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RXFP3 relaxin family peptide receptor 3 [ Homo sapiens (human) ]

Gene ID: 51289, updated on 17-Sep-2024

Summary

Official Symbol
RXFP3provided by HGNC
Official Full Name
relaxin family peptide receptor 3provided by HGNC
Primary source
HGNC:HGNC:24883
See related
Ensembl:ENSG00000182631 MIM:609445; AllianceGenome:HGNC:24883
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SALPR; RLN3R1; RXFPR3; GPCR135
Summary
Predicted to enable G protein-coupled peptide receptor activity. Involved in positive regulation of cytokinesis. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See RXFP3 in Genome Data Viewer
Location:
5p13.2
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (33936386..33938918)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (34058309..34060841)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (33936491..33939023)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 12 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22456 Neighboring gene ST3GAL5 pseudogene 1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:33788320-33789519 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:33850007-33850508 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:33891377-33891878 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:33891879-33892378 Neighboring gene RNA, U6 small nuclear 923, pseudogene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:33931143-33931648 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:33944338-33944838 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:33944839-33945339 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:33978101-33978993 Neighboring gene C1QTNF3-AMACR readthrough (NMD candidate) Neighboring gene solute carrier family 45 member 2 Neighboring gene proteasome 26S subunit, ATPase, 6 pseudogene 3 Neighboring gene alpha-methylacyl-CoA racemase

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
relaxin-3 receptor 1
Names
G-protein coupled receptor GPCR135
G-protein coupled receptor SALPR
RLN3 receptor 1
g protein-coupled receptor SALPR
relaxin/insulin like family peptide receptor 3
somatostatin and angiotensin-like peptide receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016568.3NP_057652.1  relaxin-3 receptor 1

    See identical proteins and their annotated locations for NP_057652.1

    Status: VALIDATED

    Source sequence(s)
    AC139777, BC113438, D88437
    Consensus CDS
    CCDS3900.1
    UniProtKB/Swiss-Prot
    Q14DA5, Q9NSD7
    UniProtKB/TrEMBL
    Q502V2
    Related
    ENSP00000328708.3, ENST00000330120.5
    Conserved Domains (1) summary
    pfam00001
    Location:98389
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    33936386..33938918
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187551.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    137708..140240
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    34058309..34060841
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)