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ZBTB7A zinc finger and BTB domain containing 7A [ Homo sapiens (human) ]

Gene ID: 51341, updated on 6-Jan-2019

Summary

Official Symbol
ZBTB7Aprovided by HGNC
Official Full Name
zinc finger and BTB domain containing 7Aprovided by HGNC
Primary source
HGNC:HGNC:18078
See related
Ensembl:ENSG00000178951 MIM:605878
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LRF; FBI1; FBI-1; TIP21; ZBTB7; ZNF857A; pokemon
Expression
Ubiquitous expression in colon (RPKM 8.0), stomach (RPKM 5.5) and 25 other tissues See more
Orthologs

Genomic context

See ZBTB7A in Genome Data Viewer
Location:
19p13.3
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (4043304..4066945, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (4045216..4066816, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, C/D box 37 Neighboring gene eukaryotic translation elongation factor 2 Neighboring gene protein inhibitor of activated STAT 4 Neighboring gene mitogen-activated protein kinase kinase 2 Neighboring gene cAMP responsive element binding protein 3 like 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Binding of FBI-1 to HIV-1 Tat is mediated by the zinc finger (ZF) domain of FBI-1 (amino acids 377-584) and is diminished by point mutations in Tat at amino acids 18, 30, and 31 PubMed
tat FBI-1 is a cellular POZ-domain-containing protein that binds to the HIV-1 LTR and Tat protein and specifically stimulates Tat activity PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC99631, DKFZp547O146

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific NAS
Non-traceable Author Statement
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SMAD binding IDA
Inferred from Direct Assay
more info
PubMed 
SMAD binding IPI
Inferred from Physical Interaction
more info
PubMed 
activating transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
androgen receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
androgen receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
histone acetyltransferase binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription corepressor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription corepressor binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription corepressor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
B cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to DNA damage stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chromatin organization ISS
Inferred from Sequence or Structural Similarity
more info
 
chromatin remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
double-strand break repair via classical nonhomologous end joining ISS
Inferred from Sequence or Structural Similarity
more info
 
erythrocyte maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
erythrocyte maturation ISS
Inferred from Sequence or Structural Similarity
more info
 
fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of Notch signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of androgen receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of transforming growth factor beta receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of NF-kappaB transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
protein localization to nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of alternative mRNA splicing, via spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of glycolytic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription regulatory region DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with DNA-dependent protein kinase complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
colocalizes_with DNA-dependent protein kinase complex ISS
Inferred from Sequence or Structural Similarity
more info
 
colocalizes_with NuRD complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with site of double-strand break ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
zinc finger and BTB domain-containing protein 7A
Names
HIV-1 1st-binding protein 1
HIV-1 inducer of short transcripts binding protein
POK erythroid myeloid ontogenic factor
POZ and Krueppel erythroid myeloid ontogenic factor
TTF-I-interacting peptide 21
factor binding IST protein 1
factor that binds to inducer of short transcripts protein 1
leukemia/lymphoma-related factor
lymphoma related factor
pokemon 1
zinc finger and BTB domain containing 7A, HIV-1 inducer of short transcripts binding protein
zinc finger protein 857A

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317990.1NP_001304919.1  zinc finger and BTB domain-containing protein 7A

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC016586, BC084568, DB495635
    Consensus CDS
    CCDS12119.1
    UniProtKB/Swiss-Prot
    O95365
    Related
    ENSP00000471865.1, ENST00000601588.1
    Conserved Domains (3) summary
    sd00017
    Location:412432
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:24131
    BTB; BTB/POZ domain
    pfam13465
    Location:425449
    zf-H2C2_2; Zinc-finger double domain
  2. NM_015898.4NP_056982.1  zinc finger and BTB domain-containing protein 7A

    See identical proteins and their annotated locations for NP_056982.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC016586, BC084568
    Consensus CDS
    CCDS12119.1
    UniProtKB/Swiss-Prot
    O95365
    Related
    ENSP00000323670.3, ENST00000322357.8
    Conserved Domains (3) summary
    sd00017
    Location:412432
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:24131
    BTB; BTB/POZ domain
    pfam13465
    Location:425449
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    4043304..4066945 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005259571.4XP_005259628.1  zinc finger and BTB domain-containing protein 7A isoform X2

    See identical proteins and their annotated locations for XP_005259628.1

    UniProtKB/Swiss-Prot
    O95365
    Conserved Domains (3) summary
    sd00017
    Location:412432
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:24131
    BTB; BTB/POZ domain
    pfam13465
    Location:425449
    zf-H2C2_2; Zinc-finger double domain
  2. XM_005259570.5XP_005259627.3  zinc finger and BTB domain-containing protein 7A isoform X1

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