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ZNF589 zinc finger protein 589 [ Homo sapiens (human) ]

Gene ID: 51385, updated on 27-Nov-2024

Summary

Official Symbol
ZNF589provided by HGNC
Official Full Name
zinc finger protein 589provided by HGNC
Primary source
HGNC:HGNC:16747
See related
Ensembl:ENSG00000164048 MIM:616702; AllianceGenome:HGNC:16747
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SZF1
Summary
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in thyroid (RPKM 4.8), prostate (RPKM 4.7) and 24 other tissues See more
Orthologs
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Genomic context

See ZNF589 in Genome Data Viewer
Location:
3p21.31
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (48241104..48270990)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (48268885..48298764)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (48282594..48312480)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:48237715-48238244 Neighboring gene microRNA 4443 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19823 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19824 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19825 Neighboring gene Sharpr-MPRA regulatory region 12857 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:48270677-48271176 Neighboring gene cathelicidin antimicrobial peptide Neighboring gene Sharpr-MPRA regulatory region 8193 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:48282361-48283278 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:48297790-48298360 Neighboring gene mitochondrial ribosomal protein S18A pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14324 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19826 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14325 Neighboring gene FCF1 pseudogene 2 Neighboring gene NME/NM23 nucleoside diphosphate kinase 6 Neighboring gene serine peptidase inhibitor Kazal type 8 (putative) Neighboring gene microRNA 2115

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
zinc finger protein 589
Names
KRAB-zinc finger protein SZF1-1
stem cell zinc finger protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016089.3NP_057173.2  zinc finger protein 589

    See identical proteins and their annotated locations for NP_057173.2

    Status: VALIDATED

    Source sequence(s)
    AC104190, AY258146
    Consensus CDS
    CCDS43085.1
    UniProtKB/Swiss-Prot
    Q86UC9, Q86UQ0, Q9BRI6, Q9BRY3, Q9Y611, Q9Y612
    Related
    ENSP00000346729.3, ENST00000354698.8
    Conserved Domains (6) summary
    smart00349
    Location:3584
    KRAB; krueppel associated box
    COG5048
    Location:302364
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:250270
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:249270
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:3574
    KRAB; KRAB box
    pfam13465
    Location:291315
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    48241104..48270990
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    48268885..48298764
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)