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BIN2 bridging integrator 2 [ Homo sapiens (human) ]

Gene ID: 51411, updated on 8-Jul-2021

Summary

Official Symbol
BIN2provided by HGNC
Official Full Name
bridging integrator 2provided by HGNC
Primary source
HGNC:HGNC:1053
See related
Ensembl:ENSG00000110934 MIM:605936
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BRAP-1
Expression
Broad expression in bone marrow (RPKM 30.2), spleen (RPKM 24.4) and 15 other tissues See more
Orthologs
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Genomic context

See BIN2 in Genome Data Viewer
Location:
12q13.13
Exon count:
15
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (51281038..51324668, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (51674822..51718452, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 9853 Neighboring gene DAZ associated protein 2 Neighboring gene uncharacterized LOC102723983 Neighboring gene small cell adhesion glycoprotein Neighboring gene uncharacterized LOC105369767 Neighboring gene chymotrypsin like elastase 1 Neighboring gene polypeptide N-acetylgalactosaminyltransferase 6 Neighboring gene solute carrier family 4 member 8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phospholipid binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cell chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phagocytosis, engulfment IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phagocytosis, engulfment IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in plasma membrane tubulation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in plasma membrane tubulation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in podosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in podosome assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
 
located_in cell junction IEA
Inferred from Electronic Annotation
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in ficolin-1-rich granule lumen TAS
Traceable Author Statement
more info
 
colocalizes_with phagocytic cup IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with phagocytic cup IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
is_active_in podosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in podosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in secretory granule lumen TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
bridging integrator 2
Names
breast cancer associated protein BRAP1
breast cancer-associated protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290007.2NP_001276936.1  bridging integrator 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AB032698, AK300211, BX281612
    Consensus CDS
    CCDS76561.1
    UniProtKB/Swiss-Prot
    Q9UBW5
    UniProtKB/TrEMBL
    B7Z6F3, F5H0W4
    Related
    ENSP00000445874.1, ENST00000544402.5
    Conserved Domains (1) summary
    cd07612
    Location:4214
    BAR_Bin2; The Bin/Amphiphysin/Rvs (BAR) domain of Bridging integrator 2
  2. NM_001290008.2NP_001276937.2  bridging integrator 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AB032698, AK000783, BX281612, DB035315
    Related
    ENSP00000410217.3, ENST00000452142.7
    Conserved Domains (2) summary
    cl12013
    Location:30208
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    cl28033
    Location:231451
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
  3. NM_001290009.2NP_001276938.1  bridging integrator 2 isoform 4

    See identical proteins and their annotated locations for NP_001276938.1

    Status: VALIDATED

    Source sequence(s)
    AB032698, AK225911, BX281612, DB035315
    UniProtKB/Swiss-Prot
    Q9UBW5
    Related
    ENST00000605039.5
    Conserved Domains (2) summary
    cl12013
    Location:1116
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    cl28033
    Location:139359
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
  4. NM_001364779.1NP_001351708.1  bridging integrator 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC046135
    Conserved Domains (2) summary
    cd07612
    Location:30240
    BAR_Bin2; The Bin/Amphiphysin/Rvs (BAR) domain of Bridging integrator 2
    cl28033
    Location:251482
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
  5. NM_001364780.1NP_001351709.1  bridging integrator 2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC046135
    Related
    ENSP00000474972.3, ENST00000604560.6
    Conserved Domains (2) summary
    cd07612
    Location:30240
    BAR_Bin2; The Bin/Amphiphysin/Rvs (BAR) domain of Bridging integrator 2
    cl25496
    Location:264536
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
  6. NM_001364781.1NP_001351710.1  bridging integrator 2 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC046135
    Conserved Domains (2) summary
    cl12013
    Location:30201
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    cl28033
    Location:193429
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
  7. NM_016293.4NP_057377.4  bridging integrator 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AB032698, AF146531, BX281612, DB035315
    Consensus CDS
    CCDS8811.2
    Related
    ENSP00000483983.2, ENST00000615107.6
    Conserved Domains (2) summary
    cd07612
    Location:30240
    BAR_Bin2; The Bin/Amphiphysin/Rvs (BAR) domain of Bridging integrator 2
    cl28033
    Location:263483
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    51281038..51324668 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024449016.1XP_024304784.1  bridging integrator 2 isoform X3

    Conserved Domains (2) summary
    cl12013
    Location:1116
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    cl28033
    Location:139359
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

RNA

  1. XR_001748746.1 RNA Sequence

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