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PDE3B phosphodiesterase 3B [ Homo sapiens (human) ]

Gene ID: 5140, updated on 24-Nov-2020

Summary

Official Symbol
PDE3Bprovided by HGNC
Official Full Name
phosphodiesterase 3Bprovided by HGNC
Primary source
HGNC:HGNC:8779
See related
Ensembl:ENSG00000152270 MIM:602047
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HcGIP1; cGIPDE1
Expression
Biased expression in fat (RPKM 53.0), lymph node (RPKM 8.6) and 12 other tissues See more
Orthologs

Genomic context

See PDE3B in Genome Data Viewer
Location:
11p15.2
Exon count:
18
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (14643691..14874139)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (14665191..14893605)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene COPI coat complex subunit beta 1 Neighboring gene RNA, U7 small nuclear 49 pseudogene Neighboring gene proteasome 20S subunit alpha 1 Neighboring gene mortality factor 4 like 1 pseudogene 3 Neighboring gene uncharacterized LOC107984315 Neighboring gene cytochrome P450 family 2 subfamily R member 1 Neighboring gene calcitonin pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study of vitamin D levels in children: replication in the Western Australian Pregnancy Cohort (Raine) study.
GeneReviews: Not available
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat decreases the intracellular levels of cAMP and CREB ser-133 phosphorylation through a signal transduction pathway involving sequential activation of phosphatidylinositol 3-kinase, AKT, and cyclic nucleoside phosphodiesterases PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
3',5'-cyclic-AMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
3',5'-cyclic-nucleotide phosphodiesterase activity EXP
Inferred from Experiment
more info
PubMed 
3',5'-cyclic-nucleotide phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
3',5'-cyclic-nucleotide phosphodiesterase activity TAS
Traceable Author Statement
more info
PubMed 
cGMP-inhibited cyclic-nucleotide phosphodiesterase activity TAS
Traceable Author Statement
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase B binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein kinase B binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
cellular response to insulin stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cAMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of cAMP-mediated signaling TAS
Traceable Author Statement
more info
PubMed 
negative regulation of cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell adhesion mediated by integrin IC
Inferred by Curator
more info
PubMed 
negative regulation of lipid catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol TAS
Traceable Author Statement
more info
 
endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
guanyl-nucleotide exchange factor complex IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cGMP-inhibited 3',5'-cyclic phosphodiesterase B
Names
CGI-PDE B
CGIP1
cyclic GMP-inhibited phosphodiesterase B
cyclic nucleotide phosphodiesterase
phosphodiesterase 3B, cGMP-inhibited
NP_000913.2
NP_001350498.1
NP_001350499.1
XP_006718312.1
XP_016873400.1
XP_016873401.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000922.4NP_000913.2  cGMP-inhibited 3',5'-cyclic phosphodiesterase B isoform 2

    See identical proteins and their annotated locations for NP_000913.2

    Status: VALIDATED

    Source sequence(s)
    AC090835, BC136565, BC150307
    Consensus CDS
    CCDS7817.1
    UniProtKB/Swiss-Prot
    Q13370
    UniProtKB/TrEMBL
    A7E2E5
    Related
    ENSP00000282096.4, ENST00000282096.9
    Conserved Domains (2) summary
    pfam00233
    Location:7361010
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam06532
    Location:136282
    DUF1109; Protein of unknown function (DUF1109)
  2. NM_001363569.2NP_001350498.1  cGMP-inhibited 3',5'-cyclic phosphodiesterase B isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC018795, AC087207, AC090835
    Related
    ENSP00000388644.2, ENST00000455098.2
    Conserved Domains (2) summary
    pfam00233
    Location:685959
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam06532
    Location:136282
    DUF1109; Protein of unknown function (DUF1109)
  3. NM_001363570.2NP_001350499.1  cGMP-inhibited 3',5'-cyclic phosphodiesterase B isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC018795, AC087207, AC090835
    Conserved Domains (2) summary
    pfam00233
    Location:8141088
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam06532
    Location:136282
    DUF1109; Protein of unknown function (DUF1109)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    14643691..14874139
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017017911.2XP_016873400.1  cGMP-inhibited 3',5'-cyclic phosphodiesterase B isoform X1

  2. XM_017017912.1XP_016873401.1  cGMP-inhibited 3',5'-cyclic phosphodiesterase B isoform X2

  3. XM_006718249.3XP_006718312.1  cGMP-inhibited 3',5'-cyclic phosphodiesterase B isoform X3

    Conserved Domains (1) summary
    pfam06532
    Location:136282
    DUF1109; Protein of unknown function (DUF1109)

RNA

  1. XR_001747903.2 RNA Sequence

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