Format

Send to:

Choose Destination

ATP5F1D ATP synthase F1 subunit delta [ Homo sapiens (human) ]

Gene ID: 513, updated on 4-Nov-2018

Summary

Official Symbol
ATP5F1Dprovided by HGNC
Official Full Name
ATP synthase F1 subunit deltaprovided by HGNC
Primary source
HGNC:HGNC:837
See related
Ensembl:ENSG00000099624 MIM:603150; Vega:OTTHUMG00000180143
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ATP5D; MC5DN5
Summary
This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the delta subunit of the catalytic core. Alternatively spliced transcript variants encoding the same isoform have been identified. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in kidney (RPKM 30.9), colon (RPKM 30.8) and 25 other tissues See more
Orthologs

Genomic context

See ATP5F1D in Genome Data Viewer
Location:
19p13.3
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (1241750..1244825)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (1241749..1244824)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene serine/threonine kinase 11 Neighboring gene serine/threonine kinase 11 intron 3 Alu-mediated recombination region Neighboring gene CACN subunit beta associated regulatory protein Neighboring gene uncharacterized LOC102723811 Neighboring gene midnolin

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies downregulation of ATP synthase, F1 complex, delta subunit (ATP5D) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed
Vpu vpu HIV-1 Vpu is identified to have a physical interaction with ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit (ATP5D) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to ADP binding NAS
Non-traceable Author Statement
more info
PubMed 
contributes_to ATP binding NAS
Non-traceable Author Statement
more info
PubMed 
contributes_to ATPase activity IDA
Inferred from Direct Assay
more info
PubMed 
ATPase activity NAS
Non-traceable Author Statement
more info
PubMed 
contributes_to proton-transporting ATP synthase activity, rotational mechanism IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmembrane transporter activity IC
Inferred by Curator
more info
PubMed 
transporter activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
ATP biosynthetic process NAS
Non-traceable Author Statement
more info
PubMed 
ATP biosynthetic process TAS
Traceable Author Statement
more info
 
ATP hydrolysis coupled cation transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
ATP synthesis coupled proton transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cristae formation TAS
Traceable Author Statement
more info
 
mitochondrial ATP synthesis coupled proton transport IC
Inferred by Curator
more info
PubMed 
mitochondrial ATP synthesis coupled proton transport NAS
Non-traceable Author Statement
more info
PubMed 
oxidative phosphorylation NAS
Non-traceable Author Statement
more info
PubMed 
response to copper ion NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
mitochondrial matrix TAS
Traceable Author Statement
more info
 
mitochondrial proton-transporting ATP synthase complex IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial proton-transporting ATP synthase complex NAS
Non-traceable Author Statement
more info
PubMed 
mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) NAS
Non-traceable Author Statement
more info
PubMed 
mitochondrion NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
ATP synthase subunit delta, mitochondrial
Names
ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit
F-ATPase delta subunit
mitochondrial ATP synthase complex delta-subunit precusor
mitochondrial ATP synthase, delta subunit
NP_001001975.1
NP_001678.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001975.1NP_001001975.1  ATP synthase subunit delta, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001001975.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks a segment in the 3' UTR, compared to variant 1. Both variants encode the same isoform.
    Source sequence(s)
    BC018817, X63423
    Consensus CDS
    CCDS12058.1
    UniProtKB/Swiss-Prot
    P30049
    Related
    ENSP00000378995.1, OTTHUMP00000274767, ENST00000395633.5, OTTHUMT00000473909
    Conserved Domains (1) summary
    cd12152
    Location:38162
    F1-ATPase_delta; mitochondrial ATP synthase delta subunit
  2. NM_001687.4NP_001678.1  ATP synthase subunit delta, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001678.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants encode the same isoform.
    Source sequence(s)
    BC018817, X63422
    Consensus CDS
    CCDS12058.1
    UniProtKB/Swiss-Prot
    P30049
    Related
    ENSP00000215375.1, OTTHUMP00000263448, ENST00000215375.6, OTTHUMT00000449958
    Conserved Domains (1) summary
    cd12152
    Location:38162
    F1-ATPase_delta; mitochondrial ATP synthase delta subunit

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    1241750..1244825
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center