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ANGPT4 angiopoietin 4 [ Homo sapiens (human) ]

Gene ID: 51378, updated on 13-Mar-2020

Summary

Official Symbol
ANGPT4provided by HGNC
Official Full Name
angiopoietin 4provided by HGNC
Primary source
HGNC:HGNC:487
See related
Ensembl:ENSG00000101280 MIM:603705
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ANG3; ANG4
Summary
Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The mechanism by which they contribute to angiogenesis is thought to involve regulation of endothelial cell interactions with supporting perivascular cells. The protein encoded by this gene functions as an agonist and is an angiopoietin. [provided by RefSeq, Jul 2008]
Expression
Biased expression in fat (RPKM 1.7), ovary (RPKM 1.2) and 11 other tissues See more
Orthologs

Genomic context

See ANGPT4 in Genome Data Viewer
Location:
20p13
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (869900..916368, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (852763..896977, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr20.80 Neighboring gene family with sequence similarity 110 member A Neighboring gene ribosomal protein S10 pseudogene 5 Neighboring gene uncharacterized LOC105372492 Neighboring gene R-spondin 4 Neighboring gene Sharpr-MPRA regulatory region 1111

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC138181, MGC138183

Gene Ontology Provided by GOA

Function Evidence Code Pubs
receptor tyrosine kinase binding IDA
Inferred from Direct Assay
more info
PubMed 
transmembrane receptor protein tyrosine kinase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001322809.2NP_001309738.1  angiopoietin-4 isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AK304756, AL161939, BM999095
    UniProtKB/Swiss-Prot
    Q9Y264
    Conserved Domains (1) summary
    cd00087
    Location:288410
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
  2. NM_015985.4NP_057069.1  angiopoietin-4 isoform 1 precursor

    See identical proteins and their annotated locations for NP_057069.1

    Status: REVIEWED

    Source sequence(s)
    AF074332, AK304756, AL161939, BM999095
    Consensus CDS
    CCDS13009.1
    UniProtKB/Swiss-Prot
    Q9Y264
    Related
    ENSP00000371347.3, ENST00000381922.5
    Conserved Domains (1) summary
    cd00087
    Location:288501
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    869900..916368 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011529239.3XP_011527541.1  angiopoietin-4 isoform X1

    Conserved Domains (1) summary
    cd00087
    Location:236449
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
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