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THEG theg spermatid protein [ Homo sapiens (human) ]

Gene ID: 51298, updated on 25-Jan-2022

Summary

Official Symbol
THEGprovided by HGNC
Official Full Name
theg spermatid proteinprovided by HGNC
Primary source
HGNC:HGNC:13706
See related
Ensembl:ENSG00000105549 MIM:609503; AllianceGenome:HGNC:13706
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT56; THEG1
Summary
This gene is specifically expressed in the nucleus of haploid male germ cells. The orthologous gene in mice encodes a protein that may play a role in protein assembly through interactions with T-complex protein 1 subunit epsilon. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Expression
Restricted expression toward testis (RPKM 7.1) See more
Orthologs
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Genomic context

See THEG in Genome Data Viewer
Location:
19p13.3
Exon count:
10
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (361747..376693, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (361747..376026, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene PLPP2 intron CAGE-defined low expression enhancer Neighboring gene phospholipid phosphatase 2 Neighboring gene MIER family member 2 Neighboring gene C2 calcium dependent domain containing 4C Neighboring gene SHC adaptor protein 2 Neighboring gene RNA, 5S ribosomal pseudogene 462

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • MGC26138

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in chaperone-mediated protein complex assembly TAS
Traceable Author Statement
more info
PubMed 
involved_in spermatogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
testicular haploid expressed gene protein
Names
Theg homolog
cancer/testis antigen 56
testis-specific

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016585.5NP_057669.1  testicular haploid expressed gene protein isoform 1

    See identical proteins and their annotated locations for NP_057669.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, also known as THEG major) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB033129, AC016588, AF268610
    Consensus CDS
    CCDS12025.1
    UniProtKB/Swiss-Prot
    Q9P2T0
    Related
    ENSP00000340088.3, ENST00000342640.9
    Conserved Domains (1) summary
    pfam14912
    Location:217275
    THEG; Testicular haploid expressed repeat
  2. NM_199202.3NP_954672.1  testicular haploid expressed gene protein isoform 2

    See identical proteins and their annotated locations for NP_954672.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also known as THEG minor) lacks an exon in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AB033129, AC016588, AF268610, DR731298
    Consensus CDS
    CCDS12026.1
    UniProtKB/Swiss-Prot
    Q9P2T0
    Related
    ENSP00000264820.3, ENST00000346878.3
    Conserved Domains (1) summary
    pfam14912
    Location:193251
    THEG; Testicular haploid expressed repeat

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    361747..376693 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528051.2XP_011526353.1  testicular haploid expressed gene protein isoform X3

    Conserved Domains (1) summary
    pfam14912
    Location:185243
    THEG; Testicular haploid expressed repeat
  2. XM_011528049.2XP_011526351.1  testicular haploid expressed gene protein isoform X1

    Conserved Domains (1) summary
    pfam14912
    Location:253311
    THEG; Testicular haploid expressed repeat
  3. XM_011528050.2XP_011526352.1  testicular haploid expressed gene protein isoform X2

    Conserved Domains (1) summary
    pfam14912
    Location:229287
    THEG; Testicular haploid expressed repeat
  4. XM_024451533.1XP_024307301.1  testicular haploid expressed gene protein isoform X5

  5. XM_024451532.1XP_024307300.1  testicular haploid expressed gene protein isoform X4

    Conserved Domains (1) summary
    pfam14912
    Location:185243
    THEG; Testicular haploid expressed repeat
  6. XM_011528052.2XP_011526354.1  testicular haploid expressed gene protein isoform X6

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