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TAOK3 TAO kinase 3 [ Homo sapiens (human) ]

Gene ID: 51347, updated on 13-Mar-2020

Summary

Official Symbol
TAOK3provided by HGNC
Official Full Name
TAO kinase 3provided by HGNC
Primary source
HGNC:HGNC:18133
See related
Ensembl:ENSG00000135090 MIM:616711
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DPK; JIK; hKFC-A; MAP3K18
Summary
The protein encoded by this gene is a serine/threonine protein kinase that activates the p38/MAPK14 stress-activated MAPK cascade but inhibits the basal activity of the MAPK8/JNK cascade. The encoded protein is a member of the GCK subfamily of STE20-like kinases. [provided by RefSeq, Oct 2016]
Expression
Ubiquitous expression in brain (RPKM 12.0), prostate (RPKM 9.7) and 25 other tissues See more
Orthologs

Genomic context

See TAOK3 in Genome Data Viewer
Location:
12q24.23
Exon count:
26
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (118149801..118372950, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (118587606..118810750, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928274 Neighboring gene Sharpr-MPRA regulatory region 576 Neighboring gene phosphatidylethanolamine binding protein 1 Neighboring gene ribosomal protein S2 pseudogene 5 Neighboring gene SDS3 homolog, SIN3A corepressor complex component Neighboring gene Sharpr-MPRA regulatory region 1346 Neighboring gene long intergenic non-protein coding RNA 2460

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
TAOK3, a novel genome-wide association study locus associated with morphine requirement and postoperative pain in a retrospective pediatric day surgery population.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ31808, DKFZp666H245

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
MAP kinase kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase inhibitor activity TAS
Traceable Author Statement
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
DNA repair IEA
Inferred from Electronic Annotation
more info
 
G2 DNA damage checkpoint IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
activation of MAPKK activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
activation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to DNA damage stimulus IDA
Inferred from Direct Assay
more info
PubMed 
mitotic G2 DNA damage checkpoint IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of JNK cascade IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of JNK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of JUN kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of stress-activated MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signal transduction by protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
stress-activated protein kinase signaling cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase TAO3
Names
CTCL-associated antigen HD-CL-09
JNK/SAPK-inhibitory kinase
STE20-like kinase
cutaneous T-cell lymphoma-associated antigen HD-CL-09
dendritic cell-derived protein kinase
jun kinase-inhibitory kinase
kinase from chicken homolog A
thousand and one amino acid protein 3
NP_001333416.1
NP_001333417.1
NP_001333418.1
NP_001333419.1
NP_001333420.1
NP_001333421.1
NP_001333422.1
NP_001333423.1
NP_001333424.1
NP_001333425.1
NP_001333426.1
NP_057365.3
XP_005253955.1
XP_006719508.1
XP_011536739.1
XP_016874897.1
XP_016874898.1
XP_016874899.1
XP_016874901.1
XP_016874902.1
XP_024304778.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051835.1 RefSeqGene

    Range
    5039..228145
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001346487.2NP_001333416.1  serine/threonine-protein kinase TAO3 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC026366, AC026367, AC073596
    Conserved Domains (1) summary
    cd06633
    Location:2314
    STKc_TAO3; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 3
  2. NM_001346488.2NP_001333417.1  serine/threonine-protein kinase TAO3 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), as well as variants 2 and 4, encodes isoform b.
    Source sequence(s)
    AC026366, AC026367, AC073596
    Consensus CDS
    CCDS9188.1
    UniProtKB/Swiss-Prot
    Q9H2K8
  3. NM_001346489.2NP_001333418.1  serine/threonine-protein kinase TAO3 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), as well as variants 2 and 3, encodes isoform b.
    Source sequence(s)
    AC026366, AF135158, DB165555
    Consensus CDS
    CCDS9188.1
    UniProtKB/Swiss-Prot
    Q9H2K8
    Related
    ENSP00000416374.2, ENST00000419821.6
  4. NM_001346490.2NP_001333419.1  serine/threonine-protein kinase TAO3 isoform c

    Status: REVIEWED

    Source sequence(s)
    AC026366, AC026367, AC073596
    Conserved Domains (2) summary
    cl21453
    Location:1144
    PKc_like; Protein Kinases, catalytic domain
    cl26511
    Location:254720
    Neuromodulin_N; Gap junction protein N-terminal region
  5. NM_001346491.2NP_001333420.1  serine/threonine-protein kinase TAO3 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), as well as variant 7, encodes isoform d.
    Source sequence(s)
    AC026366, AC026367, AC073596
    Conserved Domains (2) summary
    cl21453
    Location:1144
    PKc_like; Protein Kinases, catalytic domain
    cl26511
    Location:245711
    Neuromodulin_N; Gap junction protein N-terminal region
  6. NM_001346492.2NP_001333421.1  serine/threonine-protein kinase TAO3 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), as well as variant 6, encodes isoform d.
    Source sequence(s)
    AC026366, AC026367, AC073596
    Conserved Domains (2) summary
    cl21453
    Location:1144
    PKc_like; Protein Kinases, catalytic domain
    cl26511
    Location:245711
    Neuromodulin_N; Gap junction protein N-terminal region
  7. NM_001346493.2NP_001333422.1  serine/threonine-protein kinase TAO3 isoform e

    Status: REVIEWED

    Source sequence(s)
    AC026366, AC026367, AC073596
  8. NM_001346494.2NP_001333423.1  serine/threonine-protein kinase TAO3 isoform f

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9), as well as variant 10, encodes isoform f.
    Source sequence(s)
    AC026366
    Consensus CDS
    CCDS86334.1
    UniProtKB/TrEMBL
    G3V1Q8
    Related
    ENSP00000443834.1, ENST00000537952.1
    Conserved Domains (1) summary
    pfam17380
    Location:162394
    DUF5401; Family of unknown function (DUF5401)
  9. NM_001346495.2NP_001333424.1  serine/threonine-protein kinase TAO3 isoform f

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10), as well as variant 9, encodes isoform f.
    Source sequence(s)
    AC026366
    Consensus CDS
    CCDS86334.1
    UniProtKB/TrEMBL
    G3V1Q8
    Conserved Domains (1) summary
    pfam17380
    Location:162394
    DUF5401; Family of unknown function (DUF5401)
  10. NM_001346496.2NP_001333425.1  serine/threonine-protein kinase TAO3 isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11), as well as variant 12, encodes isoform g.
    Source sequence(s)
    AC026366
  11. NM_001346497.2NP_001333426.1  serine/threonine-protein kinase TAO3 isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12), as well as variant 11, encodes isoform g.
    Source sequence(s)
    AC026366
  12. NM_016281.4NP_057365.3  serine/threonine-protein kinase TAO3 isoform b

    See identical proteins and their annotated locations for NP_057365.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), as well as variants 3 and 4, encodes isoform b.
    Source sequence(s)
    AA744362, AI057643, AL833460, BC002756, DB066061
    Consensus CDS
    CCDS9188.1
    UniProtKB/Swiss-Prot
    Q9H2K8
    Related
    ENSP00000376317.3, ENST00000392533.8
    Conserved Domains (2) summary
    smart00220
    Location:27277
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06633
    Location:2314
    STKc_TAO3; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 3

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    118149801..118372950 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017019408.2XP_016874897.1  serine/threonine-protein kinase TAO3 isoform X1

    Conserved Domains (1) summary
    cd06633
    Location:2314
    STKc_TAO3; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 3
  2. XM_017019413.2XP_016874902.1  serine/threonine-protein kinase TAO3 isoform X3

    Conserved Domains (2) summary
    cl21453
    Location:1144
    PKc_like; Protein Kinases, catalytic domain
    cl26511
    Location:245711
    Neuromodulin_N; Gap junction protein N-terminal region
  3. XM_017019412.2XP_016874901.1  serine/threonine-protein kinase TAO3 isoform X2

    Conserved Domains (2) summary
    cl21453
    Location:1144
    PKc_like; Protein Kinases, catalytic domain
    cl26511
    Location:254720
    Neuromodulin_N; Gap junction protein N-terminal region
  4. XM_011538437.2XP_011536739.1  serine/threonine-protein kinase TAO3 isoform X1

    See identical proteins and their annotated locations for XP_011536739.1

    Conserved Domains (1) summary
    cd06633
    Location:2314
    STKc_TAO3; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 3
  5. XM_006719445.3XP_006719508.1  serine/threonine-protein kinase TAO3 isoform X1

    See identical proteins and their annotated locations for XP_006719508.1

    Conserved Domains (1) summary
    cd06633
    Location:2314
    STKc_TAO3; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 3
  6. XM_017019410.2XP_016874899.1  serine/threonine-protein kinase TAO3 isoform X1

    Conserved Domains (1) summary
    cd06633
    Location:2314
    STKc_TAO3; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 3
  7. XM_017019409.2XP_016874898.1  serine/threonine-protein kinase TAO3 isoform X1

    Conserved Domains (1) summary
    cd06633
    Location:2314
    STKc_TAO3; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 3
  8. XM_024449010.1XP_024304778.1  serine/threonine-protein kinase TAO3 isoform X1

    Conserved Domains (1) summary
    cd06633
    Location:2314
    STKc_TAO3; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 3
  9. XM_005253898.2XP_005253955.1  serine/threonine-protein kinase TAO3 isoform X1

    See identical proteins and their annotated locations for XP_005253955.1

    Conserved Domains (1) summary
    cd06633
    Location:2314
    STKc_TAO3; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 3
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