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CDK18 cyclin dependent kinase 18 [ Homo sapiens (human) ]

Gene ID: 5129, updated on 4-Dec-2022

Summary

Official Symbol
CDK18provided by HGNC
Official Full Name
cyclin dependent kinase 18provided by HGNC
Primary source
HGNC:HGNC:8751
See related
Ensembl:ENSG00000117266 MIM:169190; AllianceGenome:HGNC:8751
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PCTK3; PCTAIRE; PCTAIRE3
Summary
Predicted to enable ATP binding activity; cyclin-dependent protein serine/threonine kinase activity; and protein serine kinase activity. Predicted to be involved in protein phosphorylation and regulation of transcription involved in G1/S transition of mitotic cell cycle. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in heart (RPKM 26.3), brain (RPKM 20.4) and 20 other tissues See more
Orthologs
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Genomic context

See CDK18 in Genome Data Viewer
Location:
1q32.1
Exon count:
17
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (205504669..205532790)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (204769067..204797187)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (205473797..205501918)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene LEMD1 divergent transcript Neighboring gene tRNA-Lys (TTT) 8-1 Neighboring gene Sharpr-MPRA regulatory region 5902 Neighboring gene MFSD4A antisense RNA 1 Neighboring gene RNA, U2 small nuclear 19, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium.
EBI GWAS Catalog
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
EBI GWAS Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of cyclin-dependent kinase 18 (CDK18) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables cyclin-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription involved in G1/S transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
cyclin-dependent kinase 18
Names
PCTAIRE protein kinase 3
PCTAIRE-motif protein kinase 3
cell division protein kinase 18
serine/threonine-protein kinase PCTAIRE-3
NP_002587.2
NP_997667.1
NP_997668.1
XP_011507904.2
XP_016856912.2
XP_047278158.1
XP_047278159.1
XP_047278163.1
XP_047278165.1
XP_047278166.1
XP_047278168.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002596.4NP_002587.2  cyclin-dependent kinase 18 isoform b

    See identical proteins and their annotated locations for NP_002587.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding region compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 2 and 3 both encode isoform b.
    Source sequence(s)
    AL357131, KF455139
    Consensus CDS
    CCDS44300.1
    UniProtKB/Swiss-Prot
    Q07002, Q96F90
    UniProtKB/TrEMBL
    A0A024R996, Q59G02
    Related
    ENSP00000353176.2, ENST00000360066.6
    Conserved Domains (1) summary
    cd07871
    Location:138425
    STKc_PCTAIRE3; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-3 kinase
  2. NM_212502.3NP_997667.1  cyclin-dependent kinase 18 isoform b

    See identical proteins and their annotated locations for NP_997667.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in a coding exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 2 and 3 both encode isoform b.
    Source sequence(s)
    AB209307, AY353237, BM695474
    Consensus CDS
    CCDS44300.1
    UniProtKB/Swiss-Prot
    Q07002, Q96F90
    UniProtKB/TrEMBL
    A0A024R996, Q59G02
    Related
    ENSP00000399082.2, ENST00000429964.7
    Conserved Domains (1) summary
    cd07871
    Location:138425
    STKc_PCTAIRE3; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-3 kinase
  3. NM_212503.3NP_997668.1  cyclin-dependent kinase 18 isoform a

    See identical proteins and their annotated locations for NP_997668.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AL357131, KF455139
    Consensus CDS
    CCDS1454.1
    UniProtKB/Swiss-Prot
    Q07002
    UniProtKB/TrEMBL
    A0A024R980, Q59G02
    Related
    ENSP00000423665.1, ENST00000506784.5
    Conserved Domains (2) summary
    PLN00009
    Location:171459
    PLN00009; cyclin-dependent kinase A; Provisional
    cd07871
    Location:168455
    STKc_PCTAIRE3; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-3 kinase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    205504669..205532790
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047422207.1XP_047278163.1  cyclin-dependent kinase 18 isoform X1

  2. XM_047422212.1XP_047278168.1  cyclin-dependent kinase 18 isoform X3

  3. XM_017001423.3XP_016856912.2  cyclin-dependent kinase 18 isoform X2

    UniProtKB/TrEMBL
    A0A024R980
  4. XM_011509602.4XP_011507904.2  cyclin-dependent kinase 18 isoform X4

    UniProtKB/Swiss-Prot
    Q96F90
    UniProtKB/TrEMBL
    A0A024R996
  5. XM_047422209.1XP_047278165.1  cyclin-dependent kinase 18 isoform X1

  6. XM_047422210.1XP_047278166.1  cyclin-dependent kinase 18 isoform X1

  7. XM_047422202.1XP_047278158.1  cyclin-dependent kinase 18 isoform X1

  8. XM_047422203.1XP_047278159.1  cyclin-dependent kinase 18 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    204769067..204797187
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)