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ERGIC2 ERGIC and golgi 2 [ Homo sapiens (human) ]

Gene ID: 51290, updated on 11-Sep-2019

Summary

Official Symbol
ERGIC2provided by HGNC
Official Full Name
ERGIC and golgi 2provided by HGNC
Primary source
HGNC:HGNC:30208
See related
Ensembl:ENSG00000087502 MIM:612236
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PTX1; CDA14; Erv41; cd002
Summary
ERGIC2, or PTX1, is a ubiquitously expressed nuclear protein that is downregulated in prostate carcinoma (Kwok et al., 2001 [PubMed 11445006]).[supplied by OMIM, Aug 2008]
Expression
Ubiquitous expression in urinary bladder (RPKM 7.7), placenta (RPKM 7.5) and 25 other tissues See more
Orthologs

Genomic context

See ERGIC2 in Genome Data Viewer
Location:
12p11.22
Exon count:
16
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (29336544..29381172, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (29493579..29534143, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928735 Neighboring gene fatty acyl-CoA reductase 2 Neighboring gene uncharacterized LOC100506606 Neighboring gene OVCH1 antisense RNA 1 Neighboring gene ovochymase 1 Neighboring gene uncharacterized LOC105369714 Neighboring gene transmembrane O-mannosyltransferase targeting cadherins 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with ERGIC2; predicted interaction to be within the endoplasmic reticulum to Golgi transport PubMed
env HIV-1 gp160 is identified to have a physical interaction with ERGIC and golgi 2 (ERGIC2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC111152

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
ER to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
retrograde vesicle-mediated transport, Golgi to ER IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
retrograde vesicle-mediated transport, Golgi to ER IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
COPII-coated ER to Golgi transport vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum-Golgi intermediate compartment membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
membrane HDA PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
endoplasmic reticulum-Golgi intermediate compartment protein 2
Names
CD14 protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016570.3NP_057654.2  endoplasmic reticulum-Golgi intermediate compartment protein 2

    See identical proteins and their annotated locations for NP_057654.2

    Status: VALIDATED

    Source sequence(s)
    AC009318, AL834128, BC000887, BF681475, BU675240
    Consensus CDS
    CCDS41765.1
    UniProtKB/Swiss-Prot
    Q96RQ1
    UniProtKB/TrEMBL
    A0A024RB08, Q86TD3
    Related
    ENSP00000353270.4, ENST00000360150.9
    Conserved Domains (2) summary
    pfam07970
    Location:170332
    COPIIcoated_ERV; Endoplasmic reticulum vesicle transporter
    pfam13850
    Location:1395
    ERGIC_N; Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    29336544..29381172 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024449009.1XP_024304777.1  endoplasmic reticulum-Golgi intermediate compartment protein 2 isoform X1

    Conserved Domains (2) summary
    pfam07970
    Location:170332
    COPIIcoated_ERV; Endoplasmic reticulum vesicle transporter
    pfam13850
    Location:1395
    ERGIC_N; Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)

RNA

  1. XR_001748741.2 RNA Sequence

  2. XR_001748740.2 RNA Sequence

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