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WT1-AS WT1 antisense RNA [ Homo sapiens (human) ]

Gene ID: 51352, updated on 26-Jul-2021

Summary

Official Symbol
WT1-ASprovided by HGNC
Official Full Name
WT1 antisense RNAprovided by HGNC
Primary source
HGNC:HGNC:18135
See related
Ensembl:ENSG00000183242 MIM:607899
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
WIT1; WIT-1; WT1AS; WT1-AS1
Summary
This gene is located upstream of the Wilms tumor 1 (WT1) gene; these two genes are bi-directionally transcribed from the same promoter region. This gene is imprinted in kidney, with preferential expression from the paternal allele. Imprinting defects at chromosome 11p13 may contribute to tumorigenesis. [provided by RefSeq, May 2014]
Expression
Biased expression in ovary (RPKM 4.7), endometrium (RPKM 3.7) and 3 other tissues See more
Orthologs
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Genomic context

See WT1-AS in Genome Data Viewer
Location:
11p13
Exon count:
8
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (32435518..32458769)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (32457064..32480315)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene WT1 3' enhancer Neighboring gene WT1 transcription factor Neighboring gene WT1 intron 3 regulatory region Neighboring gene WT1/WT1-AS bi-directional promoter region Neighboring gene protein GVQW2-like Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene 9 Neighboring gene eukaryotic translation initiation factor 3 subunit M

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Other Names

  • WT1 antisense RNA (non-protein coding)
  • Wilms tumor associated protein
  • Wilms tumor upstream neighbor 1

Clone Names

  • MGC120207, MGC120208, MGC120209

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_023920.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an exon, contains an alternate 5' exon, and differs in the 3' exon, resulting in a shorter transcript, compared to variant 1.
    Source sequence(s)
    AL049692, DA743604, DB262871, DQ289488
  2. NR_120546.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript.
    Source sequence(s)
    DQ289489, DQ289490
  3. NR_120547.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon and contains two alternate 5' exons, resulting in a shorter transcript, compared to variant 1.
    Source sequence(s)
    AL049692
  4. NR_120548.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) shares no exons with variant 1, but contains the same 5' exon as variant 2 and four alternate 3' exons. The transcript is shorter than variants 1 and 2.
    Source sequence(s)
    AL049692
    Related
    ENST00000525436.1
  5. NR_120549.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) shares no exons with variant 1, but contains the same 5' exon as variant 2 and an alternate 3' exon. The transcript is shorter than variants 1 and 2.
    Source sequence(s)
    AL049692

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    32435518..32458769
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_015855.3: Suppressed sequence

    Description
    NM_015855.3: This RefSeq was permanently suppressed because it is now thought that this gene does not encode a protein.
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