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SLC15A3 solute carrier family 15 member 3 [ Homo sapiens (human) ]

Gene ID: 51296, updated on 13-Mar-2020

Summary

Official Symbol
SLC15A3provided by HGNC
Official Full Name
solute carrier family 15 member 3provided by HGNC
Primary source
HGNC:HGNC:18068
See related
Ensembl:ENSG00000110446 MIM:610408
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OCTP; PHT2; PTR3
Expression
Broad expression in spleen (RPKM 20.2), lung (RPKM 17.9) and 23 other tissues See more
Orthologs

Genomic context

See SLC15A3 in Genome Data Viewer
Location:
11q12.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (60937084..60952176, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (60704555..60719257, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369323 Neighboring gene transmembrane protein 109 Neighboring gene transmembrane protein 132A Neighboring gene CD6 molecule Neighboring gene RNA, U6 small nuclear 933, pseudogene Neighboring gene tRNA-Ala (TGC) 10-1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ26631

Gene Ontology Provided by GOA

Function Evidence Code Pubs
oligopeptide transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptide transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptide:proton symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
ion transport TAS
Traceable Author Statement
more info
 
oligopeptide transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
protein transport IEA
Inferred from Electronic Annotation
more info
 
proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
lysosomal membrane HDA PubMed 
lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lysosomal membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
solute carrier family 15 member 3
Names
osteoclast transporter
peptide transporter 3
peptide/histidine transporter 2
solute carrier family 15 (oligopeptide transporter), member 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016582.3NP_057666.1  solute carrier family 15 member 3

    See identical proteins and their annotated locations for NP_057666.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and is protein-coding.
    Source sequence(s)
    AB020598, AP003721, BU731752
    Consensus CDS
    CCDS7998.1
    UniProtKB/Swiss-Prot
    Q8IY34
    Related
    ENSP00000227880.2, ENST00000227880.8
    Conserved Domains (1) summary
    cl21472
    Location:175520
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

RNA

  1. NR_027391.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AB020598, AP003721, BC025710

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    60937084..60952176 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011545095.2XP_011543397.1  solute carrier family 15 member 3 isoform X1

    Related
    ENSP00000445773.1, ENST00000541505.5
    Conserved Domains (1) summary
    cl21472
    Location:175520
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

RNA

  1. XR_949960.2 RNA Sequence

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