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ZDHHC3 zDHHC palmitoyltransferase 3 [ Homo sapiens (human) ]

Gene ID: 51304, updated on 12-Jun-2025
Official Symbol
ZDHHC3provided by HGNC
Official Full Name
zDHHC palmitoyltransferase 3provided by HGNC
Primary source
HGNC:HGNC:18470
See related
Ensembl:ENSG00000163812 MIM:617150; AllianceGenome:HGNC:18470
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GODZ; DHHC3; DHHC-3; ZNF373
Summary
Enables palmitoyltransferase activity. Involved in several processes, including protein localization to membrane; protein localization to photoreceptor outer segment; and regulation of signal transduction. Located in membrane. Is active in Golgi apparatus. [provided by Alliance of Genome Resources, Jun 2025]
Expression
Ubiquitous expression in testis (RPKM 9.5), skin (RPKM 8.8) and 25 other tissues See more
Orthologs
NEW
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Try the new Transcript table
See ZDHHC3 in Genome Data Viewer
Location:
3p21.31
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (44915261..44976174, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (44930989..44991916, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (44956753..45017666, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:44925386-44926063 Neighboring gene peptidylprolyl isomerase A pseudogene 18 Neighboring gene Sharpr-MPRA regulatory region 3821 Neighboring gene transglutaminase 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:44940040-44940581 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:44975255-44976082 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:44981025-44981526 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:44981527-44982026 Neighboring gene ribosomal protein L12 pseudogene 44 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:45000471-45001670 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:45016646-45017190 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14275 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14276 Neighboring gene exosome component 7 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19773 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:45068175-45068676 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:45068677-45069176 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:45075939-45076588 Neighboring gene C-type lectin domain family 3 member B Neighboring gene RNA, U5B small nuclear 3, pseudogene

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EBI GWAS Catalog

Description
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
EBI GWAS Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • FLJ20209, FLJ45940, DKFZp313D2314

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables palmitoyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables palmitoyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein-cysteine S-myristoyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein-cysteine S-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein-cysteine S-palmitoyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein-cysteine S-palmitoyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein-cysteine S-palmitoyltransferase activity TAS
Traceable Author Statement
more info
PubMed 
enables protein-cysteine S-stearoyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within TRAIL-activated apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within TRAIL-activated apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in TRAIL-activated apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular response to nutrient levels IDA
Inferred from Direct Assay
more info
PubMed 
involved_in lipoprotein localization to membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptidyl-L-cysteine S-palmitoylation ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within positive regulation of TORC1 signaling IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of protein localization to lysosome IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of receptor localization to synapse IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of receptor localization to synapse ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of synaptic transmission, GABAergic IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of synaptic transmission, GABAergic ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of toll-like receptor 9 signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein localization to membrane TAS
Traceable Author Statement
more info
PubMed 
involved_in protein localization to photoreceptor outer segment IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein localization to plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein palmitoylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein palmitoylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein targeting IEA
Inferred from Electronic Annotation
more info
 
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within toll-like receptor 9 signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
located_in Golgi membrane TAS
Traceable Author Statement
more info
 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
palmitoyltransferase ZDHHC3
Names
DHHC1 protein
Golgi apparatus-specific protein with DHHC zinc finger domain
acyltransferase ZDHHC3
golgi-specific DHHC Zinc Finger Protein
zinc finger DHHC domain-containing protein 3
zinc finger DHHC-type containing 3
zinc finger DHHC-type palmitoyltransferase 3
zinc finger protein 373
zinc finger, DHHC domain containing 3
NP_001128651.1
NP_001317690.1
NP_001336305.1
NP_001336306.1
NP_001336307.1
NP_001336308.1
NP_001336309.1
NP_001336310.1
NP_057682.1
XP_016862050.1
XP_016862051.1
XP_016862057.1
XP_024309326.2
XP_024309327.2
XP_047304216.1
XP_047304217.1
XP_047304218.1
XP_047304219.1
XP_047304220.1
XP_047304221.1
XP_047304222.1
XP_047304224.1
XP_047304225.1
XP_047304226.1
XP_047304227.1
XP_054202729.1
XP_054202730.1
XP_054202731.1
XP_054202732.1
XP_054202733.1
XP_054202734.1
XP_054202735.1
XP_054202736.1
XP_054202737.1
XP_054202738.1
XP_054202739.1
XP_054202740.1
XP_054202741.1
XP_054202742.1
XP_054202743.1
XP_054202744.1
XP_054202745.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135179.2NP_001128651.1  palmitoyltransferase ZDHHC3 isoform 1

    See identical proteins and their annotated locations for NP_001128651.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1), as well as variants 9 and 10, encodes isoform 1.
    Source sequence(s)
    AA778122, AC098649, AC104165, AK000216, BC015467, DB636483
    Consensus CDS
    CCDS46811.1
    UniProtKB/Swiss-Prot
    Q53A17, Q96BL0, Q9NYG2
    Related
    ENSP00000395502.2, ENST00000424952.7
    Conserved Domains (1) summary
    pfam01529
    Location:128255
    DHHC; DHHC palmitoyltransferase
  2. NM_001330761.2NP_001317690.1  palmitoyltransferase ZDHHC3 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents the longest transcript and encodes isoform 4.
    Source sequence(s)
    AC098649, AC104165
    Consensus CDS
    CCDS87071.1
    UniProtKB/TrEMBL
    F8W6M3
    Related
    ENSP00000345268.4, ENST00000342790.8
    Conserved Domains (1) summary
    pfam01529
    Location:162289
    DHHC; DHHC palmitoyltransferase
  3. NM_001349376.2NP_001336305.1  palmitoyltransferase ZDHHC3 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) encodes the longest isoform (5).
    Source sequence(s)
    AC098649, AC104165
    Consensus CDS
    CCDS93256.1
    UniProtKB/TrEMBL
    A0A994J7J2
    Related
    ENSP00000516198.1, ENST00000705994.1
    Conserved Domains (2) summary
    pfam01529
    Location:128283
    zf-DHHC; DHHC palmitoyltransferase
    cl19890
    Location:52194
    zf-DHHC; DHHC palmitoyltransferase
  4. NM_001349377.2NP_001336306.1  palmitoyltransferase ZDHHC3 isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) encodes isoform 6.
    Source sequence(s)
    AC098649, AC104165
    Consensus CDS
    CCDS46810.1
    UniProtKB/TrEMBL
    H0Y6A5
    Related
    ENSP00000404108.2, ENST00000339420.7
    Conserved Domains (1) summary
    pfam01529
    Location:128255
    zf-DHHC; DHHC palmitoyltransferase
  5. NM_001349378.2NP_001336307.1  palmitoyltransferase ZDHHC3 isoform 7

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) encodes isoform 7.
    Source sequence(s)
    AC098649, AC104165
    Conserved Domains (1) summary
    pfam01529
    Location:54209
    zf-DHHC; DHHC palmitoyltransferase
  6. NM_001349379.2NP_001336308.1  palmitoyltransferase ZDHHC3 isoform 8

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) encodes isoform 8.
    Source sequence(s)
    AC098649, AC104165
    Conserved Domains (1) summary
    pfam01529
    Location:54181
    DHHC; DHHC palmitoyltransferase
  7. NM_001349380.2NP_001336309.1  palmitoyltransferase ZDHHC3 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9), as well as variants 1 and 10, encodes isoform 1.
    Source sequence(s)
    AC098649, AC104165
    Consensus CDS
    CCDS46811.1
    UniProtKB/Swiss-Prot
    Q53A17, Q96BL0, Q9NYG2
    Conserved Domains (1) summary
    pfam01529
    Location:128255
    DHHC; DHHC palmitoyltransferase
  8. NM_001349381.2NP_001336310.1  palmitoyltransferase ZDHHC3 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10), as well as variants 1 and 9, encodes isoform 1.
    Source sequence(s)
    AC098649, AC104165
    Consensus CDS
    CCDS46811.1
    UniProtKB/Swiss-Prot
    Q53A17, Q96BL0, Q9NYG2
    Conserved Domains (1) summary
    pfam01529
    Location:128255
    DHHC; DHHC palmitoyltransferase
  9. NM_016598.3NP_057682.1  palmitoyltransferase ZDHHC3 isoform 2

    See identical proteins and their annotated locations for NP_057682.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) encodes isoform 2.
    Source sequence(s)
    AA778122, AC098649, AC104165, AF247703, AK000216, DB636483
    Consensus CDS
    CCDS2724.1
    UniProtKB/Swiss-Prot
    Q9NYG2
    Related
    ENSP00000296127.3, ENST00000296127.7
    Conserved Domains (2) summary
    pfam01529
    Location:129283
    zf-DHHC; DHHC palmitoyltransferase
    cl19890
    Location:52194
    zf-DHHC; DHHC palmitoyltransferase

RNA

  1. NR_146161.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC098649, AC104165
  2. NR_146162.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC098649, AC104165
  3. NR_146163.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC098649, AC104165

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    44915261..44976174 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017006562.2XP_016862051.1  palmitoyltransferase ZDHHC3 isoform X6

  2. XM_017006561.2XP_016862050.1  palmitoyltransferase ZDHHC3 isoform X4

  3. XM_047448265.1XP_047304221.1  palmitoyltransferase ZDHHC3 isoform X5

  4. XM_047448264.1XP_047304220.1  palmitoyltransferase ZDHHC3 isoform X3

  5. XM_047448263.1XP_047304219.1  palmitoyltransferase ZDHHC3 isoform X2

  6. XM_047448260.1XP_047304216.1  palmitoyltransferase ZDHHC3 isoform X1

  7. XM_047448266.1XP_047304222.1  palmitoyltransferase ZDHHC3 isoform X14

    UniProtKB/TrEMBL
    A0A994J7J2
  8. XM_047448261.1XP_047304217.1  palmitoyltransferase ZDHHC3 isoform X1

  9. XM_047448262.1XP_047304218.1  palmitoyltransferase ZDHHC3 isoform X1

  10. XM_017006568.1XP_016862057.1  palmitoyltransferase ZDHHC3 isoform X13

  11. XM_047448268.1XP_047304224.1  palmitoyltransferase ZDHHC3 isoform X9

  12. XM_024453558.2XP_024309326.2  palmitoyltransferase ZDHHC3 isoform X7

  13. XM_047448271.1XP_047304227.1  palmitoyltransferase ZDHHC3 isoform X12

  14. XM_047448270.1XP_047304226.1  palmitoyltransferase ZDHHC3 isoform X11

  15. XM_047448269.1XP_047304225.1  palmitoyltransferase ZDHHC3 isoform X10

  16. XM_024453559.2XP_024309327.2  palmitoyltransferase ZDHHC3 isoform X8

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_009646197.1 Reference GRCh38.p14 PATCHES

    Range
    440611..451168 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    44930989..44991916 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054346762.1XP_054202737.1  palmitoyltransferase ZDHHC3 isoform X6

  2. XM_054346759.1XP_054202734.1  palmitoyltransferase ZDHHC3 isoform X4

  3. XM_054346760.1XP_054202735.1  palmitoyltransferase ZDHHC3 isoform X5

  4. XM_054346758.1XP_054202733.1  palmitoyltransferase ZDHHC3 isoform X3

  5. XM_054346757.1XP_054202732.1  palmitoyltransferase ZDHHC3 isoform X2

  6. XM_054346754.1XP_054202729.1  palmitoyltransferase ZDHHC3 isoform X1

  7. XM_054346763.1XP_054202738.1  palmitoyltransferase ZDHHC3 isoform X14

    UniProtKB/TrEMBL
    H0Y6A5
  8. XM_054346761.1XP_054202736.1  palmitoyltransferase ZDHHC3 isoform X14

    UniProtKB/TrEMBL
    A0A994J7J2
  9. XM_054346755.1XP_054202730.1  palmitoyltransferase ZDHHC3 isoform X1

  10. XM_054346756.1XP_054202731.1  palmitoyltransferase ZDHHC3 isoform X1

  11. XM_054346770.1XP_054202745.1  palmitoyltransferase ZDHHC3 isoform X13

  12. XM_054346766.1XP_054202741.1  palmitoyltransferase ZDHHC3 isoform X9

  13. XM_054346764.1XP_054202739.1  palmitoyltransferase ZDHHC3 isoform X7

  14. XM_054346769.1XP_054202744.1  palmitoyltransferase ZDHHC3 isoform X12

  15. XM_054346768.1XP_054202743.1  palmitoyltransferase ZDHHC3 isoform X11

  16. XM_054346767.1XP_054202742.1  palmitoyltransferase ZDHHC3 isoform X10

  17. XM_054346765.1XP_054202740.1  palmitoyltransferase ZDHHC3 isoform X8

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001135180.1: Suppressed sequence

    Description
    NM_001135180.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.