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TEX264 testis expressed 264, ER-phagy receptor [ Homo sapiens (human) ]

Gene ID: 51368, updated on 3-May-2020

Summary

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Official Symbol
TEX264provided by HGNC
Official Full Name
testis expressed 264, ER-phagy receptorprovided by HGNC
Primary source
HGNC:HGNC:30247
See related
Ensembl:ENSG00000164081
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZSIG11
Expression
Ubiquitous expression in testis (RPKM 25.1), kidney (RPKM 16.6) and 25 other tissues See more
Orthologs
mouse all

Genomic context

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See TEX264 in Genome Data Viewer
Location:
3p21.2
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (51671175..51704323)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (51705191..51738339)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene RAD54 like 2 Neighboring gene RNA, U6atac small nuclear 29, pseudogene Neighboring gene uncharacterized LOC105377086 Neighboring gene RNA, 5S ribosomal pseudogene 132 Neighboring gene glutamate metabotropic receptor 2 Neighboring gene uncharacterized LOC105377087 Neighboring gene IQ motif containing F6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. TEX264 Is an Endoplasmic Reticulum-Resident ATG8-Interacting Protein Critical for ER Remodeling during Nutrient Stress. An H, et al. Mol Cell, 2019 Jun 6. PMID 31006537,
  2. Intrinsically Disordered Protein TEX264 Mediates ER-phagy. Chino H, et al. Mol Cell, 2019 Jun 6. PMID 31006538
  3. Mouse Fem1b interacts with the Nkx3.1 homeoprotein and is required for proper male secondary sexual development. Wang X, et al. Dev Dyn, 2008 Oct. PMID 18816836, Free PMC Article
  4. The interactome of metabolic enzyme carbonic anhydrase IX reveals novel roles in tumor cell migration and invadopodia/MMP14-mediated invasion. Swayampakula M, et al. Oncogene, 2017 Nov 9. PMID 28692057, Free PMC Article
  5. Spatial proteomics reveal that the protein phosphatase PTP1B interacts with and may modify tyrosine phosphorylation of the rhomboid protease RHBDL4. Ikeda KN, et al. J Biol Chem, 2019 Jul 26. PMID 31177093, Free PMC Article

See all (27) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ13935, DKFZp451H0417

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
platelet degranulation TAS
Traceable Author Statement
more info
  
reticulophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
autophagosome membrane IDA
Inferred from Direct Assay
more info
 PubMed 
endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
extracellular region TAS
Traceable Author Statement
more info
  
integral component of membrane IEA
Inferred from Electronic Annotation
more info
  
platelet alpha granule lumen TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
testis-expressed protein 264
Names
testis expressed 264
testis expressed gene 264
testis-expressed sequence 264 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001129884.2 → NP_001123356.1  testis-expressed protein 264 isoform 1

    See identical proteins and their annotated locations for NP_001123356.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 4, 5, and 7 encode the same isoform (1).
    Source sequence(s)
    AA463493, AY358972, BG772477, BP252919
    Consensus CDS
    CCDS2833.1
    UniProtKB/Swiss-Prot
    Q9Y6I9
    Related
    ENSP00000408186.1, ENST00000457573.5
    Conserved Domains (1) summary
    cl01368
    Location:41 → 112
    GyrI-like; GyrI-like small molecule binding domain

  2. NM_001243725.2 → NP_001230654.1  testis-expressed protein 264 isoform 1

    See identical proteins and their annotated locations for NP_001230654.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 4, 5, and 7 encode the same isoform (1).
    Source sequence(s)
    AC099050, AY358972, BC008742
    Consensus CDS
    CCDS2833.1
    UniProtKB/Swiss-Prot
    Q9Y6I9
    Related
    ENSP00000378497.1, ENST00000395057.5
    Conserved Domains (1) summary
    cl01368
    Location:41 → 112
    GyrI-like; GyrI-like small molecule binding domain

  3. NM_001243726.2 → NP_001230655.1  testis-expressed protein 264 isoform 1

    See identical proteins and their annotated locations for NP_001230655.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 4, 5, and 7 encode the same isoform (1).
    Source sequence(s)
    AC099050, AY358972, BC001592, BC008742
    Consensus CDS
    CCDS2833.1
    UniProtKB/Swiss-Prot
    Q9Y6I9
    Related
    ENSP00000398802.1, ENST00000416589.5
    Conserved Domains (1) summary
    cl01368
    Location:41 → 112
    GyrI-like; GyrI-like small molecule binding domain

  4. NM_001243727.2 → NP_001230656.1  testis-expressed protein 264 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and lacks an exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AA463493, AY358972, BG772477, HY149215
    Consensus CDS
    CCDS74945.1
    UniProtKB/Swiss-Prot
    Q9Y6I9
    UniProtKB/TrEMBL
    A0A087WTU3
    Related
    ENSP00000478139.1, ENST00000614067.4

  5. NM_001278195.1 → NP_001265124.1  testis-expressed protein 264 isoform 1

    See identical proteins and their annotated locations for NP_001265124.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 4, 5, and 7 encode the same isoform (1).
    Source sequence(s)
    AA463493, AY358972, BG772477, BI826172
    Consensus CDS
    CCDS2833.1
    UniProtKB/Swiss-Prot
    Q9Y6I9
    Related
    ENSP00000477946.1, ENST00000611400.4
    Conserved Domains (1) summary
    cl01368
    Location:41 → 112
    GyrI-like; GyrI-like small molecule binding domain

  6. NM_015926.6 → NP_057010.1  testis-expressed protein 264 isoform 1

    See identical proteins and their annotated locations for NP_057010.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1, 2, 4, 5, and 7 encode the same isoform.
    Source sequence(s)
    AA463493, AY358972, BG772477
    Consensus CDS
    CCDS2833.1
    UniProtKB/Swiss-Prot
    Q9Y6I9
    Related
    ENSP00000340969.5, ENST00000341333.9
    Conserved Domains (1) summary
    cl01368
    Location:41 → 112
    GyrI-like; GyrI-like small molecule binding domain

RNA

  1. NR_024012.3 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an exon, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AA463493, AY358972, BG772477

  2. NR_103462.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) uses an alternate 5'-terminal exon and lacks an internal exon, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AA463493, AY358972, CB142778

  3. NR_103463.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) uses an alternate 5'-terminal exon and lacks an internal exon, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AA463493, AY358972, CB142778

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    51671175..51704323
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011533805.2 → XP_011532107.1  testis-expressed protein 264 isoform X2

    See identical proteins and their annotated locations for XP_011532107.1

    UniProtKB/Swiss-Prot
    Q9Y6I9
    Related
    ENSP00000396628.1, ENST00000415259.5
    Conserved Domains (1) summary
    cl01368
    Location:41 → 112
    GyrI-like; GyrI-like small molecule binding domain

  2. XM_017006574.2 → XP_016862063.1  testis-expressed protein 264 isoform X4

  3. XM_006713197.4 → XP_006713260.1  testis-expressed protein 264 isoform X2

    See identical proteins and their annotated locations for XP_006713260.1

    UniProtKB/Swiss-Prot
    Q9Y6I9
    Conserved Domains (1) summary
    cl01368
    Location:41 → 112
    GyrI-like; GyrI-like small molecule binding domain

  4. XM_006713195.3 → XP_006713258.1  testis-expressed protein 264 isoform X2

    See identical proteins and their annotated locations for XP_006713258.1

    UniProtKB/Swiss-Prot
    Q9Y6I9
    Conserved Domains (1) summary
    cl01368
    Location:41 → 112
    GyrI-like; GyrI-like small molecule binding domain

  5. XM_006713198.2 → XP_006713261.1  testis-expressed protein 264 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y6I9.1 GenPept UniProtKB/Swiss-Prot:Q9Y6I9

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