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ARL6IP4 ADP ribosylation factor like GTPase 6 interacting protein 4 [ Homo sapiens (human) ]

Gene ID: 51329, updated on 23-Nov-2021

Summary

Official Symbol
ARL6IP4provided by HGNC
Official Full Name
ADP ribosylation factor like GTPase 6 interacting protein 4provided by HGNC
Primary source
HGNC:HGNC:18076
See related
Ensembl:ENSG00000182196 MIM:607668
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SR-25; SRp25; SFRS20; SRrp37
Expression
Ubiquitous expression in fat (RPKM 37.6), kidney (RPKM 36.8) and 25 other tissues See more
Orthologs
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Genomic context

See ARL6IP4 in Genome Data Viewer
Location:
12q24.31
Exon count:
8
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (122980233..122982909)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (123464780..123467456)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 12402 Neighboring gene VPS37B subunit of ESCRT-I Neighboring gene ATP binding cassette subfamily B member 9 Neighboring gene 2-oxoglutarate and iron dependent oxygenase domain containing 2 Neighboring gene phosphatidylinositol transfer protein membrane associated 2 Neighboring gene microRNA 4304 Neighboring gene PITPNM2 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Biological insights from 108 schizophrenia-associated genetic loci.
GeneReviews: Not available
Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: OGFOD2

Homology

Clone Names

  • MGC814

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
ADP-ribosylation factor-like protein 6-interacting protein 4
Names
ADP-ribosylation factor GTPase 6 interacting protein 4
ADP-ribosylation factor-like 6 interacting protein 4
ADP-ribosylation-like factor 6 interacting protein 4
ARL-6-interacting protein 4
HSP-975
HSVI binding protein
SR-15
SRp25 nuclear protein
aip-4
splicing factor SRrp37
splicing factor, arginine/serine-rich 20
splicing regulator SRrp38

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002251.3NP_001002251.3  ADP-ribosylation factor-like protein 6-interacting protein 4 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an alternate splice site in the coding region, but maintains the reading frame, compared to variant 1. The resulting isoform (3) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AC026362
    Consensus CDS
    CCDS45004.2
    Related
    ENSP00000414847.4, ENST00000453766.7
    Conserved Domains (1) summary
    pfam10500
    Location:31227
    SR-25; Nuclear RNA-splicing-associated protein
  2. NM_001278378.2NP_001265307.2  ADP-ribosylation factor-like protein 6-interacting protein 4 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) has multiple differences in the coding region, compared to variant 1. The resulting isoform (5) lacks two internal segments, compared to isoform 1.
    Source sequence(s)
    AC026362
    Related
    ENSP00000350532.4, ENST00000357866.4
    Conserved Domains (1) summary
    pfam10500
    Location:31179
    SR-25; Nuclear RNA-splicing-associated protein
  3. NM_001278379.2NP_001265308.2  ADP-ribosylation factor-like protein 6-interacting protein 4 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) has multiple differences in the coding region, compared to variant 1. The resulting isoform (6) lacks two internal segments, compared to isoform 1. Variants 2 and 6 both encode the same isoform (2).
    Source sequence(s)
    AC026362
    Related
    ENSP00000406036.2, ENST00000426960.6
    Conserved Domains (1) summary
    pfam10500
    Location:31216
    SR-25; Nuclear RNA-splicing-associated protein
  4. NM_001278380.2NP_001265309.1  ADP-ribosylation factor-like protein 6-interacting protein 4 isoform 7

    See identical proteins and their annotated locations for NP_001265309.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) uses an alternate splice site compared to variant 1. The resulting isoform (7) lacks an alternate internal segment compared to isoform 1.
    Source sequence(s)
    AC026362
    Consensus CDS
    CCDS61273.1
    UniProtKB/Swiss-Prot
    Q66PJ3
    Related
    ENSP00000396723.2, ENST00000454885.6
    Conserved Domains (1) summary
    pfam10500
    Location:31224
    SR-25; Nuclear RNA-splicing-associated protein
  5. NM_016638.4NP_057722.4  ADP-ribosylation factor-like protein 6-interacting protein 4 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate splice junction in the coding region, but maintains the reading frame, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1. Variants 2 and 6 both encode the same isoform (2).
    Source sequence(s)
    AC026362
    Consensus CDS
    CCDS53843.2
    Related
    ENSP00000442718.3, ENST00000543566.6
    Conserved Domains (1) summary
    pfam10500
    Location:31216
    SR-25; Nuclear RNA-splicing-associated protein
  6. NM_018694.4NP_061164.4  ADP-ribosylation factor-like protein 6-interacting protein 4 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC026362
    Consensus CDS
    CCDS31923.2
    Related
    ENSP00000313422.7, ENST00000315580.10
    Conserved Domains (1) summary
    pfam10500
    Location:31235
    SR-25; Nuclear RNA-splicing-associated protein

RNA

  1. NR_103512.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) has three alternate splice sites in the central region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC026362

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    122980233..122982909
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001002252.2: Suppressed sequence

    Description
    NM_001002252.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
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