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GCNT4 glucosaminyl (N-acetyl) transferase 4 [ Homo sapiens (human) ]

Gene ID: 51301, updated on 30-Oct-2022

Summary

Official Symbol
GCNT4provided by HGNC
Official Full Name
glucosaminyl (N-acetyl) transferase 4provided by HGNC
Primary source
HGNC:HGNC:17973
See related
Ensembl:ENSG00000176928 MIM:616782; AllianceGenome:HGNC:17973
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C2GNT3; LINC01336
Summary
Predicted to enable acetylglucosaminyltransferase activity. Predicted to be involved in O-glycan processing and carbohydrate metabolic process. Predicted to act upstream of or within several processes, including inter-male aggressive behavior; kidney morphogenesis; and thyroid hormone metabolic process. Predicted to be located in Golgi membrane. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See GCNT4 in Genome Data Viewer
Location:
5q13.3
Exon count:
8
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (75016969..75054060, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (75506196..75533414, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (74321171..74348383, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379040 Neighboring gene Sharpr-MPRA regulatory region 2499 Neighboring gene ribosomal protein L27a pseudogene 5 Neighboring gene ankyrin repeat domain 31 Neighboring gene uncharacterized LOC124901006 Neighboring gene SUMO2 pseudogene 5

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortiu
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in O-glycan processing TAS
Traceable Author Statement
more info
 
involved_in carbohydrate metabolic process TAS
Traceable Author Statement
more info
PubMed 
involved_in inter-male aggressive behavior IEA
Inferred from Electronic Annotation
more info
 
involved_in kidney morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in neutrophil homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in protein O-linked glycosylation TAS
Traceable Author Statement
more info
PubMed 
involved_in thyroid hormone metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in tissue morphogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4
Names
core 2 beta-1,6-N-acetylglucosaminyltransferase 3
core 2-branching enzyme 3
core2-GlcNAc-transferase 3
glucosaminyl (N-acetyl) transferase 4, core 2 (beta-1,6-N-acetylglucosaminyltransferase)
long intergenic non-protein coding RNA 1336
NP_001353666.1
XP_047273227.1
XP_047273228.1
XP_047273229.1
XP_047273230.1
XP_047273231.1
XP_047273232.1
XP_047273233.1
XP_047273234.1
XP_047273235.1
XP_047273236.1
XP_047273237.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001366737.1NP_001353666.1  beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4

    Status: VALIDATED

    Source sequence(s)
    AC093259
    Consensus CDS
    CCDS4026.1
    UniProtKB/Swiss-Prot
    Q9P109
    Related
    ENSP00000498836.1, ENST00000652361.2
    Conserved Domains (1) summary
    cl27418
    Location:133402
    Branch; Core-2/I-Branching enzyme

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    75016969..75054060 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047417280.1XP_047273236.1  beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4 isoform X1

    UniProtKB/Swiss-Prot
    Q9P109
    Related
    ENSP00000317027.4, ENST00000322348.5
  2. XM_047417272.1XP_047273228.1  beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4 isoform X1

    UniProtKB/Swiss-Prot
    Q9P109
  3. XM_047417276.1XP_047273232.1  beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4 isoform X1

    UniProtKB/Swiss-Prot
    Q9P109
  4. XM_047417274.1XP_047273230.1  beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4 isoform X1

    UniProtKB/Swiss-Prot
    Q9P109
  5. XM_047417278.1XP_047273234.1  beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4 isoform X1

    UniProtKB/Swiss-Prot
    Q9P109
  6. XM_047417273.1XP_047273229.1  beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4 isoform X1

    UniProtKB/Swiss-Prot
    Q9P109
  7. XM_047417275.1XP_047273231.1  beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4 isoform X1

    UniProtKB/Swiss-Prot
    Q9P109
  8. XM_047417281.1XP_047273237.1  beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4 isoform X1

    UniProtKB/Swiss-Prot
    Q9P109
  9. XM_047417271.1XP_047273227.1  beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4 isoform X1

    UniProtKB/Swiss-Prot
    Q9P109
  10. XM_047417279.1XP_047273235.1  beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4 isoform X1

    UniProtKB/Swiss-Prot
    Q9P109
  11. XM_047417277.1XP_047273233.1  beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4 isoform X1

    UniProtKB/Swiss-Prot
    Q9P109

RNA

  1. XR_007058605.1 RNA Sequence

  2. XR_007058606.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    75506196..75533414 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_016591.2: Suppressed sequence

    Description
    NM_016591.2: This RefSeq was removed because currently there is insufficient support for the transcript.
  2. NR_126375.1: Suppressed sequence

    Description
    NR_126375.1: This RefSeq was removed because currently there is insufficient support for the transcript.