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ZBTB7A zinc finger and BTB domain containing 7A [ Homo sapiens (human) ]

Gene ID: 51341, updated on 23-Nov-2021

Summary

Official Symbol
ZBTB7Aprovided by HGNC
Official Full Name
zinc finger and BTB domain containing 7Aprovided by HGNC
Primary source
HGNC:HGNC:18078
See related
Ensembl:ENSG00000178951 MIM:605878
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LRF; FBI1; FBI-1; TIP21; ZBTB7; ZNF857A; pokemon
Expression
Ubiquitous expression in colon (RPKM 8.0), stomach (RPKM 5.5) and 25 other tissues See more
Orthologs
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Genomic context

See ZBTB7A in Genome Data Viewer
Location:
19p13.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (4043303..4066899, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (4043301..4066897, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene eukaryotic translation elongation factor 2 Neighboring gene small nucleolar RNA, C/D box 37 Neighboring gene protein inhibitor of activated STAT 4 Neighboring gene mitogen-activated protein kinase kinase 2 Neighboring gene Sharpr-MPRA regulatory region 2607

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Binding of FBI-1 to HIV-1 Tat is mediated by the zinc finger (ZF) domain of FBI-1 (amino acids 377-584) and is diminished by point mutations in Tat at amino acids 18, 30, and 31 PubMed
tat FBI-1 is a cellular POZ-domain-containing protein that binds to the HIV-1 LTR and Tat protein and specifically stimulates Tat activity PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC99631, DKFZp547O146

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables SMAD binding IDA
Inferred from Direct Assay
more info
PubMed 
enables SMAD binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables androgen receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables androgen receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables histone acetyltransferase binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription corepressor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription corepressor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in B cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in chromatin organization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in chromatin remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in double-strand break repair via classical nonhomologous end joining ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in erythrocyte maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in erythrocyte maturation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of Notch signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of androgen receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in negative regulation of transforming growth factor beta receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of NF-kappaB transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein localization to nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of alternative mRNA splicing, via spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of glycolytic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription regulatory region DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with site of double-strand break ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
zinc finger and BTB domain-containing protein 7A
Names
HIV-1 1st-binding protein 1
HIV-1 inducer of short transcripts binding protein
POK erythroid myeloid ontogenic factor
POZ and Krueppel erythroid myeloid ontogenic factor
TTF-I-interacting peptide 21
factor binding IST protein 1
factor that binds to inducer of short transcripts protein 1
leukemia/lymphoma-related factor
lymphoma related factor
pokemon 1
zinc finger and BTB domain containing 7A, HIV-1 inducer of short transcripts binding protein
zinc finger protein 857A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317990.2NP_001304919.1  zinc finger and BTB domain-containing protein 7A

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC016586, BC084568, DB495635
    Consensus CDS
    CCDS12119.1
    UniProtKB/Swiss-Prot
    O95365
    Related
    ENSP00000471865.1, ENST00000601588.1
    Conserved Domains (3) summary
    sd00017
    Location:412432
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18326
    Location:9128
    BTB_POZ_ZBTB7A; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A)
    pfam13465
    Location:425449
    zf-H2C2_2; Zinc-finger double domain
  2. NM_015898.4NP_056982.1  zinc finger and BTB domain-containing protein 7A

    See identical proteins and their annotated locations for NP_056982.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC016586, BC084568
    Consensus CDS
    CCDS12119.1
    UniProtKB/Swiss-Prot
    O95365
    Related
    ENSP00000323670.3, ENST00000322357.9
    Conserved Domains (3) summary
    sd00017
    Location:412432
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18326
    Location:9128
    BTB_POZ_ZBTB7A; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A)
    pfam13465
    Location:425449
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    4043303..4066899 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005259571.4XP_005259628.1  zinc finger and BTB domain-containing protein 7A isoform X2

    See identical proteins and their annotated locations for XP_005259628.1

    UniProtKB/Swiss-Prot
    O95365
    Conserved Domains (3) summary
    sd00017
    Location:412432
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18326
    Location:9128
    BTB_POZ_ZBTB7A; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A)
    pfam13465
    Location:425449
    zf-H2C2_2; Zinc-finger double domain
  2. XM_005259570.5XP_005259627.3  zinc finger and BTB domain-containing protein 7A isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_020224.1: Suppressed sequence

    Description
    NM_020224.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
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