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RWDD1 RWD domain containing 1 [ Homo sapiens (human) ]

Gene ID: 51389, updated on 5-Aug-2022

Summary

Official Symbol
RWDD1provided by HGNC
Official Full Name
RWD domain containing 1provided by HGNC
Primary source
HGNC:HGNC:20993
See related
Ensembl:ENSG00000111832 AllianceGenome:HGNC:20993
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CGI-24; PTD013
Summary
Predicted to be involved in several processes, including cellular response to lipid; cytoplasmic translation; and positive regulation of androgen receptor activity. Predicted to be located in cytoplasm. Predicted to be part of polysome. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in fat (RPKM 22.0), adrenal (RPKM 19.3) and 25 other tissues See more
Orthologs
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Genomic context

See RWDD1 in Genome Data Viewer
Location:
6q22.1
Exon count:
10
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (116571504..116597675)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (117755215..117781381)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (116892667..116918838)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene trafficking protein particle complex subunit 3L Neighboring gene calcium homeostasis modulator family member 5 Neighboring gene calcium homeostasis modulator family member 4 Neighboring gene uncharacterized LOC124901386 Neighboring gene radial spoke head component 4A Neighboring gene zinc finger containing ubiquitin peptidase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in androgen receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to testosterone stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cytoplasmic translation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of androgen receptor activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
part_of polysome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
RWD domain-containing protein 1
Names
DRG family-regulatory protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007464.3NP_001007465.1  RWD domain-containing protein 1 isoform b

    See identical proteins and their annotated locations for NP_001007465.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in its 5' UTR, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a. Variants 2 and 3 encode the same isoform.
    Source sequence(s)
    AK301089, AL121953, BC012534, CK817864
    Consensus CDS
    CCDS43496.1
    UniProtKB/Swiss-Prot
    Q9H446
    Related
    ENSP00000428778.1, ENST00000487832.6
    Conserved Domains (1) summary
    pfam16543
    Location:48101
    DFRP_C; DRG Family Regulatory Proteins, Tma46
  2. NM_015952.4NP_057036.2  RWD domain-containing protein 1 isoform a

    See identical proteins and their annotated locations for NP_057036.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AK290727, AK301089, AL121953, CK817864
    Consensus CDS
    CCDS34520.1
    UniProtKB/Swiss-Prot
    Q9H446, Q9Y6B3
    Related
    ENSP00000420357.2, ENST00000466444.7
    Conserved Domains (2) summary
    pfam05773
    Location:6111
    RWD; RWD domain
    pfam16543
    Location:144217
    DFRP_C; DRG Family Regulatory Proteins, Tma46
  3. NM_016104.4NP_057188.2  RWD domain-containing protein 1 isoform b

    See identical proteins and their annotated locations for NP_057188.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in its 5' UTR, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a. Variants 2 and 3 encode the same isoform.
    Source sequence(s)
    AK290727, AK301089, AL121953, CK817864, CN363729
    Consensus CDS
    CCDS43496.1
    UniProtKB/Swiss-Prot
    Q9H446
    Conserved Domains (1) summary
    pfam16543
    Location:48101
    DFRP_C; DRG Family Regulatory Proteins, Tma46

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    116571504..116597675
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047418863.1XP_047274819.1  RWD domain-containing protein 1 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    117755215..117781381
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)