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ATRAID all-trans retinoic acid induced differentiation factor [ Homo sapiens (human) ]

Gene ID: 51374, updated on 5-May-2020

Summary

Official Symbol
ATRAIDprovided by HGNC
Official Full Name
all-trans retinoic acid induced differentiation factorprovided by HGNC
Primary source
HGNC:HGNC:24090
See related
Ensembl:ENSG00000138085
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p18; APR3; APR-3; APR--3; PRO240; C2orf28; HSPC013
Summary
This gene is thought to be involved in apoptosis, and may also be involved in hematopoietic development and differentiation. The use of alternative splice sites and promotors result in multiple transcript variants encoding different isoforms.[provided by RefSeq, Dec 2009]
Expression
Ubiquitous expression in thyroid (RPKM 48.2), testis (RPKM 45.1) and 25 other tissues See more
Orthologs

Genomic context

See ATRAID in Genome Data Viewer
Location:
2p23.3
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (27212360..27217183)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (27434899..27440046)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene transcription factor 23 Neighboring gene solute carrier family 5 member 6 Neighboring gene carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase Neighboring gene solute carrier family 30 member 3 Neighboring gene DnaJ heat shock protein family (Hsp40) member C5 gamma

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef The yeast two-hybrid screen identifies the HIV-1 Nef interacting human protein all-trans retinoic acid-induced differentiation factor (ATRAID; APR-3) in cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
lysosomal membrane IEA
Inferred from Electronic Annotation
more info
 
nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
all-trans retinoic acid-induced differentiation factor
Names
apoptosis related protein APR-3
apoptosis-related protein 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001170795.3NP_001164266.1  all-trans retinoic acid-induced differentiation factor isoform c precursor

    See identical proteins and their annotated locations for NP_001164266.1

    Status: REVIEWED

    Source sequence(s)
    AC013403
    Consensus CDS
    CCDS62877.1
    UniProtKB/Swiss-Prot
    Q6UW56
    Related
    ENSP00000369518.3, ENST00000380171.7
  2. NM_016085.5NP_057169.2  all-trans retinoic acid-induced differentiation factor isoform a

    See identical proteins and their annotated locations for NP_057169.2

    Status: REVIEWED

    Source sequence(s)
    AC013403
    Consensus CDS
    CCDS46243.1
    UniProtKB/Swiss-Prot
    Q6UW56
    Related
    ENSP00000384033.3, ENST00000405489.7

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    27212360..27217183
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_080592.3: Suppressed sequence

    Description
    NM_080592.3: This RefSeq was removed because currently there is support for the transcript but not for the protein.
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