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RASL12 RAS like family 12 [ Homo sapiens (human) ]

Gene ID: 51285, updated on 19-Sep-2024

Summary

Official Symbol
RASL12provided by HGNC
Official Full Name
RAS like family 12provided by HGNC
Primary source
HGNC:HGNC:30289
See related
Ensembl:ENSG00000103710 AllianceGenome:HGNC:30289
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RIS
Summary
Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Predicted to be involved in signal transduction. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in prostate (RPKM 19.4), endometrium (RPKM 17.1) and 21 other tissues See more
Orthologs
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Genomic context

See RASL12 in Genome Data Viewer
Location:
15q22.31
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (65045580..65076667, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (62855016..62886085, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (65345675..65369005, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene SPG21 abhydrolase domain containing, maspardin Neighboring gene H3K27ac hESC enhancers GRCh37_chr15:65281459-65281960 and GRCh37_chr15:65281961-65282460 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9589 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9590 Neighboring gene mitochondrial methionyl-tRNA formyltransferase Neighboring gene transmembrane protein 126A pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6549 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6550 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9591 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:65346770-65347270 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:65347271-65347771 Neighboring gene SLC51 subunit beta Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:65363995-65364494 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:65377155-65377680 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:65378209-65378734 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9592 Neighboring gene kelch repeat and BTB domain containing 13 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:65379400-65380041 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:65385262-65385762 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:65386379-65386880 Neighboring gene ubiquitin associated protein 1 like

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein activity IEA
Inferred from Electronic Annotation
more info
 
enables GDP binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
ras-like protein family member 12
Names
Ras family member Ris
ras-like protein Ris
NP_001294859.1
NP_001366358.1
NP_057647.1
XP_005254491.1
XP_011519962.1
XP_016877785.1
XP_054234136.1
XP_054234137.1
XP_054234138.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001307930.2NP_001294859.1  ras-like protein family member 12 isoform 2

    See identical proteins and their annotated locations for NP_001294859.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC013553, AF233588, AK296261, BI489884
    Consensus CDS
    CCDS76769.1
    UniProtKB/Swiss-Prot
    Q9NYN1
    Related
    ENSP00000390028.3, ENST00000421977.7
    Conserved Domains (2) summary
    smart00173
    Location:23166
    RAS; Ras subfamily of RAS small GTPases
    cl21455
    Location:22166
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. NM_001379429.1NP_001366358.1  ras-like protein family member 12 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC013553
    Consensus CDS
    CCDS92017.1
    Related
    ENSP00000412787.2, ENST00000434605.2
    Conserved Domains (1) summary
    cl38936
    Location:24174
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  3. NM_016563.4NP_057647.1  ras-like protein family member 12 isoform 1

    See identical proteins and their annotated locations for NP_057647.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC013553, AF233588, BI489884
    Consensus CDS
    CCDS10200.1
    UniProtKB/Swiss-Prot
    B2RC29, B4DJW2, B4DU82, Q9NYN1
    Related
    ENSP00000220062.4, ENST00000220062.9
    Conserved Domains (1) summary
    cd04146
    Location:22185
    RERG_RasL11_like; Ras-related and Estrogen-Regulated Growth inhibitor (RERG) and Ras-like 11 (RasL11)-like families

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    65045580..65076667 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005254434.5XP_005254491.1  ras-like protein family member 12 isoform X3

    Conserved Domains (1) summary
    cl21455
    Location:22142
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. XM_017022296.2XP_016877785.1  ras-like protein family member 12 isoform X2

  3. XM_011521660.4XP_011519962.1  ras-like protein family member 12 isoform X1

    Conserved Domains (2) summary
    smart00173
    Location:27180
    RAS; Ras subfamily of RAS small GTPases
    cl21455
    Location:27180
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    62855016..62886085 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054378163.1XP_054234138.1  ras-like protein family member 12 isoform X3

  2. XM_054378162.1XP_054234137.1  ras-like protein family member 12 isoform X2

  3. XM_054378161.1XP_054234136.1  ras-like protein family member 12 isoform X1