4

    Conserved Domains (3) summary
    smart00734
    Location:545571
    ZnF_Rad18; Rad18-like CCHC zinc finger
    cd03586
    Location:14440
    PolY_Pol_IV_kappa; DNA Polymerase IV/Kappa
    PRK02406
    Location:18446
    PRK02406; DNA polymerase IV; Validated
  6. XM_017009563.2XP_016865052.1  DNA polymerase kappa isoform X5

    UniProtKB/Swiss-Prot
    Q9UBT6
    Conserved Domains (3) summary
    smart00734
    Location:531557
    ZnF_Rad18; Rad18-like CCHC zinc finger
    cd03586
    Location:14426
    PolY_Pol_IV_kappa; DNA Polymerase IV/Kappa
    PRK02406
    Location:18432
    PRK02406; DNA polymerase IV; Validated
  7. XM_017009559.2XP_016865048.1  DNA polymerase kappa isoform X2

    UniProtKB/Swiss-Prot
    Q9UBT6
    UniProtKB/TrEMBL
    A0A024RAP4
    Conserved Domains (3) summary
    smart00734
    Location:621647
    ZnF_Rad18; Rad18-like CCHC zinc finger
    cd03586
    Location:104516
    PolY_Pol_IV_kappa; DNA Polymerase IV/Kappa
    PRK02406
    Location:108522
    PRK02406; DNA polymerase IV; Validated
  8. XM_017009560.2XP_016865049.1  DNA polymerase kappa isoform X2

    UniProtKB/Swiss-Prot
    Q9UBT6
    UniProtKB/TrEMBL
    A0A024RAP4
    Conserved Domains (3) summary
    smart00734
    Location:621647
    ZnF_Rad18; Rad18-like CCHC zinc finger
    cd03586
    Location:104516
    PolY_Pol_IV_kappa; DNA Polymerase IV/Kappa
    PRK02406
    Location:108522
    PRK02406; DNA polymerase IV; Validated
  9. XM_006714652.4XP_006714715.1  DNA polymerase kappa isoform X6

    Conserved Domains (2) summary
    smart00734
    Location:206232
    ZnF_Rad18; Rad18-like CCHC zinc finger
    cl12025
    Location:1101
    PolY; Y-family of DNA polymerases

RNA

  1. XR_001742107.2 RNA Sequence

  2. XR_001742105.2 RNA Sequence

  3. XR_241784.3 RNA Sequence

  4. XR_002956163.1 RNA Sequence

  5. XR_948273.3 RNA Sequence

    Related
    ENST00000514141.5
  6. XR_001742108.2 RNA Sequence

Support Center