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ZNF589 zinc finger protein 589 [ Homo sapiens (human) ]

Gene ID: 51385, updated on 1-Jun-2020

Summary

Official Symbol
ZNF589provided by HGNC
Official Full Name
zinc finger protein 589provided by HGNC
Primary source
HGNC:HGNC:16747
See related
Ensembl:ENSG00000164048 MIM:616702
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SZF1
Expression
Ubiquitous expression in thyroid (RPKM 4.8), prostate (RPKM 4.7) and 24 other tissues See more
Orthologs

Genomic context

See ZNF589 in Genome Data Viewer
Location:
3p21.31
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (48241104..48270990)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (48282596..48312480)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene microRNA 4443 Neighboring gene cathelicidin antimicrobial peptide Neighboring gene Sharpr-MPRA regulatory region 9849 Neighboring gene mitochondrial ribosomal protein S18A pseudogene 1 Neighboring gene FCF1 pseudogene 2 Neighboring gene NME/NM23 nucleoside diphosphate kinase 6 Neighboring gene serine peptidase inhibitor Kazal type 8 (putative) Neighboring gene microRNA 2115

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 589
Names
KRAB-zinc finger protein SZF1-1
stem cell zinc finger protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016089.3NP_057173.2  zinc finger protein 589

    See identical proteins and their annotated locations for NP_057173.2

    Status: VALIDATED

    Source sequence(s)
    AC104190, AY258146
    Consensus CDS
    CCDS43085.1
    UniProtKB/Swiss-Prot
    Q86UQ0
    Related
    ENSP00000346729.3, ENST00000354698.8
    Conserved Domains (6) summary
    smart00349
    Location:3584
    KRAB; krueppel associated box
    COG5048
    Location:302364
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:250270
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:249270
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:3574
    KRAB; KRAB box
    pfam13465
    Location:291315
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    48241104..48270990
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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