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FGD3 FYVE, RhoGEF and PH domain containing 3 [ Bos taurus (domestic cattle) ]

Gene ID: 512950, updated on 3-Dec-2024

Summary

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Official Symbol
FGD3provided by VGNC
Official Full Name
FYVE, RhoGEF and PH domain containing 3provided by VGNC
Primary source
VGNC:VGNC:28966
See related
BGD:BT24630; Ensembl:ENSBTAG00000006939
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See FGD3 in Genome Data Viewer
Location:
chromosome: 8
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 8 NC_037335.1 (84356368..84420638)

Chromosome 8 - NC_037335.1Genomic Context describing neighboring genes Neighboring gene centromere protein P Neighboring gene inositol-pentakisphosphate 2-kinase Neighboring gene BICD cargo adaptor 2 Neighboring gene uncharacterized LOC132345991 Neighboring gene sushi domain containing 3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037335.1 Chromosome 8 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Non-synonymous FGD3 Variant as Positional Candidate for Disproportional Tall Stature Accounting for a Carcass Weight QTL (CW-3) and Skeletal Dysplasia in Japanese Black Cattle. Takasuga A, et al. PLoS Genet, 2015 Aug. PMID 26306008, Free PMC Article
  2. Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries and construction of a gene index for cattle. Smith TP, et al. Genome Res, 2001 Apr. PMID 11282978, Free PMC Article
  3. Characterization of 954 bovine full-CDS cDNA sequences. Harhay GP, et al. BMC Genomics, 2005 Nov 23. PMID 16305752, Free PMC Article
  4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Association of FGD3 mutations with skeletal dysplasia in cattle.
    Title: Non-synonymous FGD3 Variant as Positional Candidate for Disproportional Tall Stature Accounting for a Carcass Weight QTL (CW-3) and Skeletal Dysplasia in Japanese Black Cattle.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in filopodium assembly IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
FYVE, RhoGEF and PH domain-containing protein 3
Names
FGD1 family, member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024527.1 → NP_001019698.1  FYVE, RhoGEF and PH domain-containing protein 3

    See identical proteins and their annotated locations for NP_001019698.1

    Status: PROVISIONAL

    Source sequence(s)
    BT021872
    UniProtKB/TrEMBL
    A0AAF6DMH8, F1MZZ4, Q58CS5
    Related
    ENSBTAP00000009131.5, ENSBTAT00000009131.6
    Conserved Domains (5) summary
    cd00160
    Location:164 → 343
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13236
    Location:614 → 720
    PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus
    cd13387
    Location:375 → 482
    PH1_FGD3; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia protein 3, N-terminal Pleckstrin homology (PH) domain
    cd15740
    Location:535 → 588
    FYVE_FGD3; FYVE-like domain found in FYVE, RhoGEF and PH domain-containing protein 3 (FGD3) and similar proteins
    cl28033
    Location:1 → 148
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037335.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    84356368..84420638
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_059889036.1 → XP_059745019.1  FYVE, RhoGEF and PH domain-containing protein 3 isoform X1

    UniProtKB/TrEMBL
    A0AAF6DMH8

  2. XM_059889038.1 → XP_059745021.1  FYVE, RhoGEF and PH domain-containing protein 3 isoform X3

    UniProtKB/TrEMBL
    A0AAA9SV30, A0AAF6DMH8

  3. XM_005210429.5 → XP_005210486.1  FYVE, RhoGEF and PH domain-containing protein 3 isoform X1

    See identical proteins and their annotated locations for XP_005210486.1

    UniProtKB/TrEMBL
    A0AAF6DMH8
    Conserved Domains (5) summary
    cd13236
    Location:631 → 738
    PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus
    cd13387
    Location:392 → 499
    PH1_FGD3; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia protein 3, N-terminal Pleckstrin homology (PH) domain
    cd15740
    Location:552 → 605
    FYVE_FGD3; FYVE-like domain found in FYVE, RhoGEF and PH domain-containing protein 3 (FGD3) and similar proteins
    pfam00169
    Location:392 → 490
    PH; PH domain
    pfam00621
    Location:182 → 361
    RhoGEF; RhoGEF domain

  4. XM_059889037.1 → XP_059745020.1  FYVE, RhoGEF and PH domain-containing protein 3 isoform X2

    UniProtKB/TrEMBL
    A0AAA9TVP8, A0AAF6DMH8
    Related
    ENSBTAP00000101490.1, ENSBTAT00000100815.1

  5. XM_005210432.5 → XP_005210489.1  FYVE, RhoGEF and PH domain-containing protein 3 isoform X3

    See identical proteins and their annotated locations for XP_005210489.1

    UniProtKB/TrEMBL
    A0AAA9SV30, A0AAF6DMH8
    Related
    ENSBTAP00000087039.1, ENSBTAT00000107578.1
    Conserved Domains (5) summary
    cd00160
    Location:164 → 343
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13236
    Location:614 → 721
    PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus
    cd13387
    Location:375 → 482
    PH1_FGD3; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia protein 3, N-terminal Pleckstrin homology (PH) domain
    cd15740
    Location:535 → 588
    FYVE_FGD3; FYVE-like domain found in FYVE, RhoGEF and PH domain-containing protein 3 (FGD3) and similar proteins
    cl28033
    Location:1 → 148
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
Nucleotide Protein Strain
Heading Accession and Version

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