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THEM6 thioesterase superfamily member 6 [ Homo sapiens (human) ]

Gene ID: 51337, updated on 4-Jul-2021

Summary

Official Symbol
THEM6provided by HGNC
Official Full Name
thioesterase superfamily member 6provided by HGNC
Primary source
HGNC:HGNC:29656
See related
Ensembl:ENSG00000130193
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DSCD75; C8orf55
Expression
Ubiquitous expression in kidney (RPKM 10.3), thyroid (RPKM 7.0) and 25 other tissues See more
Orthologs
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Genomic context

See THEM6 in Genome Data Viewer
Location:
8q24.3
Exon count:
3
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (142727223..142736927)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (143808641..143818345)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene prostate stem cell antigen Neighboring gene lymphocyte antigen 6 family member K Neighboring gene lncRNA associated with ovarian cancer 1 Neighboring gene secreted LY6/PLAUR domain containing 1 Neighboring gene LY6/PLAUR domain containing 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of thioesterase superfamily member 6 (THEM6) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein THEM6
Names
UPF0670 protein C8orf55
UPF0670 protein THEM6
mesenchymal stem cell protein DSCD75

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363000.2NP_001349929.1  protein THEM6 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AF242773, AK301564, BC001311
    Conserved Domains (1) summary
    pfam13279
    Location:54120
    4HBT_2; Thioesterase-like superfamily
  2. NM_016647.3NP_057731.1  protein THEM6 isoform 1

    See identical proteins and their annotated locations for NP_057731.1

    Status: VALIDATED

    Source sequence(s)
    AF242773, BC001311
    Consensus CDS
    CCDS6386.1
    UniProtKB/Swiss-Prot
    Q8WUY1
    Related
    ENSP00000338607.3, ENST00000336138.4
    Conserved Domains (1) summary
    pfam13279
    Location:54185
    4HBT_2; Thioesterase-like superfamily

RNA

  1. NR_156431.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC108002, AF242773, BC001311

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    142727223..142736927
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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