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PPME1 protein phosphatase methylesterase 1 [ Homo sapiens (human) ]

Gene ID: 51400, updated on 1-Jun-2020

Summary

Official Symbol
PPME1provided by HGNC
Official Full Name
protein phosphatase methylesterase 1provided by HGNC
Primary source
HGNC:HGNC:30178
See related
Ensembl:ENSG00000214517 MIM:611117
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PME-1; ABDH19
Summary
This gene encodes a protein phosphatase methylesterase localized to the nucleus. The encoded protein acts on the protein phosphatase-2A catalytic subunit and supports the ERK pathway through dephosphorylation of regulatory proteins. It plays a role in malignant glioma progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]
Expression
Ubiquitous expression in testis (RPKM 18.8), brain (RPKM 17.5) and 25 other tissues See more
Orthologs

Genomic context

See PPME1 in Genome Data Viewer
Location:
11q13.4
Exon count:
15
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (74171090..74254703)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (73881936..73965748)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 91 member A1 pseudogene Neighboring gene uncoupling protein 3 Neighboring gene C2 domain containing 3 centriole elongation regulator Neighboring gene uncharacterized LOC105369383 Neighboring gene RNA, 5S ribosomal pseudogene 343 Neighboring gene prolyl 4-hydroxylase subunit alpha 3 Neighboring gene P4HA3 antisense RNA 1 Neighboring gene uncharacterized LOC112268078 Neighboring gene phosphoglucomutase 2 like 1 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 40

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ22226

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cadherin binding HDA PubMed 
protein C-terminal methylesterase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein C-terminal methylesterase activity TAS
Traceable Author Statement
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
protein methylesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphatase 2A binding IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphatase binding IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphatase inhibitor activity TAS
Traceable Author Statement
more info
PubMed 
protein phosphatase regulator activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
negative regulation of phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
protein demethylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein demethylation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
protein phosphatase methylesterase 1
Names
testicular secretory protein Li 39
NP_001258522.1
NP_057231.1
XP_016873402.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271593.2NP_001258522.1  protein phosphatase methylesterase 1 isoform b

    See identical proteins and their annotated locations for NP_001258522.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1. It encodes a longer protein (isoform b) compared to isoform a.
    Source sequence(s)
    AK225647, BC050705, DA824678
    Consensus CDS
    CCDS60891.1
    UniProtKB/Swiss-Prot
    Q9Y570
    Related
    ENSP00000381461.4, ENST00000398427.6
    Conserved Domains (1) summary
    COG0596
    Location:66384
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
  2. NM_016147.3NP_057231.1  protein phosphatase methylesterase 1 isoform a

    See identical proteins and their annotated locations for NP_057231.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (a).
    Source sequence(s)
    AF157028, AK022725
    Consensus CDS
    CCDS44678.1
    UniProtKB/Swiss-Prot
    Q9Y570
    UniProtKB/TrEMBL
    A0A140VK39
    Related
    ENSP00000329867.8, ENST00000328257.13
    Conserved Domains (1) summary
    COG0596
    Location:66370
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    74171090..74254703
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017017913.2XP_016873402.1  protein phosphatase methylesterase 1 isoform X1

RNA

  1. XR_428916.2 RNA Sequence

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