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PDE3B phosphodiesterase 3B [ Homo sapiens (human) ]

Gene ID: 5140, updated on 22-Sep-2022

Summary

Official Symbol
PDE3Bprovided by HGNC
Official Full Name
phosphodiesterase 3Bprovided by HGNC
Primary source
HGNC:HGNC:8779
See related
Ensembl:ENSG00000152270 MIM:602047; AllianceGenome:HGNC:8779
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HcGIP1; cGIPDE1
Summary
Enables 3',5'-cyclic-nucleotide phosphodiesterase activity. Involved in negative regulation of angiogenesis; negative regulation of cell adhesion; and negative regulation of lipid catabolic process. Located in membrane. Part of guanyl-nucleotide exchange factor complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in fat (RPKM 53.0), lymph node (RPKM 8.6) and 12 other tissues See more
Orthologs
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Genomic context

See PDE3B in Genome Data Viewer
Location:
11p15.2
Exon count:
17
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (14643804..14872044)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (14739099..14968415)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (14665350..14893590)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene COPI coat complex subunit beta 1 Neighboring gene RNA, U7 small nuclear 49 pseudogene Neighboring gene proteasome 20S subunit alpha 1 Neighboring gene mortality factor 4 like 1 pseudogene 3 Neighboring gene uncharacterized LOC107984315 Neighboring gene uncharacterized LOC124902639 Neighboring gene uncharacterized LOC124902638 Neighboring gene cytochrome P450 family 2 subfamily R member 1 Neighboring gene calcitonin pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study of vitamin D levels in children: replication in the Western Australian Pregnancy Cohort (Raine) study.
EBI GWAS Catalog
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat decreases the intracellular levels of cAMP and CREB ser-133 phosphorylation through a signal transduction pathway involving sequential activation of phosphatidylinositol 3-kinase, AKT, and cyclic nucleoside phosphodiesterases PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in Golgi apparatus ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of guanyl-nucleotide exchange factor complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane HDA PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B
Names
CGI-PDE B
CGIP1
cyclic GMP-inhibited phosphodiesterase B
cyclic nucleotide phosphodiesterase
phosphodiesterase 3B, cGMP-inhibited
NP_000913.2
NP_001350498.1
NP_001350499.1
XP_006718312.1
XP_047283071.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000922.4NP_000913.2  cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B isoform 2

    See identical proteins and their annotated locations for NP_000913.2

    Status: VALIDATED

    Source sequence(s)
    AC090835, BC136565, BC150307
    Consensus CDS
    CCDS7817.1
    UniProtKB/Swiss-Prot
    Q13370, Q6SEI4
    UniProtKB/TrEMBL
    A7E2E5
    Related
    ENSP00000282096.4, ENST00000282096.9
    Conserved Domains (2) summary
    pfam00233
    Location:7361010
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam06532
    Location:136282
    DUF1109; Protein of unknown function (DUF1109)
  2. NM_001363569.2NP_001350498.1  cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC018795, AC087207, AC090835
    Related
    ENSP00000388644.2, ENST00000455098.2
    Conserved Domains (2) summary
    pfam00233
    Location:685959
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam06532
    Location:136282
    DUF1109; Protein of unknown function (DUF1109)
  3. NM_001363570.2NP_001350499.1  cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC018795, AC087207, AC090835
    Conserved Domains (2) summary
    pfam00233
    Location:8141088
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam06532
    Location:136282
    DUF1109; Protein of unknown function (DUF1109)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    14643804..14872044
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006718249.4XP_006718312.1  cGMP-inhibited 3',5'-cyclic phosphodiesterase B isoform X1

    Conserved Domains (1) summary
    pfam06532
    Location:136282
    DUF1109; Protein of unknown function (DUF1109)
  2. XM_047427115.1XP_047283071.1  cGMP-inhibited 3',5'-cyclic phosphodiesterase B isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    14739099..14968415
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)