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DACT1 dishevelled binding antagonist of beta catenin 1 [ Homo sapiens (human) ]

Gene ID: 51339, updated on 23-Nov-2021

Summary

Official Symbol
DACT1provided by HGNC
Official Full Name
dishevelled binding antagonist of beta catenin 1provided by HGNC
Primary source
HGNC:HGNC:17748
See related
Ensembl:ENSG00000165617 MIM:607861
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DPR1; TBS2; FRODO; HDPR1; DAPPER; THYEX3; DAPPER1
Summary
The protein encoded by this gene belongs to the dapper family, characterized by the presence of PDZ-binding motif at the C-terminus. It interacts with, and positively regulates dishevelled-mediated signaling pathways during development. Depletion of this mRNA from xenopus embryos resulted in loss of notochord and head structures, and mice lacking this gene died shortly after birth from severe posterior malformations. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]
Expression
Broad expression in gall bladder (RPKM 10.6), ovary (RPKM 9.1) and 22 other tissues See more
Orthologs
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Genomic context

See DACT1 in Genome Data Viewer
Location:
14q23.1
Exon count:
7
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (58634061..58648321)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (59100779..59115039)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene KIAA0586 Neighboring gene heterogeneous nuclear ribonucleoprotein C pseudogene 1 Neighboring gene ribosomal protein L9 pseudogene 5 Neighboring gene uncharacterized LOC102723725 Neighboring gene Sharpr-MPRA regulatory region 9975

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables beta-catenin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables beta-catenin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables delta-catenin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables histone deacetylase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase A binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein kinase C binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in embryonic hindgut morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of G1/S transition of mitotic cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of JNK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of JNK cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of beta-catenin-TCF complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of protein binding IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in neural tube development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cellular protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cellular protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein binding IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of Wnt signaling pathway, planar cell polarity pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of Wnt signaling pathway, planar cell polarity pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT involved_in regulation of nodal signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of protein stability IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
dapper homolog 1
Names
dapper antagonist of catenin 1
dapper, antagonist of beta-catenin, homolog 1
hepatocellular carcinoma novel gene 3 protein
heptacellular carcinoma novel gene 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032025.1 RefSeqGene

    Range
    8895..19254
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001079520.2NP_001072988.1  dapper homolog 1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame acceptor splice site at the 3' terminal exon compared to variant 1. This results in a shorter isoform (2) missing an internal protein segment compared to isoform 1.
    Source sequence(s)
    AL133312, BU742074, CN304224, DR001289, DR157190
    Consensus CDS
    CCDS41961.1
    UniProtKB/Swiss-Prot
    Q9NYF0
    Related
    ENSP00000378582.3, ENST00000395153.8
    Conserved Domains (1) summary
    pfam15268
    Location:46799
    Dapper; Dapper
  2. NM_016651.6NP_057735.2  dapper homolog 1 isoform 1

    See identical proteins and their annotated locations for NP_057735.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AL133312, BK000256, BU742074, CN304224, DR001289
    Consensus CDS
    CCDS9736.1
    UniProtKB/Swiss-Prot
    Q9NYF0
    Related
    ENSP00000337439.4, ENST00000335867.4
    Conserved Domains (1) summary
    pfam15268
    Location:46836
    Dapper; Dapper

RNA

  1. NR_046093.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate 5' terminal exon, and uses an alternate acceptor splice site at the 3' terminal exon compared to variant 1. It is represented as non-coding due to the presence of an upstream ORF (with a strong Kozak signal) that is predicted to interfere with the translation of the longest downstream ORF; translation of the upstream ORF renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF251079, AK316237, AL133312
  2. NR_046095.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AF251079, AK299879, AK316164
  3. NR_165650.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL133312
  4. NR_165651.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL133312
  5. NR_165652.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL133312

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    58634061..58648321
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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