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ZDHHC3 zinc finger DHHC-type palmitoyltransferase 3 [ Homo sapiens (human) ]

Gene ID: 51304, updated on 1-Jun-2020

Summary

Official Symbol
ZDHHC3provided by HGNC
Official Full Name
zinc finger DHHC-type palmitoyltransferase 3provided by HGNC
Primary source
HGNC:HGNC:18470
See related
Ensembl:ENSG00000163812 MIM:617150
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GODZ; DHHC3; DHHC-3; ZNF373
Expression
Ubiquitous expression in testis (RPKM 9.5), skin (RPKM 8.8) and 25 other tissues See more
Orthologs

Genomic context

See ZDHHC3 in Genome Data Viewer
Location:
3p21.31
Exon count:
14
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (44915261..44976182, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (44956753..45017674, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 3821 Neighboring gene peptidylprolyl isomerase A pseudogene 18 Neighboring gene transglutaminase 4 Neighboring gene ribosomal protein L12 pseudogene 44 Neighboring gene exosome component 7 Neighboring gene C-type lectin domain family 3 member B Neighboring gene RNA, U5B small nuclear 3, pseudogene Neighboring gene CUB domain containing protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20209, FLJ45940, DKFZp313D2314

Gene Ontology Provided by GOA

Function Evidence Code Pubs
palmitoyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein-cysteine S-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein-cysteine S-palmitoyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
TRAIL-activated apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
lipoprotein localization to membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-L-cysteine S-palmitoylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-L-cysteine S-palmitoylation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of receptor localization to synapse ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of synaptic transmission, GABAergic ISS
Inferred from Sequence or Structural Similarity
more info
 
protein localization to photoreceptor outer segment IDA
Inferred from Direct Assay
more info
PubMed 
protein localization to plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein palmitoylation IDA
Inferred from Direct Assay
more info
PubMed 
protein palmitoylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 

General protein information

Preferred Names
palmitoyltransferase ZDHHC3
Names
DHHC1 protein
Golgi apparatus-specific protein with DHHC zinc finger domain
golgi-specific DHHC Zinc Finger Protein
zinc finger DHHC domain-containing protein 3
zinc finger DHHC-type containing 3
zinc finger protein 373
zinc finger, DHHC domain containing 3
NP_001128651.1
NP_001317690.1
NP_001336305.1
NP_001336306.1
NP_001336307.1
NP_001336308.1
NP_001336309.1
NP_001336310.1
NP_057682.1
XP_016862050.1
XP_016862051.1
XP_016862054.1
XP_016862057.1
XP_016862059.1
XP_024309323.1
XP_024309324.1
XP_024309325.1
XP_024309326.1
XP_024309327.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135179.2NP_001128651.1  palmitoyltransferase ZDHHC3 isoform 1

    See identical proteins and their annotated locations for NP_001128651.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1), as well as variants 9 and 10, encodes isoform 1.
    Source sequence(s)
    AA778122, AC098649, AC104165, AK000216, BC015467, DB636483
    Consensus CDS
    CCDS46811.1
    UniProtKB/Swiss-Prot
    Q9NYG2
    Related
    ENSP00000395502.2, ENST00000424952.7
    Conserved Domains (1) summary
    pfam01529
    Location:128255
    zf-DHHC; DHHC palmitoyltransferase
  2. NM_001330761.2NP_001317690.1  palmitoyltransferase ZDHHC3 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents the longest transcript and encodes isoform 4.
    Source sequence(s)
    AC098649, AC104165
    Consensus CDS
    CCDS87071.1
    UniProtKB/TrEMBL
    F8W6M3
    Related
    ENSP00000345268.4, ENST00000342790.8
    Conserved Domains (1) summary
    pfam01529
    Location:162289
    zf-DHHC; DHHC palmitoyltransferase
  3. NM_001349376.2NP_001336305.1  palmitoyltransferase ZDHHC3 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) encodes the longest isoform (5).
    Source sequence(s)
    AC098649, AC104165
    Conserved Domains (2) summary
    pfam01529
    Location:128283
    zf-DHHC; DHHC palmitoyltransferase
    cl19890
    Location:52194
    zf-DHHC; DHHC palmitoyltransferase
  4. NM_001349377.2NP_001336306.1  palmitoyltransferase ZDHHC3 isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) encodes isoform 6.
    Source sequence(s)
    AC098649, AC104165
    Related
    ENSP00000404108.2, ENST00000339420.7
    Conserved Domains (1) summary
    pfam01529
    Location:128255
    zf-DHHC; DHHC palmitoyltransferase
  5. NM_001349378.2NP_001336307.1  palmitoyltransferase ZDHHC3 isoform 7

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) encodes isoform 7.
    Source sequence(s)
    AC098649, AC104165
    Conserved Domains (1) summary
    pfam01529
    Location:54209
    zf-DHHC; DHHC palmitoyltransferase
  6. NM_001349379.2NP_001336308.1  palmitoyltransferase ZDHHC3 isoform 8

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) encodes isoform 8.
    Source sequence(s)
    AC098649, AC104165
    Conserved Domains (1) summary
    pfam01529
    Location:54181
    DHHC; DHHC palmitoyltransferase
  7. NM_001349380.2NP_001336309.1  palmitoyltransferase ZDHHC3 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9), as well as variants 1 and 10, encodes isoform 1.
    Source sequence(s)
    AC098649, AC104165
    Consensus CDS
    CCDS46811.1
    Conserved Domains (1) summary
    pfam01529
    Location:128255
    zf-DHHC; DHHC palmitoyltransferase
  8. NM_001349381.2NP_001336310.1  palmitoyltransferase ZDHHC3 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10), as well as variants 1 and 9, encodes isoform 1.
    Source sequence(s)
    AC098649, AC104165
    Consensus CDS
    CCDS46811.1
    Conserved Domains (1) summary
    pfam01529
    Location:128255
    zf-DHHC; DHHC palmitoyltransferase
  9. NM_016598.3NP_057682.1  palmitoyltransferase ZDHHC3 isoform 2

    See identical proteins and their annotated locations for NP_057682.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) encodes isoform 2.
    Source sequence(s)
    AA778122, AC098649, AC104165, AF247703, AK000216, DB636483
    Consensus CDS
    CCDS2724.1
    UniProtKB/Swiss-Prot
    Q9NYG2
    Related
    ENSP00000296127.3, ENST00000296127.7
    Conserved Domains (2) summary
    pfam01529
    Location:129283
    zf-DHHC; DHHC palmitoyltransferase
    cl19890
    Location:52194
    zf-DHHC; DHHC palmitoyltransferase

RNA

  1. NR_146161.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC098649, AC104165
  2. NR_146162.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC098649, AC104165
  3. NR_146163.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC098649, AC104165

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    44915261..44976182 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017006562.1XP_016862051.1  palmitoyltransferase ZDHHC3 isoform X5

  2. XM_017006561.1XP_016862050.1  palmitoyltransferase ZDHHC3 isoform X2

  3. XM_017006565.1XP_016862054.1  palmitoyltransferase ZDHHC3 isoform X8

  4. XM_017006570.1XP_016862059.1  palmitoyltransferase ZDHHC3 isoform X10

  5. XM_017006568.1XP_016862057.1  palmitoyltransferase ZDHHC3 isoform X9

  6. XM_024453556.1XP_024309324.1  palmitoyltransferase ZDHHC3 isoform X3

    Conserved Domains (1) summary
    pfam01529
    Location:54181
    zf-DHHC; DHHC palmitoyltransferase
  7. XM_024453555.1XP_024309323.1  palmitoyltransferase ZDHHC3 isoform X1

    Conserved Domains (1) summary
    pfam01529
    Location:54173
    zf-DHHC; DHHC palmitoyltransferase
  8. XM_024453558.1XP_024309326.1  palmitoyltransferase ZDHHC3 isoform X6

    Conserved Domains (1) summary
    pfam01529
    Location:54201
    zf-DHHC; DHHC palmitoyltransferase
  9. XM_024453559.1XP_024309327.1  palmitoyltransferase ZDHHC3 isoform X7

    Conserved Domains (1) summary
    pfam01529
    Location:54202
    zf-DHHC; DHHC palmitoyltransferase
  10. XM_024453557.1XP_024309325.1  palmitoyltransferase ZDHHC3 isoform X4

    Conserved Domains (1) summary
    pfam01529
    Location:54209
    zf-DHHC; DHHC palmitoyltransferase

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_009646197.1 Reference GRCh38.p13 PATCHES

    Range
    440611..451168 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001135180.1: Suppressed sequence

    Description
    NM_001135180.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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