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MRPL35 mitochondrial ribosomal protein L35 [ Homo sapiens (human) ]

Gene ID: 51318, updated on 16-Feb-2020

Summary

Official Symbol
MRPL35provided by HGNC
Official Full Name
mitochondrial ribosomal protein L35provided by HGNC
Primary source
HGNC:HGNC:14489
See related
Ensembl:ENSG00000132313 MIM:611841
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L35mt; MRP-L35
Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified three transcript variants. Pseudogenes corresponding to this gene are found on chromosomes 6p, 10q, and Xp. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in heart (RPKM 19.0), colon (RPKM 15.8) and 25 other tissues See more
Orthologs

Genomic context

See MRPL35 in Genome Data Viewer
Location:
2p11.2
Exon count:
6
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (86199433..86213794)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (86426478..86440913)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene pentatricopeptide repeat domain 3 Neighboring gene small nucleolar RNA, C/D box 94 Neighboring gene inner membrane mitochondrial protein Neighboring gene Sharpr-MPRA regulatory region 10968 Neighboring gene microRNA 4779 Neighboring gene receptor accessory protein 1 Neighboring gene lysine demethylase 3A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
structural constituent of ribosome NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
mitochondrial translational elongation TAS
Traceable Author Statement
more info
 
mitochondrial translational termination TAS
Traceable Author Statement
more info
 
translation NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrial large ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial ribosome NAS
Non-traceable Author Statement
more info
PubMed 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
39S ribosomal protein L35, mitochondrial
Names
mitochondrial large ribosomal subunit protein bL35m

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363782.1NP_001350711.1  39S ribosomal protein L35, mitochondrial isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has a distinct 3' coding region and 3' UTR compared to variant 1. The resulting isoform (c) has a shorter and distinct C-terminus when compared to isoform a.
    Source sequence(s)
    AC009309
    Consensus CDS
    CCDS86858.1
    Related
    ENSP00000386255.1, ENST00000409180.1
    Conserved Domains (1) summary
    pfam01632
    Location:102161
    Ribosomal_L35p; Ribosomal protein L35
  2. NM_016622.4NP_057706.2  39S ribosomal protein L35, mitochondrial isoform a

    See identical proteins and their annotated locations for NP_057706.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the predominant transcript and encodes isoform a.
    Source sequence(s)
    AC009309, AL832982, BG108475, BQ421154, BQ879834, BU195549, DA443416, DB245340, F11007, H11039
    Consensus CDS
    CCDS1988.1
    UniProtKB/Swiss-Prot
    Q9NZE8
    Related
    ENSP00000338389.4, ENST00000337109.9
    Conserved Domains (1) summary
    pfam01632
    Location:102161
    Ribosomal_L35p; Ribosomal protein L35
  3. NM_145644.2NP_663619.1  39S ribosomal protein L35, mitochondrial isoform b

    See identical proteins and their annotated locations for NP_663619.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate segment, compared to variant 1, that causes a frameshift and a shorter 3' UTR. The resulting isoform (b) has a shorter C-terminus when compared to isoform a.
    Source sequence(s)
    AK314577, AL832982, BC020651, BU195549, DA413384, F11007, H11039
    Consensus CDS
    CCDS1987.1
    UniProtKB/Swiss-Prot
    Q9NZE8
    Related
    ENSP00000254644.7, ENST00000254644.12
    Conserved Domains (1) summary
    pfam01632
    Location:102161
    Ribosomal_L35p; Ribosomal protein L35

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    86199433..86213794
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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