Format

Send to:

Choose Destination

PLAC8 placenta associated 8 [ Homo sapiens (human) ]

Gene ID: 51316, updated on 10-May-2020

Summary

Official Symbol
PLAC8provided by HGNC
Official Full Name
placenta associated 8provided by HGNC
Primary source
HGNC:HGNC:19254
See related
Ensembl:ENSG00000145287 MIM:607515
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C15; DGIC; onzin; PNAS-144
Expression
Biased expression in bone marrow (RPKM 48.1), colon (RPKM 47.5) and 10 other tissues See more
Orthologs

Genomic context

See PLAC8 in Genome Data Viewer
Location:
4q21.22
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (83090048..83114729, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (84011201..84035911, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene lin-54 DREAM MuvB core complex component Neighboring gene RNA, U6 small nuclear 615, pseudogene Neighboring gene Sharpr-MPRA regulatory region 7954 Neighboring gene COP9 signalosome subunit 4 Neighboring gene Sharpr-MPRA regulatory region 10366 Neighboring gene aminomethyltransferase pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
chromatin binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
brown fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
defense response to bacterium IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
positive regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
response to cold IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
azurophil granule lumen TAS
Traceable Author Statement
more info
 
extracellular region TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
placenta-specific gene 8 protein
Names
down-regulated in gastrointestinal cancer protein
placenta specific 8

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130715.2NP_001124187.1  placenta-specific gene 8 protein

    See identical proteins and their annotated locations for NP_001124187.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 3' UTR, compared to variant 1.
    Source sequence(s)
    AC073840, AK000140
    Consensus CDS
    CCDS3601.1
    UniProtKB/Swiss-Prot
    Q9NZF1
    UniProtKB/TrEMBL
    X2BQ60
    Related
    ENSP00000399700.2, ENST00000426923.2
    Conserved Domains (1) summary
    cl04722
    Location:24108
    PLAC8; PLAC8 family
  2. NM_001130716.2NP_001124188.1  placenta-specific gene 8 protein

    See identical proteins and their annotated locations for NP_001124188.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript.
    Source sequence(s)
    AC073840, BI824905
    Consensus CDS
    CCDS3601.1
    UniProtKB/Swiss-Prot
    Q9NZF1
    UniProtKB/TrEMBL
    X2BQ60
    Related
    ENSP00000412230.2, ENST00000411416.6
    Conserved Domains (1) summary
    cl04722
    Location:24108
    PLAC8; PLAC8 family
  3. NM_016619.3NP_057703.1  placenta-specific gene 8 protein

    See identical proteins and their annotated locations for NP_057703.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1.
    Source sequence(s)
    AC073840, AK000140
    Consensus CDS
    CCDS3601.1
    UniProtKB/Swiss-Prot
    Q9NZF1
    UniProtKB/TrEMBL
    X2BQ60
    Related
    ENSP00000309509.4, ENST00000311507.8
    Conserved Domains (1) summary
    cl04722
    Location:24108
    PLAC8; PLAC8 family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    83090048..83114729 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center