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CHST15 carbohydrate sulfotransferase 15 [ Homo sapiens (human) ]

Gene ID: 51363, updated on 11-Sep-2019

Summary

Official Symbol
CHST15provided by HGNC
Official Full Name
carbohydrate sulfotransferase 15provided by HGNC
Primary source
HGNC:HGNC:18137
See related
Ensembl:ENSG00000182022 MIM:608277
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BRAG; GALNAC4S-6ST
Summary
Chondroitin sulfate (CS) is a glycosaminoglycan which is an important structural component of the extracellular matrix and which links to proteins to form proteoglycans. Chondroitin sulfate E (CS-E) is an isomer of chondroitin sulfate in which the C-4 and C-6 hydroxyl groups are sulfated. This gene encodes a type II transmembrane glycoprotein that acts as a sulfotransferase to transfer sulfate to the C-6 hydroxal group of chondroitin sulfate. This gene has also been identified as being co-expressed with RAG1 in B-cells and as potentially acting as a B-cell surface signaling receptor. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012]
Expression
Ubiquitous expression in ovary (RPKM 9.9), spleen (RPKM 9.5) and 25 other tissues See more
Orthologs

Genomic context

See CHST15 in Genome Data Viewer
Location:
10q26.13
Exon count:
16
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (124006059..124093684, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (125765669..125853200, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984128 Neighboring gene uncharacterized LOC107984276 Neighboring gene Y-box binding protein 2 pseudogene 1 Neighboring gene uncharacterized LOC105378536 Neighboring gene uncharacterized LOC107984184

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ60141, KIAA0598, MGC34346, DKFZp781H1369

Gene Ontology Provided by GOA

Process Evidence Code Pubs
chondroitin sulfate biosynthetic process TAS
Traceable Author Statement
more info
 
hexose biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
Golgi membrane TAS
Traceable Author Statement
more info
 
integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
carbohydrate sulfotransferase 15
Names
B cell RAG associated protein (GALNAC4S-6ST)
B-cell RAG-associated gene protein
carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
hBRAG
NP_001257693.1
NP_001257694.1
NP_055678.2
NP_056976.2
XP_005269948.1
XP_005269949.1
XP_005269950.1
XP_005269951.1
XP_006717954.1
XP_011538159.1
XP_016871808.1
XP_016871809.1
XP_016871810.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032891.1 RefSeqGene

    Range
    5010..90940
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001270764.2NP_001257693.1  carbohydrate sulfotransferase 15 isoform 1

    See identical proteins and their annotated locations for NP_001257693.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1, and encodes isoform (1). Variants 1 and 3 encode the same protein.
    Source sequence(s)
    AF026477, BC027908, BC075813, CR749804
    Consensus CDS
    CCDS7638.1
    UniProtKB/Swiss-Prot
    Q7LFX5
    Related
    ENSP00000402394.1, ENST00000435907.6
    Conserved Domains (1) summary
    cl21551
    Location:253505
    Sulfotransfer_3; Sulfotransferase family
  2. NM_001270765.2NP_001257694.1  carbohydrate sulfotransferase 15 isoform 2

    See identical proteins and their annotated locations for NP_001257694.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, 3' UTR, and 3' coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1. Variants 2 and 4 encode the same protein.
    Source sequence(s)
    AL683842, BC050540, BM977716
    Consensus CDS
    CCDS55731.1
    UniProtKB/Swiss-Prot
    Q7LFX5
    Conserved Domains (1) summary
    cl21551
    Location:256407
    Sulfotransfer_3; Sulfotransferase family
  3. NM_014863.4NP_055678.2  carbohydrate sulfotransferase 15 isoform 2

    See identical proteins and their annotated locations for NP_055678.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1. Variants 2 and 4 encode the same protein.
    Source sequence(s)
    AK294961, AL683842, BM977716
    Consensus CDS
    CCDS55731.1
    UniProtKB/TrEMBL
    B4DH74
    Related
    ENSP00000485905.1, ENST00000628426.1
    Conserved Domains (1) summary
    cl21551
    Location:256407
    Sulfotransfer_3; Sulfotransferase family
  4. NM_015892.5NP_056976.2  carbohydrate sulfotransferase 15 isoform 1

    See identical proteins and their annotated locations for NP_056976.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1 and 3 encode the same protein.
    Source sequence(s)
    AF026477, BC027908, BC075813, BM193389
    Consensus CDS
    CCDS7638.1
    UniProtKB/Swiss-Prot
    Q7LFX5
    Related
    ENSP00000333947.6, ENST00000346248.7
    Conserved Domains (1) summary
    cl21551
    Location:253505
    Sulfotransfer_3; Sulfotransferase family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    124006059..124093684 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005269894.5XP_005269951.1  carbohydrate sulfotransferase 15 isoform X4

    Conserved Domains (1) summary
    cl21551
    Location:253500
    Sulfotransfer_1; Sulfotransferase domain
  2. XM_006717891.4XP_006717954.1  carbohydrate sulfotransferase 15 isoform X1

    See identical proteins and their annotated locations for XP_006717954.1

    UniProtKB/Swiss-Prot
    Q7LFX5
    Conserved Domains (1) summary
    cl21551
    Location:253505
    Sulfotransfer_3; Sulfotransferase family
  3. XM_017016319.1XP_016871808.1  carbohydrate sulfotransferase 15 isoform X1

    UniProtKB/Swiss-Prot
    Q7LFX5
    Conserved Domains (1) summary
    cl21551
    Location:253505
    Sulfotransfer_3; Sulfotransferase family
  4. XM_005269891.3XP_005269948.1  carbohydrate sulfotransferase 15 isoform X1

    See identical proteins and their annotated locations for XP_005269948.1

    UniProtKB/Swiss-Prot
    Q7LFX5
    Conserved Domains (1) summary
    cl21551
    Location:253505
    Sulfotransfer_3; Sulfotransferase family
  5. XM_005269892.4XP_005269949.1  carbohydrate sulfotransferase 15 isoform X2

    Conserved Domains (1) summary
    cl21551
    Location:253498
    Sulfotransfer_1; Sulfotransferase domain
  6. XM_017016320.1XP_016871809.1  carbohydrate sulfotransferase 15 isoform X2

    Conserved Domains (1) summary
    cl21551
    Location:253498
    Sulfotransfer_1; Sulfotransferase domain
  7. XM_005269893.3XP_005269950.1  carbohydrate sulfotransferase 15 isoform X3

    Conserved Domains (1) summary
    cl21551
    Location:253498
    Sulfotransfer_1; Sulfotransferase domain
  8. XM_017016321.1XP_016871810.1  carbohydrate sulfotransferase 15 isoform X3

    Conserved Domains (1) summary
    cl21551
    Location:253498
    Sulfotransfer_1; Sulfotransferase domain
  9. XM_011539857.1XP_011538159.1  carbohydrate sulfotransferase 15 isoform X5

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