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PRKAG2 protein kinase AMP-activated non-catalytic subunit gamma 2 [ Homo sapiens (human) ]

Gene ID: 51422, updated on 5-May-2020

Summary

Official Symbol
PRKAG2provided by HGNC
Official Full Name
protein kinase AMP-activated non-catalytic subunit gamma 2provided by HGNC
Primary source
HGNC:HGNC:9386
See related
Ensembl:ENSG00000106617 MIM:602743
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AAKG; CMH6; WPWS; AAKG2; H91620p
Summary
AMP-activated protein kinase (AMPK) is a heterotrimeric protein composed of a catalytic alpha subunit, a noncatalytic beta subunit, and a noncatalytic regulatory gamma subunit. Various forms of each of these subunits exist, encoded by different genes. AMPK is an important energy-sensing enzyme that monitors cellular energy status and functions by inactivating key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This gene is a member of the AMPK gamma subunit family. Mutations in this gene have been associated with Wolff-Parkinson-White syndrome, familial hypertrophic cardiomyopathy, and glycogen storage disease of the heart. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jan 2015]
Expression
Ubiquitous expression in heart (RPKM 15.2), prostate (RPKM 4.8) and 24 other tissues See more
Orthologs

Genomic context

See PRKAG2 in Genome Data Viewer
Location:
7q36.1
Exon count:
22
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (151556114..151877115, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (151253200..151574316, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 76, pseudogene Neighboring gene Ras homolog, mTORC1 binding Neighboring gene eukaryotic translation termination factor 1 pseudogene 2 Neighboring gene Sharpr-MPRA regulatory region 3106 Neighboring gene VISTA enhancer hs2193 Neighboring gene VISTA enhancer hs2194 Neighboring gene VISTA enhancer hs2199 Neighboring gene VISTA enhancer hs2200 Neighboring gene uncharacterized LOC644090 Neighboring gene PRKAG2 antisense RNA 1 Neighboring gene RNA, U6 small nuclear 604, pseudogene Neighboring gene uncharacterized LOC105375570

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Professional guidelines

Description
Professional guideline
ACMG 2013

The ACMG recommends that laboratories performing clinical sequencing seek and report mutations in PRKAG2 that are pathogenic or expected to be pathogenic.

GuidelinePubMed

Associated conditions

Description Tests
Familial hypertrophic cardiomyopathy 6
MedGen: C1833236 OMIM: 600858
Compare labs
Glycogen storage disease of heart, lethal congenital
MedGen: C1849813 OMIM: 261740 GeneReviews: Not available
Compare labs
Wolff-Parkinson-White pattern
MedGen: C0043202 OMIM: 194200 GeneReviews: Not available
Compare labs

Copy number response

Description
Copy number response
Haploinsufficency

No evidence available (Last evaluated (2015-11-05)

ClinGen Genome Curation Page
Triplosensitivity

No evidence available (Last evaluated (2015-11-05)

ClinGen Genome Curation Page

NHGRI GWAS Catalog

Description
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.
NHGRI GWA Catalog
Genome-wide association analysis of age at onset and psychotic symptoms in bipolar disorder.
NHGRI GWA Catalog
Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium.
NHGRI GWA Catalog
New loci associated with kidney function and chronic kidney disease.
NHGRI GWA Catalog
Seventy-five genetic loci influencing the human red blood cell.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Knockdown of SIRT1 by its inhibitor or siRNA results in Tat-mediated reduction of phosphorylation of AMP-activated protein kinase (AMPK) and downstream acetyl-CoA carboxylase (ACC) PubMed
tat HIV-1 Tat induces IL-6 and TNF-alpha expression through the activation of cAMP-dependent protein kinase pathways PubMed
Vpr vpr HIV-1 Vpr directly interacts with PKA and is phosphorylated at position Ser79 by PKA. PKA activity is necessary for virion-delivered Vpr cell cycle arrest PubMed
matrix gag HIV-1 Matrix impairs proliferation of normal lymphocytes in vitro by inducing the activity of the inhibitory protein kinase A (PKA) PubMed
gag Protein kinase A (PKA) has been shown to phosphorylate HIV-1 Matrix in vitro PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ADP binding IDA
Inferred from Direct Assay
more info
PubMed 
AMP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
AMP binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to AMP-activated protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
AMP-activated protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
cAMP-dependent protein kinase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
cAMP-dependent protein kinase regulator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
phosphorylase kinase regulator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein kinase activator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein kinase binding IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
ATP biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
activation of protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
carnitine shuttle TAS
Traceable Author Statement
more info
 
cell cycle arrest TAS
Traceable Author Statement
more info
 
cellular response to glucose starvation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
glycogen metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
intracellular signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
macroautophagy TAS
Traceable Author Statement
more info
 
negative regulation of cAMP-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of peptidyl-threonine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of catalytic activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of fatty acid biosynthetic process TAS
Traceable Author Statement
more info
 
regulation of fatty acid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of fatty acid oxidation TAS
Traceable Author Statement
more info
PubMed 
regulation of glucose import TAS
Traceable Author Statement
more info
PubMed 
regulation of glycolytic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of macroautophagy TAS
Traceable Author Statement
more info
 
regulation of signal transduction by p53 class mediator TAS
Traceable Author Statement
more info
 
sterol biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular space HDA PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleotide-activated protein kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleotide-activated protein kinase complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
5'-AMP-activated protein kinase subunit gamma-2
Names
AMPK subunit gamma-2
epididymis secretory sperm binding protein
protein kinase, AMP-activated, gamma 2 non-catalytic subunit

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007486.1 RefSeqGene

    Range
    5117..326104
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001040633.1NP_001035723.1  5'-AMP-activated protein kinase subunit gamma-2 isoform c

    See identical proteins and their annotated locations for NP_001035723.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (c) contains an alternate 5' exon and the translation starts from a downstream AUG codon, compared to variant a. The resulting isoform (c) has a shorter N-terminus when compared to isoform a.
    Source sequence(s)
    BC020540, BC068598, BM988346, DA084454, DA187928, DA697901
    Consensus CDS
    CCDS43683.1
    UniProtKB/Swiss-Prot
    Q9UGJ0
    Related
    ENSP00000376549.2, ENST00000392801.6
    Conserved Domains (3) summary
    cd04618
    Location:234363
    CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
    cd04641
    Location:390509
    CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
    cl28033
    Location:2177
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
  2. NM_001304527.1NP_001291456.1  5'-AMP-activated protein kinase subunit gamma-2 isoform d

    See identical proteins and their annotated locations for NP_001291456.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (d) lacks part of the 5' coding region, contains an alternate 5'-terminal exon, and uses an alternate start codon, compared to variant a. The encoded isoform (d) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AK301123, BC020540, BM988346, DC379218
    UniProtKB/Swiss-Prot
    Q9UGJ0
    UniProtKB/TrEMBL
    B7Z6X8
    Related
    ENSP00000419577.2, ENST00000492843.6
    Conserved Domains (2) summary
    cd04618
    Location:153282
    CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
    cd04641
    Location:309428
    CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
  3. NM_001304531.1NP_001291460.1  5'-AMP-activated protein kinase subunit gamma-2 isoform b

    See identical proteins and their annotated locations for NP_001291460.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (e) lacks part of the 5' coding region, contains an alternate 5'-terminal exon, and uses a downstream in-frame start codon, compared to variant a. The encoded isoform (b) has a shorter N-terminus compared to isoform a. Variants b and e encode the same isoform (b).
    Source sequence(s)
    AW664063, BC020540, BM988346, DA151645
    Consensus CDS
    CCDS47752.1
    UniProtKB/Swiss-Prot
    Q9UGJ0
    Related
    ENSP00000419493.2, ENST00000476632.2
    Conserved Domains (2) summary
    cd04618
    Location:37166
    CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
    cd04641
    Location:193312
    CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
  4. NM_001363698.1NP_001350627.1  5'-AMP-activated protein kinase subunit gamma-2 isoform e

    Status: REVIEWED

    Source sequence(s)
    AC006358, AC006966
    Consensus CDS
    CCDS87567.1
    Conserved Domains (2) summary
    cd04618
    Location:154283
    CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
    cd04641
    Location:310429
    CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
  5. NM_016203.4NP_057287.2  5'-AMP-activated protein kinase subunit gamma-2 isoform a

    See identical proteins and their annotated locations for NP_057287.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (a) represents the longest transcript and encodes the longest isoform (a, also referred to as PRKAG2-a).
    Source sequence(s)
    AJ249976, BC020540, DA123009
    Consensus CDS
    CCDS5928.1
    UniProtKB/Swiss-Prot
    Q9UGJ0
    UniProtKB/TrEMBL
    A0A090N8Q6
    Related
    ENSP00000287878.3, ENST00000287878.9
    Conserved Domains (3) summary
    cd04618
    Location:278407
    CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
    cd04641
    Location:434553
    CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
    cl28033
    Location:46221
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
  6. NM_024429.1NP_077747.1  5'-AMP-activated protein kinase subunit gamma-2 isoform b

    See identical proteins and their annotated locations for NP_077747.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (b) contains a distinct 5' UTR and lacks a large in-frame portion of the 5' coding region, compared to variant a. The resulting isoform (b, also referred to as PRKAG2-b) has a much shorter N-terminus when compared to isoform a. Variants b and e encode the same isoform (b).
    Source sequence(s)
    AK001887, BC020540, BM988346
    Consensus CDS
    CCDS47752.1
    UniProtKB/Swiss-Prot
    Q9UGJ0
    Related
    ENSP00000387386.2, ENST00000418337.6
    Conserved Domains (2) summary
    cd04618
    Location:37166
    CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
    cd04641
    Location:193312
    CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    151556114..151877115 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017012269.1XP_016867758.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X8

    Conserved Domains (3) summary
    cd04618
    Location:277406
    CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
    cd04641
    Location:433552
    CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
    cl28033
    Location:46221
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
  2. XM_005250002.4XP_005250059.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X3

    Conserved Domains (3) summary
    COG0517
    Location:359479
    CBS; CBS domain [Signal transduction mechanisms]
    cd04618
    Location:278407
    CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
    cd04641
    Location:434553
    CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
  3. XM_017012278.1XP_016867767.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X20

    Conserved Domains (2) summary
    cd04618
    Location:8145
    CBS_euAMPK_gamma-like_repeat1; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in AMP-activated protein kinase gamma-like proteins, repeat 1
    cd04641
    Location:171294
    CBS_euAMPK_gamma-like_repeat2; CBS pair domain found in 5'-AMP (adenosine monophosphate)-activated protein kinase
  4. XM_011516287.1XP_011514589.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X16

    Conserved Domains (3) summary
    COG0517
    Location:98218
    CBS; CBS domain [Signal transduction mechanisms]
    cd04618
    Location:17146
    CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
    cd04641
    Location:173292
    CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
  5. XM_017012280.2XP_016867769.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X20

    Conserved Domains (2) summary
    cd04618
    Location:8145
    CBS_euAMPK_gamma-like_repeat1; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in AMP-activated protein kinase gamma-like proteins, repeat 1
    cd04641
    Location:171294
    CBS_euAMPK_gamma-like_repeat2; CBS pair domain found in 5'-AMP (adenosine monophosphate)-activated protein kinase
  6. XM_017012275.2XP_016867764.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X16

    Conserved Domains (3) summary
    COG0517
    Location:98218
    CBS; CBS domain [Signal transduction mechanisms]
    cd04618
    Location:17146
    CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
    cd04641
    Location:173292
    CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
  7. XM_017012279.2XP_016867768.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X20

    Related
    ENSP00000498384.1, ENST00000650858.1
    Conserved Domains (2) summary
    cd04618
    Location:8145
    CBS_euAMPK_gamma-like_repeat1; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in AMP-activated protein kinase gamma-like proteins, repeat 1
    cd04641
    Location:171294
    CBS_euAMPK_gamma-like_repeat2; CBS pair domain found in 5'-AMP (adenosine monophosphate)-activated protein kinase
  8. XM_017012271.2XP_016867760.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X10

    Related
    ENSP00000499111.1, ENST00000652047.1
  9. XM_017012268.2XP_016867757.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X7

  10. XM_005250004.4XP_005250061.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X6

    Conserved Domains (3) summary
    cd04618
    Location:234363
    CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
    cd04641
    Location:390509
    CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
    cl28033
    Location:2177
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
  11. XM_017012281.2XP_016867770.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X20

    Conserved Domains (2) summary
    cd04618
    Location:8145
    CBS_euAMPK_gamma-like_repeat1; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in AMP-activated protein kinase gamma-like proteins, repeat 1
    cd04641
    Location:171294
    CBS_euAMPK_gamma-like_repeat2; CBS pair domain found in 5'-AMP (adenosine monophosphate)-activated protein kinase
  12. XM_017012276.2XP_016867765.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X18

    Conserved Domains (2) summary
    cd04618
    Location:36165
    CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
    cd04641
    Location:192311
    CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
  13. XM_024446788.1XP_024302556.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X14

    Conserved Domains (2) summary
    cd04618
    Location:36165
    CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
    cd04641
    Location:192311
    CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
  14. XM_024446789.1XP_024302557.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X17

    Related
    ENSP00000499103.1, ENST00000651378.1
    Conserved Domains (2) summary
    cd04618
    Location:37166
    CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
    cd04641
    Location:193312
    CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
  15. XM_024446787.1XP_024302555.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X13

    Conserved Domains (2) summary
    cd04618
    Location:37166
    CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
    cd04641
    Location:193312
    CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
  16. XM_017012272.1XP_016867761.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X10

  17. XM_017012270.1XP_016867759.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X9

    UniProtKB/Swiss-Prot
    Q9UGJ0
    Related
    ENSP00000499025.1, ENST00000652159.1
    Conserved Domains (3) summary
    cd04618
    Location:234363
    CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
    cd04641
    Location:390509
    CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
    cl28033
    Location:2177
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
  18. XM_024446786.1XP_024302554.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X6

    Conserved Domains (3) summary
    cd04618
    Location:234363
    CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
    cd04641
    Location:390509
    CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
    cl28033
    Location:2177
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
  19. XM_011516284.1XP_011514586.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X5

    Conserved Domains (3) summary
    COG0517
    Location:354474
    CBS; CBS domain [Signal transduction mechanisms]
    cd04618
    Location:273402
    CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
    cd04641
    Location:429548
    CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
  20. XM_011516282.1XP_011514584.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X2

    Conserved Domains (3) summary
    COG0517
    Location:354474
    CBS; CBS domain [Signal transduction mechanisms]
    cd04618
    Location:273402
    CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
    cd04641
    Location:429548
    CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
  21. XM_011516283.1XP_011514585.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X4

    Conserved Domains (3) summary
    COG0517
    Location:355475
    CBS; CBS domain [Signal transduction mechanisms]
    cd04618
    Location:274403
    CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
    cd04641
    Location:430549
    CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
  22. XM_006716021.2XP_006716084.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X1

    Conserved Domains (3) summary
    COG0517
    Location:355475
    CBS; CBS domain [Signal transduction mechanisms]
    cd04618
    Location:274403
    CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
    cd04641
    Location:430549
    CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
  23. XM_005250006.5XP_005250063.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X11

    Conserved Domains (3) summary
    COG0517
    Location:235355
    CBS; CBS domain [Signal transduction mechanisms]
    cd04618
    Location:154283
    CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
    cd04641
    Location:310429
    CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
  24. XM_017012274.2XP_016867763.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X14

    Conserved Domains (2) summary
    cd04618
    Location:36165
    CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
    cd04641
    Location:192311
    CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
  25. XM_011516285.2XP_011514587.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X13

    Conserved Domains (2) summary
    cd04618
    Location:37166
    CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
    cd04641
    Location:193312
    CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
  26. XM_017012277.2XP_016867766.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X19

    Related
    ENST00000650851.1
  27. XM_011516286.2XP_011514588.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X15

    Conserved Domains (3) summary
    COG0517
    Location:110230
    CBS; CBS domain [Signal transduction mechanisms]
    cd04618
    Location:29158
    CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
    cd04641
    Location:185304
    CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
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