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TRPV2 transient receptor potential cation channel subfamily V member 2 [ Homo sapiens (human) ]

Gene ID: 51393, updated on 3-Sep-2017
Official Symbol
TRPV2provided by HGNC
Official Full Name
transient receptor potential cation channel subfamily V member 2provided by HGNC
Primary source
HGNC:HGNC:18082
See related
Ensembl:ENSG00000187688 MIM:606676; Vega:OTTHUMG00000058989
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
VRL; VRL1; VRL-1
Summary
This gene encodes an ion channel that is activated by high temperatures above 52 degrees Celsius. The protein may be involved in transduction of high-temperature heat responses in sensory ganglia. It is thought that in other tissues the channel may be activated by stimuli other than heat. [provided by RefSeq, Jul 2008]
Orthologs
Location:
17p11.2
Exon count:
16
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 17 NC_000017.11 (16415542..16437003)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (16318856..16340317)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ubiquitin B Neighboring gene ferritin light chain pseudogene 12 Neighboring gene LRRC75A antisense RNA 1 Neighboring gene small nucleolar RNA, C/D box 49B Neighboring gene small nucleolar RNA, C/D box 49A

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of transient receptor potential cation channel V, member 2 (TRPV2) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

Go to the HIV-1, Human Interaction Database

  • Inflammatory mediator regulation of TRP channels, organism-specific biosystem (from KEGG)
    Inflammatory mediator regulation of TRP channels, organism-specific biosystemThe TRP channels that exhibit a unique response to temperature have been given the name thermo-TRPs. Among all thermo- TRP channels, TRPV1-4, TRPM8, and TRPA1 are expressed in subsets of nociceptive...
  • Inflammatory mediator regulation of TRP channels, conserved biosystem (from KEGG)
    Inflammatory mediator regulation of TRP channels, conserved biosystemThe TRP channels that exhibit a unique response to temperature have been given the name thermo-TRPs. Among all thermo- TRP channels, TRPV1-4, TRPM8, and TRPA1 are expressed in subsets of nociceptive...
  • Ion channel transport, organism-specific biosystem (from REACTOME)
    Ion channel transport, organism-specific biosystemIon channels mediate the flow of ions across the plasma membrane of cells. They are integral membrane proteins, typically a multimer of proteins, which, when arranged in the membrane, create a pore f...
  • NOD-like receptor signaling pathway, organism-specific biosystem (from KEGG)
    NOD-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
  • NOD-like receptor signaling pathway, conserved biosystem (from KEGG)
    NOD-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
  • Stimuli-sensing channels, organism-specific biosystem (from REACTOME)
    Stimuli-sensing channels, organism-specific biosystemIon channels that mediate sensations such as pain, warmth, cold, taste pressure and vision. Channels that mediate these sensations include acid-sensing ion channels (ASICs) (Wang & Xu 2011, Qadri et ...
  • TRP channels, organism-specific biosystem (from REACTOME)
    TRP channels, organism-specific biosystemTransient receptor potential (TRP) channel proteins were first discovered in Drosophila melanogaster and have many homologues in other species including humans. TRPs form cationic channels that can ...
  • Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
    Transmembrane transport of small molecules, organism-specific biosystem
    Transmembrane transport of small molecules
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC12549

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
calcium channel activity TAS
Traceable Author Statement
more info
 
cation channel activity IDA
Inferred from Direct Assay
more info
PubMed 
ion channel activity TAS
Traceable Author Statement
more info
PubMed 
ion transmembrane transporter activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
calcium ion transmembrane transport TAS
Traceable Author Statement
more info
 
positive regulation of axon extension IEA
Inferred from Electronic Annotation
more info
 
positive regulation of calcium ion import IEA
Inferred from Electronic Annotation
more info
 
response to heat IEA
Inferred from Electronic Annotation
more info
 
response to temperature stimulus IDA
Inferred from Direct Assay
more info
PubMed 
sensory perception TAS
Traceable Author Statement
more info
PubMed 
transport TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
axonal growth cone IEA
Inferred from Electronic Annotation
more info
 
cell body IEA
Inferred from Electronic Annotation
more info
 
cell surface IEA
Inferred from Electronic Annotation
more info
 
growth cone membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
melanosome IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
transient receptor potential cation channel subfamily V member 2
Names
OTRPC2
osm-9-like TRP channel 2
vanilloid receptor-like protein 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016113.4NP_057197.2  transient receptor potential cation channel subfamily V member 2

    See identical proteins and their annotated locations for NP_057197.2

    Status: REVIEWED

    Source sequence(s)
    AK289705, BC018926
    Consensus CDS
    CCDS32576.1
    UniProtKB/Swiss-Prot
    Q9Y5S1
    Related
    ENSP00000342222.7, OTTHUMP00000064964, ENST00000338560.11, OTTHUMT00000130464
    Conserved Domains (3) summary
    cd00204
    Location:163314
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    TIGR00870
    Location:27764
    trp; transient-receptor-potential calcium channel protein
    sd00045
    Location:162193
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p7 Primary Assembly

    Range
    16415542..16437003
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006721541.3XP_006721604.1  transient receptor potential cation channel subfamily V member 2 isoform X2

    Conserved Domains (3) summary
    cd00204
    Location:163314
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    TIGR00870
    Location:27732
    trp; transient-receptor-potential calcium channel protein
    sd00045
    Location:162193
    ANK; ANK repeat [structural motif]
  2. XM_011523922.1XP_011522224.1  transient receptor potential cation channel subfamily V member 2 isoform X3

    Conserved Domains (3) summary
    cd00204
    Location:163314
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    TIGR00870
    Location:27705
    trp; transient-receptor-potential calcium channel protein
    sd00045
    Location:162193
    ANK; ANK repeat [structural motif]
  3. XM_005256677.1XP_005256734.1  transient receptor potential cation channel subfamily V member 2 isoform X6

    See identical proteins and their annotated locations for XP_005256734.1

    Conserved Domains (3) summary
    cd00204
    Location:163314
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    TIGR00870
    Location:27630
    trp; transient-receptor-potential calcium channel protein
    sd00045
    Location:162193
    ANK; ANK repeat [structural motif]
  4. XM_017024732.1XP_016880221.1  transient receptor potential cation channel subfamily V member 2 isoform X8

  5. XM_005256676.1XP_005256733.1  transient receptor potential cation channel subfamily V member 2 isoform X1

    See identical proteins and their annotated locations for XP_005256733.1

    Conserved Domains (3) summary
    cd00204
    Location:163314
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    TIGR00870
    Location:27763
    trp; transient-receptor-potential calcium channel protein
    sd00045
    Location:162193
    ANK; ANK repeat [structural motif]
  6. XM_017024730.1XP_016880219.1  transient receptor potential cation channel subfamily V member 2 isoform X5

  7. XM_017024731.1XP_016880220.1  transient receptor potential cation channel subfamily V member 2 isoform X7

  8. XM_006721543.3XP_006721606.1  transient receptor potential cation channel subfamily V member 2 isoform X4

    See identical proteins and their annotated locations for XP_006721606.1

    Conserved Domains (5) summary
    cd00204
    Location:163314
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam00520
    Location:452652
    Ion_trans; Ion transport protein
    pfam12796
    Location:114192
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:163229
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:162193
    ANK; ANK repeat [structural motif]
  9. XM_011523923.1XP_011522225.1  transient receptor potential cation channel subfamily V member 2 isoform X10

    Conserved Domains (4) summary
    cd00204
    Location:163314
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:114192
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:163229
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:162193
    ANK; ANK repeat [structural motif]
  10. XM_005256678.4XP_005256735.1  transient receptor potential cation channel subfamily V member 2 isoform X9

    Conserved Domains (4) summary
    cd00204
    Location:163314
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:114192
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:163229
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:162193
    ANK; ANK repeat [structural motif]
  11. XM_011523925.2XP_011522227.1  transient receptor potential cation channel subfamily V member 2 isoform X11

    Conserved Domains (1) summary
    pfam00520
    Location:22222
    Ion_trans; Ion transport protein

Alternate CHM1_1.1

Genomic

  1. NC_018928.2 Alternate CHM1_1.1

    Range
    16328475..16349923
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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