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KLRF1 killer cell lectin like receptor F1 [ Homo sapiens (human) ]

Gene ID: 51348, updated on 8-Jul-2021

Summary

Official Symbol
KLRF1provided by HGNC
Official Full Name
killer cell lectin like receptor F1provided by HGNC
Primary source
HGNC:HGNC:13342
See related
Ensembl:ENSG00000150045 MIM:605029
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NKp80; CLEC5C
Summary
KLRF1, an activating homodimeric C-type lectin-like receptor (CTLR), is expressed on nearly all natural killer (NK) cells and stimulates their cytoxicity and cytokine release (Kuttruff et al., 2009 [PubMed 18922855]).[supplied by OMIM, Oct 2009]
Expression
Biased expression in spleen (RPKM 7.2), bone marrow (RPKM 3.9) and 10 other tissues See more
Orthologs
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Genomic context

See KLRF1 in Genome Data Viewer
Location:
12p13.31
Exon count:
7
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (9800052..9845005)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (9952648..9997604)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr12.528 Neighboring gene CD69 molecule Neighboring gene GCNA pseudogene 1 Neighboring gene C-type lectin domain family 2 member B Neighboring gene C-type lectin domain family 2 member A Neighboring gene killer cell lectin like receptor F2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC119907, MGC119908, MGC119909

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables MHC class I receptor activity TAS
Traceable Author Statement
more info
PubMed 
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
located_in membrane TAS
Traceable Author Statement
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
killer cell lectin-like receptor subfamily F member 1
Names
C-type lectin domain family 5 member C
activating coreceptor NKp80
killer cell lectin-like receptor subfamily F, member 1
lectin-like receptor F1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291822.2NP_001278751.1  killer cell lectin-like receptor subfamily F member 1 isoform KLRF1-s

    See identical proteins and their annotated locations for NP_001278751.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (KLRF1-s) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (KLRF1-s) that is shorter than isoform 1.
    Source sequence(s)
    AF175207, AJ305370
    Consensus CDS
    CCDS76526.1
    UniProtKB/Swiss-Prot
    Q9NZS2
    UniProtKB/TrEMBL
    A0A0C4DFN7
    Related
    ENSP00000279545.4, ENST00000279545.7
    Conserved Domains (2) summary
    cd03593
    Location:64180
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
    PHA03097
    Location:28179
    PHA03097; C-type lectin-like protein; Provisional
  2. NM_001291823.2NP_001278752.1  killer cell lectin-like receptor subfamily F member 1 isoform KLRF1-s3

    See identical proteins and their annotated locations for NP_001278752.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (KLRF1-s3) lacks three alternate coding exons that result in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (KLRF1-s3) has a distinct C-terminus and is significantly shorter than isoform 1.
    Source sequence(s)
    AF267245, AJ305370
    Consensus CDS
    CCDS76527.1
    UniProtKB/Swiss-Prot
    Q9NZS2
    Related
    ENSP00000346919.3, ENST00000354855.7
  3. NM_001366534.1NP_001353463.1  killer cell lectin-like receptor subfamily F member 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC007068, BC096734
    Related
    ENSP00000443054.1, ENST00000537723.5
  4. NM_016523.3NP_057607.1  killer cell lectin-like receptor subfamily F member 1 isoform 1

    See identical proteins and their annotated locations for NP_057607.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AF175206, AJ305370
    Consensus CDS
    CCDS41750.1
    UniProtKB/Swiss-Prot
    Q9NZS2
    UniProtKB/TrEMBL
    A0A0C4DGY9
    Related
    ENSP00000483713.1, ENST00000617889.5
    Conserved Domains (1) summary
    cd03593
    Location:114230
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

RNA

  1. NR_120305.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (KLRF1-s2) lacks two internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF267244, AJ305370
    Related
    ENST00000612321.4
  2. NR_159359.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC007068, KF573680
  3. NR_159360.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC007068, BC098257
    Related
    ENST00000617793.4
  4. NR_159361.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC007068, BC098166

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    9800052..9845005
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017019415.1XP_016874904.1  killer cell lectin-like receptor subfamily F member 1 isoform X2

RNA

  1. XR_931301.2 RNA Sequence

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