U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

RXFP3 relaxin family peptide receptor 3 [ Homo sapiens (human) ]

Gene ID: 51289, updated on 22-Sep-2022

Summary

Official Symbol
RXFP3provided by HGNC
Official Full Name
relaxin family peptide receptor 3provided by HGNC
Primary source
HGNC:HGNC:24883
See related
Ensembl:ENSG00000182631 MIM:609445; AllianceGenome:HGNC:24883
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SALPR; RLN3R1; RXFPR3; GPCR135
Summary
Predicted to enable G protein-coupled peptide receptor activity. Involved in positive regulation of cytokinesis. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See RXFP3 in Genome Data Viewer
Location:
5p13.2
Exon count:
1
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (33936386..33938918)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (34058309..34060841)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (33936491..33939023)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 12 Neighboring gene ST3GAL5 pseudogene 1 Neighboring gene RNA, U6 small nuclear 923, pseudogene Neighboring gene C1QTNF3-AMACR readthrough (NMD candidate) Neighboring gene solute carrier family 45 member 2 Neighboring gene proteasome 26S subunit, ATPase, 6 pseudogene 3 Neighboring gene alpha-methylacyl-CoA racemase

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC141998, MGC142000

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables G protein-coupled receptor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
relaxin-3 receptor 1
Names
G-protein coupled receptor GPCR135
G-protein coupled receptor SALPR
RLN3 receptor 1
g protein-coupled receptor SALPR
relaxin/insulin like family peptide receptor 3
somatostatin and angiotensin-like peptide receptor

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016568.3NP_057652.1  relaxin-3 receptor 1

    See identical proteins and their annotated locations for NP_057652.1

    Status: VALIDATED

    Source sequence(s)
    AC139777, BC113438, D88437
    Consensus CDS
    CCDS3900.1
    UniProtKB/Swiss-Prot
    Q14DA5, Q9NSD7
    Related
    ENSP00000328708.3, ENST00000330120.5
    Conserved Domains (1) summary
    pfam00001
    Location:98389
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    33936386..33938918
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187551.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    137708..140240
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    34058309..34060841
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)