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ARL6IP4 ADP ribosylation factor like GTPase 6 interacting protein 4 [ Homo sapiens (human) ]

Gene ID: 51329, updated on 4-Nov-2018

Summary

Official Symbol
ARL6IP4provided by HGNC
Official Full Name
ADP ribosylation factor like GTPase 6 interacting protein 4provided by HGNC
Primary source
HGNC:HGNC:18076
See related
Ensembl:ENSG00000182196 MIM:607668; Vega:OTTHUMG00000168779
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SR-25; SRp25; SFRS20; SRrp37
Expression
Ubiquitous expression in fat (RPKM 37.6), kidney (RPKM 36.8) and 25 other tissues See more
Orthologs

Genomic context

See ARL6IP4 in Genome Data Viewer
Location:
12q24.31
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (122980060..122982913)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (123464607..123467460)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene VPS37B, ESCRT-I subunit Neighboring gene ATP binding cassette subfamily B member 9 Neighboring gene 2-oxoglutarate and iron dependent oxygenase domain containing 2 Neighboring gene phosphatidylinositol transfer protein membrane associated 2 Neighboring gene microRNA 4304 Neighboring gene PITPNM2 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Phenotypes

NHGRI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci.
NHGRI GWA Catalog
Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: OGFOD2

Homology

Clone Names

  • MGC814

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
RNA splicing IEA
Inferred from Electronic Annotation
more info
 
mRNA processing IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nuclear speck IEA
Inferred from Electronic Annotation
more info
 
nucleolus IEA
Inferred from Electronic Annotation
more info
 
nucleus TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
ADP-ribosylation factor-like protein 6-interacting protein 4
Names
ADP-ribosylation factor GTPase 6 interacting protein 4
ADP-ribosylation factor-like 6 interacting protein 4
ADP-ribosylation-like factor 6 interacting protein 4
ARL-6-interacting protein 4
HSP-975
HSVI binding protein
SR-15
SRp25 nuclear protein
aip-4
splicing factor SRrp37
splicing factor, arginine/serine-rich 20
splicing regulator SRrp38

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002251.2NP_001002251.2  ADP-ribosylation factor-like protein 6-interacting protein 4 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an alternate splice site in the coding region, but maintains the reading frame, compared to variant 1. The resulting isoform (3) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AA887283, BC015909, BC094839
    Consensus CDS
    CCDS45004.2
    UniProtKB/Swiss-Prot
    Q66PJ3
    Related
    ENSP00000414847.3, OTTHUMP00000239439, ENST00000453766.6, OTTHUMT00000401037
    Conserved Domains (1) summary
    pfam10500
    Location:215411
    SR-25; Nuclear RNA-splicing-associated protein
  2. NM_001002252.2NP_001002252.2  ADP-ribosylation factor-like protein 6-interacting protein 4 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has an alternate splice junction in the central region and an additional segment in the 3' region, compared to variant 1. The resulting isoform (4) lacks an internal segment and has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AA887283, BC015569, BC015909
    Consensus CDS
    CCDS41856.2
    UniProtKB/Swiss-Prot
    Q66PJ3
    Related
    ENSP00000376230.3, OTTHUMP00000239436, ENST00000392435.6, OTTHUMT00000401034
    Conserved Domains (1) summary
    pfam10500
    Location:215384
    SR-25; Nuclear RNA-splicing-associated protein
  3. NM_001278378.1NP_001265307.1  ADP-ribosylation factor-like protein 6-interacting protein 4 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) has multiple differences in the coding region, compared to variant 1. The resulting isoform (5) lacks two internal segments, compared to isoform 1.
    Source sequence(s)
    AA887283, BC001958, BC015909, CD672894, DQ099385
    UniProtKB/Swiss-Prot
    Q66PJ3
    Conserved Domains (1) summary
    pfam10500
    Location:215363
    SR-25; Nuclear RNA-splicing-associated protein
  4. NM_001278379.1NP_001265308.1  ADP-ribosylation factor-like protein 6-interacting protein 4 isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) has multiple differences in the coding region, compared to variant 1. The resulting isoform (6) lacks two internal segments, compared to isoform 1.
    Source sequence(s)
    AA887283, BC015909, BQ643520
    UniProtKB/Swiss-Prot
    Q66PJ3
    Conserved Domains (1) summary
    pfam10500
    Location:95280
    SR-25; Nuclear RNA-splicing-associated protein
  5. NM_001278380.1NP_001265309.1  ADP-ribosylation factor-like protein 6-interacting protein 4 isoform 7

    See identical proteins and their annotated locations for NP_001265309.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) has two alternate splice sites, one of which results in a downstream start codon, compared to variant 1. The resulting isoform (7) has a shorter N-terminus and lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AA887283, BC015909, EU624491
    Consensus CDS
    CCDS61273.1
    UniProtKB/Swiss-Prot
    Q66PJ3
    Related
    ENSP00000396723.2, OTTHUMP00000239440, ENST00000454885.6, OTTHUMT00000401038
    Conserved Domains (1) summary
    pfam10500
    Location:31224
    SR-25; Nuclear RNA-splicing-associated protein
  6. NM_016638.3NP_057722.3  ADP-ribosylation factor-like protein 6-interacting protein 4 isoform 2

    See identical proteins and their annotated locations for NP_057722.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate splice junction in the coding region, but maintains the reading frame, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AA887283, EU624490
    Consensus CDS
    CCDS53843.2
    UniProtKB/Swiss-Prot
    Q66PJ3
    Related
    ENSP00000442718.2, OTTHUMP00000239432, ENST00000543566.5, OTTHUMT00000401030
    Conserved Domains (1) summary
    pfam10500
    Location:215400
    SR-25; Nuclear RNA-splicing-associated protein
  7. NM_018694.3NP_061164.3  ADP-ribosylation factor-like protein 6-interacting protein 4 isoform 1

    See identical proteins and their annotated locations for NP_061164.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AA887283, BC015909
    Consensus CDS
    CCDS31923.2
    UniProtKB/Swiss-Prot
    Q66PJ3
    Related
    ENSP00000313422.6, OTTHUMP00000239433, ENST00000315580.9, OTTHUMT00000401031
    Conserved Domains (1) summary
    pfam10500
    Location:215419
    SR-25; Nuclear RNA-splicing-associated protein

RNA

  1. NR_103512.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) has three alternate splice sites in the central region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA887283, AF267748, BC015909, BC094839
    Related
    ENST00000539770.5, OTTHUMT00000401032

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p12 Primary Assembly

    Range
    122980060..122982913
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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