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POLK DNA polymerase kappa [ Homo sapiens (human) ]

Gene ID: 51426, updated on 29-Aug-2021

Summary

Official Symbol
POLKprovided by HGNC
Official Full Name
DNA polymerase kappaprovided by HGNC
Primary source
HGNC:HGNC:9183
See related
Ensembl:ENSG00000122008 MIM:605650
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DINP; POLQ; DINB1
Summary
This gene encodes a member of the DNA polymerase type-Y family of proteins. The encoded protein is a specialized DNA polymerase that catalyzes translesion DNA synthesis, which allows DNA replication in the presence of DNA lesions. Human cell lines lacking a functional copy of this gene exhibit impaired genome integrity and enhanced susceptibility to oxidative damage. Mutations in this gene that impair enzyme activity may be associated with prostate cancer in human patients. [provided by RefSeq, Sep 2016]
Annotation information
Annotation category: partial on reference assembly
Expression
Ubiquitous expression in thyroid (RPKM 6.4), testis (RPKM 4.9) and 25 other tissues See more
Orthologs
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Genomic context

See POLK in Genome Data Viewer
Location:
5q13.3
Exon count:
18
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (75511891..75601144)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (74807575..74901645)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene 3-hydroxy-3-methylglutaryl-CoA reductase Neighboring gene ribosomal protein S26 pseudogene 26 Neighboring gene ceramide transporter 1 Neighboring gene RNA, U7 small nuclear 175 pseudogene Neighboring gene ankyrin repeat and death domain containing 1B Neighboring gene uncharacterized LOC107986424 Neighboring gene POC5 centriolar protein Neighboring gene RNA, U6 small nuclear 680, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-directed DNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables damaged DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in DNA repair IDA
Inferred from Direct Assay
more info
PubMed 
involved_in DNA repair TAS
Traceable Author Statement
more info
PubMed 
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to DNA damage stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to UV IDA
Inferred from Direct Assay
more info
PubMed 
involved_in error-prone translesion synthesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in error-prone translesion synthesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in nucleotide-excision repair, DNA gap filling IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in nuclear body IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with site of DNA damage IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
DNA polymerase kappa
Names
polymerase (DNA directed) kappa
NP_001332850.1
NP_001332851.1
NP_001374039.1
NP_001374040.1
NP_001374042.1
NP_057302.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051590.1 RefSeqGene

    Range
    5001..99071
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001345921.3NP_001332850.1  DNA polymerase kappa isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC010245, AC026424, AC116341
  2. NM_001345922.3NP_001332851.1  DNA polymerase kappa isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC010245, AC026424, AC116341
    UniProtKB/Swiss-Prot
    Q9UBT6
  3. NM_001387110.3NP_001374039.1  DNA polymerase kappa isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC010245, AC026424, AC116341
    Conserved Domains (3) summary
    smart00734
    Location:618644
    ZnF_Rad18; Rad18-like CCHC zinc finger
    cd03586
    Location:104513
    PolY_Pol_IV_kappa; DNA Polymerase IV/Kappa
    cl02765
    Location:773799
    zf-WRNIP1_ubi; Werner helicase-interacting protein 1 ubiquitin-binding domain
  4. NM_001387111.3NP_001374040.1  DNA polymerase kappa isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC010245, AC026424, AC116341
    Conserved Domains (3) summary
    smart00734
    Location:635661
    ZnF_Rad18; Rad18-like CCHC zinc finger
    cd03586
    Location:104530
    PolY_Pol_IV_kappa; DNA Polymerase IV/Kappa
    cl02765
    Location:790816
    zf-WRNIP1_ubi; Werner helicase-interacting protein 1 ubiquitin-binding domain
  5. NM_001387113.3NP_001374042.1  DNA polymerase kappa isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC010245, AC026424, AC116341
    Conserved Domains (3) summary
    smart00734
    Location:621647
    ZnF_Rad18; Rad18-like CCHC zinc finger
    cd03586
    Location:104516
    PolY_Pol_IV_kappa; DNA Polymerase IV/Kappa
    cl02765
    Location:776802
    zf-WRNIP1_ubi; Werner helicase-interacting protein 1 ubiquitin-binding domain
  6. NM_001395893.1NP_001382822.1  DNA polymerase kappa isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC010245, AC026424, AC116341
  7. NM_001395894.1NP_001382823.1  DNA polymerase kappa isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC010245, AC026424, AC116341
  8. NM_001395897.1NP_001382826.1  DNA polymerase kappa isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC010245, AC026424, AC116341
  9. NM_001395899.1NP_001382828.1  DNA polymerase kappa isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC010245, AC026424, AC116341
  10. NM_001395900.1NP_001382829.1  DNA polymerase kappa isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC010245, AC026424, AC116341
  11. NM_001395901.1NP_001382830.1  DNA polymerase kappa isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC010245, AC026424, AC116341
  12. NM_001395902.1NP_001382831.1  DNA polymerase kappa isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC010245, AC026424, AC116341
  13. NM_016218.6NP_057302.1  DNA polymerase kappa isoform 1

    See identical proteins and their annotated locations for NP_057302.1

    Status: REVIEWED

    Source sequence(s)
    AC010245, AC026424, AC116341
    Consensus CDS
    CCDS4030.1
    UniProtKB/Swiss-Prot
    Q9UBT6
    UniProtKB/TrEMBL
    A0A024RAP4
    Related
    ENSP00000241436.4, ENST00000241436.8
    Conserved Domains (3) summary
    smart00734
    Location:621647
    ZnF_Rad18; Rad18-like CCHC zinc finger
    cd03586
    Location:104516
    PolY_Pol_IV_kappa; DNA Polymerase IV/Kappa
    cl02765
    Location:776802
    zf-WRNIP1_ubi; Werner helicase-interacting protein 1 ubiquitin-binding domain

RNA

  1. NR_144315.3 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC010245, AC026424, AC116341
  2. NR_170559.3 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC010245, AC026424, AC116341
  3. NR_170560.3 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC010245, AC026424, AC116341
    Related
    ENST00000514141.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    75511891..75601144
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001387112.1: Suppressed sequence

    Description
    NM_001387112.1: This RefSeq was removed because currently there is support for the transcript but not for the protein.
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