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RASL12 RAS like family 12 [ Homo sapiens (human) ]

Gene ID: 51285, updated on 1-Jun-2020

Summary

Official Symbol
RASL12provided by HGNC
Official Full Name
RAS like family 12provided by HGNC
Primary source
HGNC:HGNC:30289
See related
Ensembl:ENSG00000103710
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RIS
Expression
Broad expression in prostate (RPKM 19.4), endometrium (RPKM 17.1) and 21 other tissues See more
Orthologs

Genomic context

See RASL12 in Genome Data Viewer
Location:
15q22.31
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (65045576..65076704, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (65337919..65360707, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene SPG21 abhydrolase domain containing, maspardin Neighboring gene mitochondrial methionyl-tRNA formyltransferase Neighboring gene transmembrane protein 126A pseudogene Neighboring gene solute carrier family 51 subunit beta Neighboring gene kelch repeat and BTB domain containing 13 Neighboring gene ubiquitin associated protein 1 like

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GDP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ras-like protein family member 12
Names
Ras family member Ris
ras-like protein Ris

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001307930.2NP_001294859.1  ras-like protein family member 12 isoform 2

    See identical proteins and their annotated locations for NP_001294859.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC013553, AF233588, AK296261, BI489884
    Consensus CDS
    CCDS76769.1
    UniProtKB/Swiss-Prot
    Q9NYN1
    Related
    ENSP00000390028.3, ENST00000421977.7
    Conserved Domains (2) summary
    smart00173
    Location:23166
    RAS; Ras subfamily of RAS small GTPases
    cl21455
    Location:22166
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. NM_001379429.1NP_001366358.1  ras-like protein family member 12 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC013553
  3. NM_016563.4NP_057647.1  ras-like protein family member 12 isoform 1

    See identical proteins and their annotated locations for NP_057647.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC013553, AF233588, BI489884
    Consensus CDS
    CCDS10200.1
    UniProtKB/Swiss-Prot
    Q9NYN1
    UniProtKB/TrEMBL
    A0A024R5Y3
    Related
    ENSP00000220062.4, ENST00000220062.9
    Conserved Domains (1) summary
    cd04146
    Location:22185
    RERG_RasL11_like; Ras-related and Estrogen-Regulated Growth inhibitor (RERG) and Ras-like 11 (RasL11)-like families

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    65045576..65076704 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005254434.4XP_005254491.1  ras-like protein family member 12 isoform X3

    Conserved Domains (1) summary
    cl21455
    Location:22142
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. XM_017022296.1XP_016877785.1  ras-like protein family member 12 isoform X2

  3. XM_011521660.3XP_011519962.1  ras-like protein family member 12 isoform X1

    Related
    ENSP00000412787.2, ENST00000434605.2
    Conserved Domains (2) summary
    smart00173
    Location:27180
    RAS; Ras subfamily of RAS small GTPases
    cl21455
    Location:27180
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
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