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A2M alpha-2-macroglobulin [ Bos taurus (cattle) ]

Gene ID: 513856, updated on 20-Jun-2018
Official Symbol
A2Mprovided by VGNC
Official Full Name
alpha-2-macroglobulinprovided by VGNC
Primary source
VGNC:VGNC:55837
See related
BGD:BT30437; Ensembl:ENSBTAG00000018137
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
See A2M in Genome Data Viewer
Location:
chromosome: 5
Exon count:
38
Annotation release Status Assembly Chr Location
106 current ARS-UCD1.2 (GCF_002263795.1) 5 NC_037332.1 (100819129..100891539)
105 previous assembly Bos_taurus_UMD_3.1.1 (GCF_000003055.6) 5 AC_000162.1 (101274872..101346613)

Chromosome 5 - NC_037332.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene pregnancy zone protein Neighboring gene killer cell lectin like receptor G1 Neighboring gene ribosomal protein S6 pseudogene Neighboring gene mannose-6-phosphate receptor, cation dependent

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium-dependent protein binding IEA
Inferred from Electronic Annotation
more info
 
interleukin-1 binding IEA
Inferred from Electronic Annotation
more info
 
interleukin-8 binding IEA
Inferred from Electronic Annotation
more info
 
protease binding IEA
Inferred from Electronic Annotation
more info
 
serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
signaling receptor binding IEA
Inferred from Electronic Annotation
more info
 
tumor necrosis factor binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
negative regulation of complement activation, lectin pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
stem cell differentiation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular space IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
alpha-2-macroglobulin
Names
alpha-2-M
alpha-2-macroglobulin variant 10
alpha-2-macroglobulin variant 11
alpha-2-macroglobulin variant 12
alpha-2-macroglobulin variant 13
alpha-2-macroglobulin variant 14
alpha-2-macroglobulin variant 15
alpha-2-macroglobulin variant 16
alpha-2-macroglobulin variant 17
alpha-2-macroglobulin variant 18
alpha-2-macroglobulin variant 19
alpha-2-macroglobulin variant 2
alpha-2-macroglobulin variant 21
alpha-2-macroglobulin variant 23
alpha-2-macroglobulin variant 3
alpha-2-macroglobulin variant 4
alpha-2-macroglobulin variant 5
alpha-2-macroglobulin variant 6
alpha-2-macroglobulin variant 7
alpha-2-macroglobulin variant 8
alpha-2-macroglobulin variant 9

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109795.1NP_001103265.1  alpha-2-macroglobulin precursor

    See identical proteins and their annotated locations for NP_001103265.1

    Status: PROVISIONAL

    Source sequence(s)
    BC153840
    UniProtKB/Swiss-Prot
    Q7SIH1
    Related
    ENSBTAP00000006167.4, ENSBTAT00000006167.4
    Conserved Domains (7) summary
    cd02897
    Location:9951301
    A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
    pfam00207
    Location:740830
    A2M; Alpha-2-macroglobulin family
    pfam01835
    Location:129221
    A2M_N; MG2 domain
    pfam05326
    Location:792884
    SVA; Seminal vesicle autoantigen (SVA)
    pfam07677
    Location:14131499
    A2M_recep; A-macroglobulin receptor
    pfam07678
    Location:10471303
    A2M_comp; A-macroglobulin complement component
    pfam07703
    Location:461606
    A2M_N_2; Alpha-2-macroglobulin family N-terminal region

RefSeqs of Annotated Genomes: Bos taurus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD1.2 Primary Assembly

Genomic

  1. NC_037332.1 Reference ARS-UCD1.2 Primary Assembly

    Range
    100819129..100891539
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005207056.4XP_005207113.1  alpha-2-macroglobulin isoform X1

    Conserved Domains (7) summary
    cd02897
    Location:9951301
    A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
    pfam00207
    Location:740830
    A2M; Alpha-2-macroglobulin family
    pfam01835
    Location:129221
    A2M_N; MG2 domain
    pfam05326
    Location:792884
    SVA; Seminal vesicle autoantigen (SVA)
    pfam07677
    Location:14131499
    A2M_recep; A-macroglobulin receptor
    pfam07678
    Location:10471303
    A2M_comp; A-macroglobulin complement component
    pfam07703
    Location:461606
    A2M_N_2; Alpha-2-macroglobulin family N-terminal region
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