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TNFRSF12A TNF receptor superfamily member 12A [ Homo sapiens (human) ]

Gene ID: 51330, updated on 15-Jan-2022

Summary

Official Symbol
TNFRSF12Aprovided by HGNC
Official Full Name
TNF receptor superfamily member 12Aprovided by HGNC
Primary source
HGNC:HGNC:18152
See related
Ensembl:ENSG00000006327 MIM:605914
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FN14; CD266; TWEAKR
Summary
Involved in positive regulation of extrinsic apoptotic signaling pathway and regulation of wound healing. Predicted to be located in cell surface and ruffle. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Ubiquitous expression in gall bladder (RPKM 21.3), liver (RPKM 18.8) and 23 other tissues See more
Orthologs
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Genomic context

See TNFRSF12A in Genome Data Viewer
Location:
16p13.3
Exon count:
4
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (3020368..3022383)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (3070369..3072384)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene claudin 9 Neighboring gene claudin 6 Neighboring gene host cell factor C1 regulator 1 Neighboring gene THO complex 6 Neighboring gene BICD family like cargo adaptor 2 Neighboring gene uncharacterized LOC100128770

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in angiogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of extrinsic apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of extrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of wound healing IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
tumor necrosis factor receptor superfamily member 12A
Names
FGF-inducible 14
fibroblast growth factor-inducible immediate-early response protein 14
tweak-receptor
type I transmembrane protein Fn14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016639.3NP_057723.1  tumor necrosis factor receptor superfamily member 12A precursor

    See identical proteins and their annotated locations for NP_057723.1

    Status: VALIDATED

    Source sequence(s)
    BC002718
    Consensus CDS
    CCDS10489.1
    UniProtKB/Swiss-Prot
    Q9NP84
    Related
    ENSP00000326737.5, ENST00000326577.9
    Conserved Domains (2) summary
    cd13413
    Location:36104
    TNFRSF12A; CRD2 [structural motif]
    pfam12191
    Location:23129
    stn_TNFRSF12A; tumor necrosis factor receptor stn_TNFRSF12A_TNFR domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    3020368..3022383
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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