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AIG1 androgen induced 1 [ Homo sapiens (human) ]

Gene ID: 51390, updated on 13-Mar-2020

Summary

Official Symbol
AIG1provided by HGNC
Official Full Name
androgen induced 1provided by HGNC
Primary source
HGNC:HGNC:21607
See related
Ensembl:ENSG00000146416 MIM:608514
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AIG-1; dJ95L4.1
Expression
Ubiquitous expression in liver (RPKM 13.8), kidney (RPKM 9.3) and 24 other tissues See more
Orthologs

Genomic context

See AIG1 in Genome Data Viewer
Location:
6q24.2
Exon count:
17
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (143059363..143343883)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (143381979..143661441)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986655 Neighboring gene long intergenic non-protein coding RNA 1277 Neighboring gene presenilins-associated rhomboid-like protein, mitochondrial-like Neighboring gene ribosomal protein L31 pseudogene 27 Neighboring gene uncharacterized LOC107986656 Neighboring gene chromosome 4 open reading frame 46 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Identification of germline susceptibility loci in ETV6-RUNX1-rearranged childhood acute lymphoblastic leukemia.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10485, DKFZp686F03136

Gene Ontology Provided by GOA

Function Evidence Code Pubs
hydrolase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
long-chain fatty acid catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
androgen-induced gene 1 protein
Names
FAHFA hydrolase AIG1
fatty acid esters of hydroxy fatty acids hydrolase AIG1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286587.1NP_001273516.1  androgen-induced gene 1 protein isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has alternate 5' exon structure and it thus differs in the 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AF151861, AL023581, AL136116, BC025278, BG196820
    UniProtKB/Swiss-Prot
    Q9NVV5
    Conserved Domains (1) summary
    pfam04750
    Location:2209
    Far-17a_AIG1; FAR-17a/AIG1-like protein
  2. NM_001286588.2NP_001273517.1  androgen-induced gene 1 protein isoform c

    See identical proteins and their annotated locations for NP_001273517.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks multiple 3' exons but contains an alternate 3' exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (c) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AK298533, AL023581, BX640703, CA431282, DB154031
    Consensus CDS
    CCDS69215.1
    UniProtKB/Swiss-Prot
    Q9NVV5
    Related
    ENSP00000485875.1, ENST00000629020.2
    Conserved Domains (1) summary
    pfam04750
    Location:12133
    Far-17a_AIG1; FAR-17a/AIG1-like protein
  3. NM_001286589.1NP_001273518.1  androgen-induced gene 1 protein isoform d

    See identical proteins and their annotated locations for NP_001273518.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks multiple 3' exons but contains an alternate 3' exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (d) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AK298533, BM977237, BX640703, CA431282
    Consensus CDS
    CCDS69216.1
    UniProtKB/Swiss-Prot
    Q9NVV5
    Related
    ENSP00000473952.1, ENST00000494282.6
    Conserved Domains (1) summary
    pfam04750
    Location:12134
    Far-17a_AIG1; FAR-17a/AIG1-like protein
  4. NM_001363721.2NP_001350650.1  androgen-induced gene 1 protein isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (e) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AL023581, AL136116, AL391726
    Consensus CDS
    CCDS87450.1
    Related
    ENSP00000493676.1, ENST00000646199.1
    Conserved Domains (1) summary
    pfam04750
    Location:12219
    Far-17a_AIG1; FAR-17a/AIG1-like protein
  5. NM_001366344.1NP_001353273.1  androgen-induced gene 1 protein isoform f precursor

    Status: VALIDATED

    Source sequence(s)
    AL023581, AL136116, AL391726
    Conserved Domains (1) summary
    pfam04750
    Location:12266
    Far-17a_AIG1; FAR-17a/AIG1-like protein
  6. NM_001366345.1NP_001353274.1  androgen-induced gene 1 protein isoform g

    Status: VALIDATED

    Source sequence(s)
    AL023581, AL136116, AL391726
    Conserved Domains (1) summary
    pfam04750
    Location:36243
    Far-17a_AIG1; FAR-17a/AIG1-like protein
  7. NM_001366346.1NP_001353275.1  androgen-induced gene 1 protein isoform h

    Status: VALIDATED

    Source sequence(s)
    AL023581, AL136116, AL391726
    Conserved Domains (1) summary
    pfam04750
    Location:12219
    Far-17a_AIG1; FAR-17a/AIG1-like protein
  8. NM_001366347.1NP_001353276.1  androgen-induced gene 1 protein isoform i

    Status: VALIDATED

    Source sequence(s)
    AL023581, AL136116, AL391726
    Related
    ENSP00000275235.4, ENST00000275235.8
    Conserved Domains (1) summary
    pfam04750
    Location:12219
    Far-17a_AIG1; FAR-17a/AIG1-like protein
  9. NM_001366348.1NP_001353277.1  androgen-induced gene 1 protein isoform j

    Status: VALIDATED

    Source sequence(s)
    AL023581, AL136116, AL391726
    Conserved Domains (1) summary
    pfam04750
    Location:12219
    Far-17a_AIG1; FAR-17a/AIG1-like protein
  10. NM_001366349.2NP_001353278.1  androgen-induced gene 1 protein isoform k

    Status: VALIDATED

    Source sequence(s)
    AL023581, AL136116, AL391726
    Conserved Domains (1) summary
    pfam04750
    Location:12219
    Far-17a_AIG1; FAR-17a/AIG1-like protein
  11. NM_001366350.1NP_001353279.1  androgen-induced gene 1 protein isoform l

    Status: VALIDATED

    Source sequence(s)
    AL023581, AL136116, AL391726
    Conserved Domains (1) summary
    pfam04750
    Location:12219
    Far-17a_AIG1; FAR-17a/AIG1-like protein
  12. NM_001366351.1NP_001353280.1  androgen-induced gene 1 protein isoform m

    Status: VALIDATED

    Source sequence(s)
    AL023581, AL136116, AL391726
    Related
    ENSP00000356573.4, ENST00000367601.8
    Conserved Domains (1) summary
    pfam04750
    Location:8215
    Far-17a_AIG1; FAR-17a/AIG1-like protein
  13. NM_001366352.1NP_001353281.1  androgen-induced gene 1 protein isoform n

    Status: VALIDATED

    Source sequence(s)
    AL023581, AL136116, AL391726
    Conserved Domains (1) summary
    pfam04750
    Location:36157
    Far-17a_AIG1; FAR-17a/AIG1-like protein
  14. NM_001366353.1NP_001353282.1  androgen-induced gene 1 protein isoform o

    Status: VALIDATED

    Source sequence(s)
    AL023581, AL136116
    Conserved Domains (1) summary
    pfam04750
    Location:12185
    Far-17a_AIG1; FAR-17a/AIG1-like protein
  15. NM_001366354.1NP_001353283.1  androgen-induced gene 1 protein isoform p

    Status: VALIDATED

    Source sequence(s)
    AL023581, AL136116, AL391726
    Conserved Domains (1) summary
    pfam04750
    Location:12133
    Far-17a_AIG1; FAR-17a/AIG1-like protein
  16. NM_001366355.1NP_001353284.1  androgen-induced gene 1 protein isoform q

    Status: VALIDATED

    Source sequence(s)
    AL023581, AL136116, AL391726
    Conserved Domains (1) summary
    pfam04750
    Location:12167
    Far-17a_AIG1; FAR-17a/AIG1-like protein
  17. NM_001366356.1NP_001353285.1  androgen-induced gene 1 protein isoform r precursor

    Status: VALIDATED

    Source sequence(s)
    AL023581, AL391726
    Conserved Domains (1) summary
    pfam04750
    Location:12181
    Far-17a_AIG1; FAR-17a/AIG1-like protein
  18. NM_001366357.1NP_001353286.1  androgen-induced gene 1 protein isoform s

    Status: VALIDATED

    Source sequence(s)
    AL023581, AL136116, AL391726
    Conserved Domains (1) summary
    pfam04750
    Location:12172
    Far-17a_AIG1; FAR-17a/AIG1-like protein
  19. NM_001366358.1NP_001353287.1  androgen-induced gene 1 protein isoform t

    Status: VALIDATED

    Source sequence(s)
    AL023581, AL136116, AL391726
    Related
    ENSP00000407817.1, ENST00000458219.1
    Conserved Domains (1) summary
    pfam04750
    Location:1131
    Far-17a_AIG1; FAR-17a/AIG1-like protein
  20. NM_001366359.1NP_001353288.1  androgen-induced gene 1 protein isoform u

    Status: VALIDATED

    Source sequence(s)
    AL023581, AL391726
    Conserved Domains (1) summary
    pfam04750
    Location:8130
    Far-17a_AIG1; FAR-17a/AIG1-like protein
  21. NM_001366361.1NP_001353290.1  androgen-induced gene 1 protein isoform v

    Status: VALIDATED

    Source sequence(s)
    AL136116, AL391726
    Conserved Domains (1) summary
    pfam04750
    Location:1105
    Far-17a_AIG1; FAR-17a/AIG1-like protein
  22. NM_001366362.1NP_001353291.1  androgen-induced gene 1 protein isoform w

    Status: VALIDATED

    Source sequence(s)
    AL023581
    Conserved Domains (1) summary
    pfam04750
    Location:3671
    Far-17a_AIG1; FAR-17a/AIG1-like protein
  23. NM_001366363.1NP_001353292.1  androgen-induced gene 1 protein isoform x precursor

    Status: VALIDATED

    Source sequence(s)
    AL023581
    Related
    ENSP00000356568.1, ENST00000367596.5
    Conserved Domains (1) summary
    pfam04750
    Location:1247
    Far-17a_AIG1; FAR-17a/AIG1-like protein
  24. NM_016108.4NP_057192.2  androgen-induced gene 1 protein isoform a

    See identical proteins and their annotated locations for NP_057192.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform a.
    Source sequence(s)
    AK298533, AL136116, BC025278, BG196820
    Consensus CDS
    CCDS5198.1
    UniProtKB/Swiss-Prot
    Q9NVV5
    Related
    ENSP00000350509.4, ENST00000357847.9
    Conserved Domains (1) summary
    pfam04750
    Location:12219
    Far-17a_AIG1; FAR-17a/AIG1-like protein

RNA

  1. NR_158896.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL023581, AL136116, AL391726
  2. NR_158960.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL023581, AL136116, AL391726

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    143059363..143343883
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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