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NOL7 nucleolar protein 7 [ Homo sapiens (human) ]

Gene ID: 51406, updated on 9-Feb-2020

Summary

Official Symbol
NOL7provided by HGNC
Official Full Name
nucleolar protein 7provided by HGNC
Primary source
HGNC:HGNC:21040
See related
Ensembl:ENSG00000225921 MIM:611533
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PQBP3; RARG-1; C6orf90; dJ223E5.2
Summary
The protein encoded by this gene localizes to the nucleolus, where it maintains nucleolar structure and cell growth rates. The encoded protein also functions as a tumor suppressor and regulator of angiogenesis. The RB tumor suppressor gene recruits transcription factors to this gene and positively regulates its expression. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2015]
Expression
Ubiquitous expression in testis (RPKM 25.5), thyroid (RPKM 22.2) and 25 other tissues See more
Orthologs

Genomic context

See NOL7 in Genome Data Viewer
Location:
6p23
Exon count:
9
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (13615327..13632470)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (13612531..13633089)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374937 Neighboring gene sirtuin 5 Neighboring gene uncharacterized LOC105374938 Neighboring gene RAN binding protein 9 Neighboring gene Sharpr-MPRA regulatory region 2979 Neighboring gene mitochondrial calcium uniporter regulator 1 Neighboring gene uncharacterized LOC107986571

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC71933

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
Component Evidence Code Pubs
nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
nucleolar protein 7
Names
nucleolar protein 7, 27kDa
nucleolar protein of 27 kDa
polyglutamine binding protein 3
retinoic acid repressible protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317724.1NP_001304653.1  nucleolar protein 7

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AF172066, BU071935
    Consensus CDS
    CCDS4528.1
    UniProtKB/Swiss-Prot
    Q9UMY1
    UniProtKB/TrEMBL
    A0A024QZW2
    Conserved Domains (1) summary
    pfam08157
    Location:172234
    NUC129; NUC129 domain
  2. NM_016167.5NP_057251.2  nucleolar protein 7

    See identical proteins and their annotated locations for NP_057251.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AF172066, BM510944, CX760811
    Consensus CDS
    CCDS4528.1
    UniProtKB/Swiss-Prot
    Q9UMY1
    UniProtKB/TrEMBL
    A0A024QZW2
    Related
    ENSP00000405674.2, ENST00000451315.7
    Conserved Domains (1) summary
    pfam08157
    Location:172234
    NUC129; NUC129 domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    13615327..13632470
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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