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AMZ2 archaelysin family metallopeptidase 2 [ Homo sapiens (human) ]

Gene ID: 51321, updated on 14-May-2025
Official Symbol
AMZ2provided by HGNC
Official Full Name
archaelysin family metallopeptidase 2provided by HGNC
Primary source
HGNC:HGNC:28041
See related
Ensembl:ENSG00000196704 MIM:615169; AllianceGenome:HGNC:28041
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is a zinc metalloprotease that displays some activity against angiotensin-3. The encoded protein is inhibited by the aminopeptidase inhibitor amastatin, as well as by the general inhibitors o-phenanthroline and batimastat. Defects in this gene may be associated with lung tumorigenesis. [provided by RefSeq, Oct 2016]
Expression
Broad expression in testis (RPKM 44.9), brain (RPKM 18.1) and 25 other tissues See more
Orthologs
NEW
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See AMZ2 in Genome Data Viewer
Location:
17q24.2
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (68206129..68257164)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (69082913..69133740)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (66202270..66253305)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371870 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:66165711-66166210 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12637 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12638 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12639 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:66180501-66181101 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12640 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12641 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8890 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8891 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8892 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:66196439-66197255 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8893 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8894 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8895 Neighboring gene Rho GTPase activating protein 27 pseudogene 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:66224773-66225658 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12642 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12643 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8896 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:66242704-66243250 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:66243251-66243796 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8897 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8898 Neighboring gene solute carrier family 16 member 6 Neighboring gene arylsulfatase G Neighboring gene ReSE screen-validated silencer GRCh37_chr17:66287460-66287634 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12644 Neighboring gene Sharpr-MPRA regulatory region 10227 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:66340482-66340982 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:66340983-66341483 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12645 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12646 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12647 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:66374359-66374878 Neighboring gene MPRA-validated peak2959 silencer Neighboring gene tRNA-undetermined (NNN) 5-1

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
Preferred Names
archaemetzincin-2
Names
archaemetzincins-2
archeobacterial metalloproteinase-like protein 2

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051827.1 RefSeqGene

    Range
    46915..56027
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001033569.2NP_001028741.1  archaemetzincin-2 isoform 1

    See identical proteins and their annotated locations for NP_001028741.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-5 and 7-17 all encode the same isoform (1).
    Source sequence(s)
    AC005332, BE543044, BF978559
    Consensus CDS
    CCDS11674.1
    UniProtKB/Swiss-Prot
    A6NLD9, B3KR44, Q5XKF1, Q86W34, Q9NZE2
    Related
    ENSP00000376481.2, ENST00000392720.6
    Conserved Domains (1) summary
    cd11375
    Location:89297
    Peptidase_M54; Peptidase family M54, also called archaemetzincins or archaelysins
  2. NM_001033570.2NP_001028742.1  archaemetzincin-2 isoform 1

    See identical proteins and their annotated locations for NP_001028742.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-5 and 7-17 all encode the same isoform (1).
    Source sequence(s)
    AC005332, BE543044, CN278872
    Consensus CDS
    CCDS11674.1
    UniProtKB/Swiss-Prot
    A6NLD9, B3KR44, Q5XKF1, Q86W34, Q9NZE2
    Conserved Domains (1) summary
    cd11375
    Location:89297
    Peptidase_M54; Peptidase family M54, also called archaemetzincins or archaelysins
  3. NM_001033571.1NP_001028743.1  archaemetzincin-2 isoform 1

    See identical proteins and their annotated locations for NP_001028743.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-5 and 7-17 all encode the same isoform (1).
    Source sequence(s)
    AC005332, BE543044, BF978559, BM450564
    Consensus CDS
    CCDS11674.1
    UniProtKB/Swiss-Prot
    A6NLD9, B3KR44, Q5XKF1, Q86W34, Q9NZE2
    Conserved Domains (1) summary
    cd11375
    Location:89297
    Peptidase_M54; Peptidase family M54, also called archaemetzincins or archaelysins
  4. NM_001033572.1NP_001028744.1  archaemetzincin-2 isoform 1

    See identical proteins and their annotated locations for NP_001028744.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1-5 and 7-17 all encode the same isoform (1).
    Source sequence(s)
    AC005332, BE543044, BF978559
    Consensus CDS
    CCDS11674.1
    UniProtKB/Swiss-Prot
    A6NLD9, B3KR44, Q5XKF1, Q86W34, Q9NZE2
    Related
    ENSP00000463012.1, ENST00000580753.5
    Conserved Domains (1) summary
    cd11375
    Location:89297
    Peptidase_M54; Peptidase family M54, also called archaemetzincins or archaelysins
  5. NM_001033574.2NP_001028746.1  archaemetzincin-2 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. Variants 2 and 18 both encode the same isoform (2).
    Source sequence(s)
    AC005332, AK126146, AW028610
    Consensus CDS
    CCDS32714.1
    UniProtKB/Swiss-Prot
    Q86W34
    Related
    ENSP00000352831.4, ENST00000359783.8
    Conserved Domains (1) summary
    cd11375
    Location:95239
    Peptidase_M54; Peptidase family M54, also called archaemetzincins or archaelysins
  6. NM_001289054.2NP_001275983.1  archaemetzincin-2 isoform 1

    See identical proteins and their annotated locations for NP_001275983.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Variants 1-5 and 7-17 all encode the same isoform (1).
    Source sequence(s)
    AC005332, BC050709
    Consensus CDS
    CCDS11674.1
    UniProtKB/Swiss-Prot
    A6NLD9, B3KR44, Q5XKF1, Q86W34, Q9NZE2
    Conserved Domains (1) summary
    cd11375
    Location:89297
    Peptidase_M54; Peptidase family M54, also called archaemetzincins or archaelysins
  7. NM_001289056.2NP_001275985.1  archaemetzincin-2 isoform 1

    See identical proteins and their annotated locations for NP_001275985.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 1. Variants 1-5 and 7-17 all encode the same isoform (1).
    Source sequence(s)
    AC005332, AF208856, BC050709, CN278874
    Consensus CDS
    CCDS11674.1
    UniProtKB/Swiss-Prot
    A6NLD9, B3KR44, Q5XKF1, Q86W34, Q9NZE2
    Related
    ENSP00000483162.1, ENST00000612294.4
    Conserved Domains (1) summary
    cd11375
    Location:89297
    Peptidase_M54; Peptidase family M54, also called archaemetzincins or archaelysins
  8. NM_001346471.1NP_001333400.1  archaemetzincin-2 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9), as well as variants 1-5, 7-8, and 10-17, encodes isoform 1.
    Source sequence(s)
    AC005332
    Consensus CDS
    CCDS11674.1
    UniProtKB/Swiss-Prot
    A6NLD9, B3KR44, Q5XKF1, Q86W34, Q9NZE2
    Related
    ENSP00000464635.1, ENST00000577985.5
    Conserved Domains (1) summary
    cd11375
    Location:89297
    Peptidase_M54; Peptidase family M54, also called archaemetzincins or archaelysins
  9. NM_001346472.1NP_001333401.1  archaemetzincin-2 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10), as well as variants 1-5, 7-9, and 11-17, encodes isoform 1.
    Source sequence(s)
    AC005332
    Consensus CDS
    CCDS11674.1
    UniProtKB/Swiss-Prot
    A6NLD9, B3KR44, Q5XKF1, Q86W34, Q9NZE2
    Conserved Domains (1) summary
    cd11375
    Location:89297
    Peptidase_M54; Peptidase family M54, also called archaemetzincins or archaelysins
  10. NM_001346473.1NP_001333402.1  archaemetzincin-2 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11), as well as variants 1-5, 7-10, and 12-17, encodes isoform 1.
    Source sequence(s)
    AC005332
    Consensus CDS
    CCDS11674.1
    UniProtKB/Swiss-Prot
    A6NLD9, B3KR44, Q5XKF1, Q86W34, Q9NZE2
    Related
    ENSP00000501934.1, ENST00000674770.2
    Conserved Domains (1) summary
    cd11375
    Location:89297
    Peptidase_M54; Peptidase family M54, also called archaemetzincins or archaelysins
  11. NM_001346474.2NP_001333403.1  archaemetzincin-2 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12), as well as variants 1-5, 7-11, and 13-17, encodes isoform 1.
    Source sequence(s)
    AC005332
    Consensus CDS
    CCDS11674.1
    UniProtKB/Swiss-Prot
    A6NLD9, B3KR44, Q5XKF1, Q86W34, Q9NZE2
    Conserved Domains (1) summary
    cd11375
    Location:89297
    Peptidase_M54; Peptidase family M54, also called archaemetzincins or archaelysins
  12. NM_001346475.2NP_001333404.1  archaemetzincin-2 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13), as well as variants 1-5, 7-12, and 14-17, encodes isoform 1.
    Source sequence(s)
    AC005332
    Consensus CDS
    CCDS11674.1
    UniProtKB/Swiss-Prot
    A6NLD9, B3KR44, Q5XKF1, Q86W34, Q9NZE2
    Conserved Domains (1) summary
    cd11375
    Location:89297
    Peptidase_M54; Peptidase family M54, also called archaemetzincins or archaelysins
  13. NM_001346476.2NP_001333405.1  archaemetzincin-2 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14), as well as variants 1-5, 7-13, and 15-17, encodes isoform 1.
    Source sequence(s)
    AC005332
    Consensus CDS
    CCDS11674.1
    UniProtKB/Swiss-Prot
    A6NLD9, B3KR44, Q5XKF1, Q86W34, Q9NZE2
    Conserved Domains (1) summary
    cd11375
    Location:89297
    Peptidase_M54; Peptidase family M54, also called archaemetzincins or archaelysins
  14. NM_001346477.2NP_001333406.1  archaemetzincin-2 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15), as well as variants 1-5, 7-14, and 16-17, encodes isoform 1.
    Source sequence(s)
    AC005332
    Consensus CDS
    CCDS11674.1
    UniProtKB/Swiss-Prot
    A6NLD9, B3KR44, Q5XKF1, Q86W34, Q9NZE2
    Related
    ENSP00000464133.1, ENST00000577866.5
    Conserved Domains (1) summary
    cd11375
    Location:89297
    Peptidase_M54; Peptidase family M54, also called archaemetzincins or archaelysins
  15. NM_001346478.2NP_001333407.1  archaemetzincin-2 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16), as well as variants 1-5, 7-15, and 17, encodes isoform 1.
    Source sequence(s)
    AC005332
    Consensus CDS
    CCDS11674.1
    UniProtKB/Swiss-Prot
    A6NLD9, B3KR44, Q5XKF1, Q86W34, Q9NZE2
    Conserved Domains (1) summary
    cd11375
    Location:89297
    Peptidase_M54; Peptidase family M54, also called archaemetzincins or archaelysins
  16. NM_001346479.2NP_001333408.1  archaemetzincin-2 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17), as well as variants 1-5 and 7-16, encodes isoform 1.
    Source sequence(s)
    AC005332
    Consensus CDS
    CCDS11674.1
    UniProtKB/Swiss-Prot
    A6NLD9, B3KR44, Q5XKF1, Q86W34, Q9NZE2
    Conserved Domains (1) summary
    cd11375
    Location:89297
    Peptidase_M54; Peptidase family M54, also called archaemetzincins or archaelysins
  17. NM_001346480.1NP_001333409.1  archaemetzincin-2 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (18), as well as variant 6, encodes isoform 2.
    Source sequence(s)
    AC005332
    Consensus CDS
    CCDS32714.1
    UniProtKB/Swiss-Prot
    Q86W34
  18. NM_001346481.1NP_001333410.1  archaemetzincin-2 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (19), as well as variants 20-22, encodes isoform 3.
    Source sequence(s)
    AC005332
    Conserved Domains (1) summary
    cd11375
    Location:69263
    Peptidase_M54; Peptidase family M54, also called archaemetzincins or archaelysins
  19. NM_001346482.1NP_001333411.1  archaemetzincin-2 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (20), as well as variants 19 and 21-22, encodes isoform 3.
    Source sequence(s)
    AC005332
    Conserved Domains (1) summary
    cd11375
    Location:69263
    Peptidase_M54; Peptidase family M54, also called archaemetzincins or archaelysins
  20. NM_001346483.2NP_001333412.1  archaemetzincin-2 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (21), as well as variants 19-20 and 22, encodes isoform 3.
    Source sequence(s)
    AC005332
    Conserved Domains (1) summary
    cd11375
    Location:69263
    Peptidase_M54; Peptidase family M54, also called archaemetzincins or archaelysins
  21. NM_001346484.2NP_001333413.1  archaemetzincin-2 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (22), as well as variants 19-21, encodes isoform 3.
    Source sequence(s)
    AC005332
    Conserved Domains (1) summary
    cd11375
    Location:69263
    Peptidase_M54; Peptidase family M54, also called archaemetzincins or archaelysins
  22. NM_001346485.2NP_001333414.1  archaemetzincin-2 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC005332
  23. NM_016627.5NP_057711.3  archaemetzincin-2 isoform 1

    See identical proteins and their annotated locations for NP_057711.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1-5 and 7-17 all encode the same isoform (1).
    Source sequence(s)
    AK126146, BQ432895
    Consensus CDS
    CCDS11674.1
    UniProtKB/Swiss-Prot
    A6NLD9, B3KR44, Q5XKF1, Q86W34, Q9NZE2
    Related
    ENSP00000352976.3, ENST00000359904.8
    Conserved Domains (1) summary
    cd11375
    Location:89297
    Peptidase_M54; Peptidase family M54, also called archaemetzincins or archaelysins

RNA

  1. NR_144442.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC005332
  2. NR_144443.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC005332

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    68206129..68257164
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450788.2XP_024306556.1  archaemetzincin-2 isoform X1

    UniProtKB/Swiss-Prot
    A6NLD9, B3KR44, Q5XKF1, Q86W34, Q9NZE2
    Conserved Domains (1) summary
    cd11375
    Location:89297
    Peptidase_M54; Peptidase family M54, also called archaemetzincins or archaelysins
  2. XM_047436210.1XP_047292166.1  archaemetzincin-2 isoform X1

    UniProtKB/Swiss-Prot
    A6NLD9, B3KR44, Q5XKF1, Q86W34, Q9NZE2
  3. XM_024450786.2XP_024306554.1  archaemetzincin-2 isoform X1

    UniProtKB/Swiss-Prot
    A6NLD9, B3KR44, Q5XKF1, Q86W34, Q9NZE2
    Conserved Domains (1) summary
    cd11375
    Location:89297
    Peptidase_M54; Peptidase family M54, also called archaemetzincins or archaelysins
  4. XM_024450787.2XP_024306555.1  archaemetzincin-2 isoform X1

    UniProtKB/Swiss-Prot
    A6NLD9, B3KR44, Q5XKF1, Q86W34, Q9NZE2
    Conserved Domains (1) summary
    cd11375
    Location:89297
    Peptidase_M54; Peptidase family M54, also called archaemetzincins or archaelysins
  5. XM_047436211.1XP_047292167.1  archaemetzincin-2 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    69082913..69133740
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054316368.1XP_054172343.1  archaemetzincin-2 isoform X1

  2. XM_054316369.1XP_054172344.1  archaemetzincin-2 isoform X1

  3. XM_054316370.1XP_054172345.1  archaemetzincin-2 isoform X1

  4. XM_054316371.1XP_054172346.1  archaemetzincin-2 isoform X2