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GHSR growth hormone secretagogue receptor [ Bos taurus (domestic cattle) ]

Gene ID: 514203, updated on 30-Jan-2025
Official Symbol
GHSRprovided by VGNC
Official Full Name
growth hormone secretagogue receptorprovided by VGNC
Primary source
VGNC:VGNC:29352
See related
BGD:BT12745; EnsemblRapid:ENSBTAG00070001727
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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See GHSR in Genome Data Viewer
Location:
chromosome: 1
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 1 NC_037328.1 (95028001..95037403)

Chromosome 1 - NC_037328.1Genomic Context describing neighboring genes Neighboring gene neutral cholesterol ester hydrolase 1 Neighboring gene TNF superfamily member 10 Neighboring gene uncharacterized LOC101905019 Neighboring gene transfer RNA cysteine (anticodon ACA)

Genomic Sequence:
NC_037328.1 Chromosome 1 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. Overdominance effect of the bovine ghrelin receptor (GHSR1a)-DelR242 locus on growth in Japanese Shorthorn weaner bulls: heterozygote advantage in bull selection and molecular mechanisms. Komatsu M, et al. G3 (Bethesda), 2014 Dec 23. PMID 25538099, Free PMC Article
  2. Age-related changes in gene expression of the growth hormone secretagogue and growth hormone-releasing hormone receptors in Holstein-Friesian cattle. Komatsu M, et al. Domest Anim Endocrinol, 2012 Feb. PMID 22056236
  3. Nucleotide polymorphisms and the 5'-UTR transcriptional analysis of the bovine growth hormone secretagogue receptor 1a (GHSR1a) gene. Komatsu M, et al. Anim Sci J, 2010 Oct. PMID 20887305
  4. Genomic location of the bovine growth hormone secretagogue receptor (GHSR) gene and investigation of genetic polymorphism. Colinet FG, et al. Anim Biotechnol, 2009. PMID 19160085
  5. Epistatic effects between pairs of the growth hormone secretagogue receptor 1a, growth hormone, growth hormone receptor, non-SMC condensin I complex, subunit G and stearoyl-CoA desaturase genes on carcass, price-related and fatty acid composition traits in Japanese Black cattle. Komatsu M, et al. Anim Sci J, 2018 Feb. PMID 29154485

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GHSR1a.5'UTR-(TG)n locus plays a central role in gene-gene epistatic interaction of FA composition traits in the adipose tissue of Japanese Black cattle.
    Title: Epistatic effects between pairs of the growth hormone secretagogue receptor 1a, growth hormone, growth hormone receptor, non-SMC condensin I complex, subunit G and stearoyl-CoA desaturase genes on carcass, price-related and fatty acid composition traits in Japanese Black cattle.
  2. The effects of dietary energy on the metabolism of ghrelin, leptin and growth hormone secretagogue receptor in blood and tissues of steers are reported.
    Title: Circulating ghrelin and leptin concentrations and growth hormone secretagogue receptor abundance in liver, muscle, and adipose tissue of beef cattle exhibiting differences in composition of gain.
  3. The coding regions of GHSR and SLC2A2 were sequenced in 12 animals with extreme phenotypes for feed intake and gain; Sixteen SNPs were identified in SLC2A2, and three were detected in GHSR.
    Title: Evaluation of polymorphisms within the genes GHSR and SLC2A2 that are within a region on bovine chromosome 1 (BTA1) previously associated with feed intake and weight gain.
  4. provided conclusive evidence that the 19-TG allele of the 5'UTR microsatellite of the bovine GHSR1a gene affects growth and carcass traits in Japanese Black cattle
    Title: Genetic association between GHSR1a 5'UTR-microsatellite and nt-7(C>A) loci and growth and carcass traits in Japanese Black cattle.
  5. We evaluated the haplotype variety and characterized the microsatellite ((TG)(n) , 5'-UTR) and nucleotide polymorphisms of the bovine GHSR1a gene.
    Title: Nucleotide polymorphisms and the 5'-UTR transcriptional analysis of the bovine growth hormone secretagogue receptor 1a (GHSR1a) gene.
  6. Six polymorphisms (five SNPs and one 3-bp indel) were identified, three of them leading to amino acid variations L24V, D194N, and Del R242.
    Title: Genomic location of the bovine growth hormone secretagogue receptor (GHSR) gene and investigation of genetic polymorphism.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables growth hormone secretagogue receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in hormone-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
growth hormone secretagogue receptor type 1
Names
growth hormone secretagogue receptor type 1B
growth hormone secretagogue receptor type 1a-like protein
growth hormone secretagogue receptor, type 1A

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001143736.2 → NP_001137208.1  growth hormone secretagogue receptor type 1

    See identical proteins and their annotated locations for NP_001137208.1

    Status: PROVISIONAL

    Source sequence(s)
    AB236903
    UniProtKB/TrEMBL
    B5U8Y5, C1PHZ1, C1PI23
    Related
    ENSBTAP00070002231.1, ENSBTAT00070004003.1
    Conserved Domains (1) summary
    cd15131
    Location:45 → 334
    7tmA_GHSR; growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037328.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    95028001..95037403
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_010801372.3 → XP_010799674.1  growth hormone secretagogue receptor type 1 isoform X1

    See identical proteins and their annotated locations for XP_010799674.1

    UniProtKB/TrEMBL
    B5U8Y5, C1PHZ1, C1PI23
    Conserved Domains (1) summary
    cd15131
    Location:45 → 334
    7tmA_GHSR; growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
Nucleotide Protein Strain
Heading Accession and Version

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