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SLC25A37 solute carrier family 25 member 37 [ Homo sapiens (human) ]

Gene ID: 51312, updated on 20-Mar-2020

Summary

Official Symbol
SLC25A37provided by HGNC
Official Full Name
solute carrier family 25 member 37provided by HGNC
Primary source
HGNC:HGNC:29786
See related
Ensembl:ENSG00000147454 MIM:610387
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MSC; MFRN; MSCP; HT015; MFRN1; PRO1278; PRO1584; PRO2217
Summary
SLC25A37 is a solute carrier localized in the mitochondrial inner membrane. It functions as an essential iron importer for the synthesis of mitochondrial heme and iron-sulfur clusters (summary by Chen et al., 2009 [PubMed 19805291]).[supplied by OMIM, Jan 2011]
Expression
Broad expression in bone marrow (RPKM 58.8), duodenum (RPKM 28.2) and 21 other tissues See more
Orthologs

Genomic context

See SLC25A37 in Genome Data Viewer
Location:
8p21.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (23528956..23575463)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (23386363..23432976)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379327 Neighboring gene CRISPRi-validated cis-regulatory element chr8.847 Neighboring gene RNA, U4 small nuclear 71, pseudogene Neighboring gene SINHCAF pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
iron ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
iron import into the mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
iron ion homeostasis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
mitoferrin-1
Names
mitochondrial iron transporter 1
mitochondrial solute carrier protein
mitoferrin
predicted protein of HQ2217
solute carrier family 25 (mitochondrial iron transporter), member 37

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317812.2NP_001304741.1  mitoferrin-1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses a downstream translation start site compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC051642
    UniProtKB/Swiss-Prot
    Q9NYZ2
    UniProtKB/TrEMBL
    Q71JB2
    Conserved Domains (1) summary
    pfam00153
    Location:173
    Mito_carr; Mitochondrial carrier protein
  2. NM_001317813.2NP_001304742.1  mitoferrin-1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses a downstream translation start site compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1. Both variants 3 and 4 encode the same isoform (3).
    Source sequence(s)
    AC051642
    UniProtKB/Swiss-Prot
    Q9NYZ2
    UniProtKB/TrEMBL
    Q71JB2
    Conserved Domains (1) summary
    pfam00153
    Location:70152
    Mito_carr; Mitochondrial carrier protein
  3. NM_001317814.2NP_001304743.1  mitoferrin-1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and uses a downstream translation start site compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1. Both variants 3 and 4 encode the same isoform (3).
    Source sequence(s)
    AC051642
    UniProtKB/Swiss-Prot
    Q9NYZ2
    UniProtKB/TrEMBL
    Q71JB2
    Conserved Domains (1) summary
    pfam00153
    Location:70152
    Mito_carr; Mitochondrial carrier protein
  4. NM_016612.4NP_057696.2  mitoferrin-1 isoform 1

    See identical proteins and their annotated locations for NP_057696.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shortest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC051642
    Consensus CDS
    CCDS47828.1
    UniProtKB/Swiss-Prot
    Q9NYZ2
    UniProtKB/TrEMBL
    Q71JB2
    Related
    ENSP00000429200.1, ENST00000519973.6
    Conserved Domains (1) summary
    pfam00153
    Location:44136
    Mito_carr; Mitochondrial carrier protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    23528956..23575463
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544553.2XP_011542855.1  mitoferrin-1 isoform X2

    See identical proteins and their annotated locations for XP_011542855.1

    Conserved Domains (1) summary
    pfam00153
    Location:70152
    Mito_carr; Mitochondrial carrier protein
  2. XM_017013532.1XP_016869021.1  mitoferrin-1 isoform X2

    Conserved Domains (1) summary
    pfam00153
    Location:70152
    Mito_carr; Mitochondrial carrier protein
  3. XM_011544554.2XP_011542856.1  mitoferrin-1 isoform X3

    See identical proteins and their annotated locations for XP_011542856.1

    UniProtKB/Swiss-Prot
    Q9NYZ2
    Related
    ENST00000523883.5
    Conserved Domains (1) summary
    pfam00153
    Location:173
    Mito_carr; Mitochondrial carrier protein
  4. XM_011544550.2XP_011542852.1  mitoferrin-1 isoform X1

    Conserved Domains (1) summary
    pfam00153
    Location:76158
    Mito_carr; Mitochondrial carrier protein
  5. XM_006716352.3XP_006716415.1  mitoferrin-1 isoform X2

    See identical proteins and their annotated locations for XP_006716415.1

    Conserved Domains (1) summary
    pfam00153
    Location:70152
    Mito_carr; Mitochondrial carrier protein
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