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ACTL6B actin like 6B [ Homo sapiens (human) ]

Gene ID: 51412, updated on 5-Apr-2020

Summary

Official Symbol
ACTL6Bprovided by HGNC
Official Full Name
actin like 6Bprovided by HGNC
Primary source
HGNC:HGNC:160
See related
Ensembl:ENSG00000077080 MIM:612458
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ACTL6; BAF53B; EIEE76; IDDSSAD; arpNalpha
Summary
The protein encoded by this gene is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a subunit of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. This subunit may be involved in the regulation of genes by structural modulation of their chromatin, specifically in the brain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Expression
Biased expression in brain (RPKM 15.4) and adrenal (RPKM 1.2) See more
Orthologs

Genomic context

See ACTL6B in Genome Data Viewer
Location:
7q22.1
Exon count:
14
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (100643097..100656448, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (100240720..100254084, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene motile sperm domain containing 3 Neighboring gene Sharpr-MPRA regulatory region 4647 Neighboring gene transferrin receptor 2 Neighboring gene uncharacterized LOC105375429 Neighboring gene G protein subunit beta 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of actin-like 6B (ACTL6B; BAF53B) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
structural constituent of cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
transcription coactivator activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
ATP-dependent chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chromatin organization NAS
Non-traceable Author Statement
more info
PubMed 
chromatin remodeling IDA
Inferred from Direct Assay
more info
PubMed 
cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
dendrite development IMP
Inferred from Mutant Phenotype
more info
PubMed 
histone H4 acetylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuron maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of nucleic acid-templated transcription IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
PubMed 
spinal cord development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
NuA4 histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SWI/SNF complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SWI/SNF complex IDA
Inferred from Direct Assay
more info
PubMed 
SWI/SNF complex ISS
Inferred from Sequence or Structural Similarity
more info
 
nBAF complex ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
actin-like protein 6B
Names
53 kDa BRG1-associated factor B
BRG1-associated factor 53B
actin-related protein Baf53b
hArpN alpha

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016188.5NP_057272.1  actin-like protein 6B

    See identical proteins and their annotated locations for NP_057272.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the functional protein.
    Source sequence(s)
    AK314940, BM696009
    Consensus CDS
    CCDS5702.1
    UniProtKB/Swiss-Prot
    O94805
    Related
    ENSP00000160382.5, ENST00000160382.10
    Conserved Domains (1) summary
    pfam00022
    Location:11426
    Actin; Actin

RNA

  1. NR_134539.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate 3' splice site compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK314940, BC008582, BM696009

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    100643097..100656448 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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