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FKBP11 FKBP prolyl isomerase 11 [ Homo sapiens (human) ]

Gene ID: 51303, updated on 9-Feb-2020

Summary

Official Symbol
FKBP11provided by HGNC
Official Full Name
FKBP prolyl isomerase 11provided by HGNC
Primary source
HGNC:HGNC:18624
See related
Ensembl:ENSG00000134285 MIM:610571
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FKBP19
Summary
FKBP11 belongs to the FKBP family of peptidyl-prolyl cis/trans isomerases, which catalyze the folding of proline-containing polypeptides. The peptidyl-prolyl isomerase activity of FKBP proteins is inhibited by the immunosuppressant compounds FK506 and rapamycin (Rulten et al., 2006 [PubMed 16596453]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in pancreas (RPKM 27.0), appendix (RPKM 17.8) and 24 other tissues See more
Orthologs

Genomic context

See FKBP11 in Genome Data Viewer
Location:
12q13.12
Exon count:
8
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (48921963..48925547, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (49315742..49319330, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein L32 pseudogene 27 Neighboring gene coiled-coil domain containing 65 Neighboring gene ADP ribosylation factor 3 Neighboring gene Wnt family member 10B Neighboring gene RNA, U6 small nuclear 940, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC54182

Gene Ontology Provided by GOA

Function Evidence Code Pubs
peptidyl-prolyl cis-trans isomerase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
protein peptidyl-prolyl isomerization IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 

General protein information

Preferred Names
peptidyl-prolyl cis-trans isomerase FKBP11
Names
19 kDa FK506-binding protein
19 kDa FKBP
FK506 binding protein 11, 19 kDa
FK506-binding protein 11
FKBP-11
FKBP-19
PPIase FKBP11
rotamase
NP_001137253.1
NP_001137254.1
NP_057678.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001143781.2NP_001137253.1  peptidyl-prolyl cis-trans isomerase FKBP11 isoform 2

    See identical proteins and their annotated locations for NP_001137253.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC073610, AY358998, BE857354
    Consensus CDS
    CCDS44870.1
    UniProtKB/Swiss-Prot
    Q9NYL4
    UniProtKB/TrEMBL
    E9PAR0
    Related
    ENSP00000412403.2, ENST00000444214.6
    Conserved Domains (2) summary
    pfam00254
    Location:139
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
    cl02291
    Location:5082
    DUF2189; Predicted integral membrane protein (DUF2189)
  2. NM_001143782.1NP_001137254.1  peptidyl-prolyl cis-trans isomerase FKBP11 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001137254.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK301455, DA378205
    Consensus CDS
    CCDS44871.1
    UniProtKB/Swiss-Prot
    Q9NYL4
    Related
    ENSP00000396874.2, ENST00000453172.2
    Conserved Domains (1) summary
    pfam00254
    Location:50128
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
  3. NM_016594.3NP_057678.1  peptidyl-prolyl cis-trans isomerase FKBP11 isoform 1 precursor

    See identical proteins and their annotated locations for NP_057678.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AY358998
    Consensus CDS
    CCDS8773.1
    UniProtKB/Swiss-Prot
    Q9NYL4
    Related
    ENSP00000449751.1, ENST00000550765.6
    Conserved Domains (1) summary
    pfam00254
    Location:50141
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    48921963..48925547 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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