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SCAND1 SCAN domain containing 1 [ Homo sapiens (human) ]

Gene ID: 51282, updated on 5-Jul-2025
Official Symbol
SCAND1provided by HGNC
Official Full Name
SCAN domain containing 1provided by HGNC
Primary source
HGNC:HGNC:10566
See related
Ensembl:ENSG00000171222 MIM:610416; AllianceGenome:HGNC:10566
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RAZ1; SDP1
Summary
This gene encodes a SCAN box domain-containing protein. The SCAN domain is a highly conserved, leucine-rich motif of approximately 60 aa originally found within a subfamily of zinc finger proteins. This gene belongs to a family of genes that encode an isolated SCAN domain, but no zinc finger motif. This protein binds to and may regulate the function of the transcription factor myeloid zinc finger 1B. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jan 2011]
Expression
Ubiquitous expression in kidney (RPKM 14.6), fat (RPKM 13.5) and 25 other tissues See more
Orthologs
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See SCAND1 in Genome Data Viewer
Location:
20q11.23
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (35953624..35959472, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (37674621..37680469, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (34541546..34547394, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene PHD finger protein 20 Neighboring gene RNA, U4 small nuclear 40, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:34494545-34495045 Neighboring gene RNA, U6 small nuclear 937, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17799 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17800 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17801 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17802 Neighboring gene uncharacterized LOC124904982 Neighboring gene cyclic nucleotide binding domain containing 2 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr20:34637879-34639078 Neighboring gene non-coding RNA activated by DNA damage

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Characterization of the SCAN box encoding RAZ1 gene: analysis of cDNA transcripts, expression, and cellular localization. Sander TL, et al. Gene, 2002 Aug 21. PMID 12383503
  2. SCAND1 Reverses Epithelial-to-Mesenchymal Transition (EMT) and Suppresses Prostate Cancer Growth and Migration. Eguchi T, et al. Cells, 2022 Dec 10. PMID 36552758, Free PMC Article
  3. The SCAN domain mediates selective oligomerization. Schumacher C, et al. J Biol Chem, 2000 Jun 2. PMID 10747874
  4. Identification of a novel SCAN box-related protein that interacts with MZF1B. The leucine-rich SCAN box mediates hetero- and homoprotein associations. Sander TL, et al. J Biol Chem, 2000 Apr 28. PMID 10777584
  5. SDP1 is a peroxisome-proliferator-activated receptor gamma 2 co-activator that binds through its SCAN domain. Babb R, et al. Biochem J, 2003 Mar 1. PMID 12444922, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SCAND1 Reverses Epithelial-to-Mesenchymal Transition (EMT) and Suppresses Prostate Cancer Growth and Migration.
    Title: SCAND1 Reverses Epithelial-to-Mesenchymal Transition (EMT) and Suppresses Prostate Cancer Growth and Migration.
  2. Observational study of gene-disease association. (HuGE Navigator)
    Title: Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.
  3. This result indicates that NY-REN-21 can function either as a homodimer or as a heterodimer with SCAND1.
    Title: Spectroscopic characterization of the tumor antigen NY-REN-21 and identification of heterodimer formation with SCAND1.
Submit: New GeneRIF Correction

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
SCAN domain-containing protein 1
Names
SCAN-related protein RAZ1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001385710.1 → NP_001372639.1  SCAN domain-containing protein 1

    Status: REVIEWED

    Source sequence(s)
    AL109965
    Consensus CDS
    CCDS13269.1
    UniProtKB/Swiss-Prot
    P57086, Q6IAG7
    UniProtKB/TrEMBL
    Q9NZG6
    Related
    ENSP00000363103.3, ENST00000373991.3
    Conserved Domains (1) summary
    pfam02023
    Location:104 → 162
    SCAN; SCAN domain

  2. NM_016558.4 → NP_057642.1  SCAN domain-containing protein 1

    See identical proteins and their annotated locations for NP_057642.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes isoform 1.
    Source sequence(s)
    AF207829, AL109965, BU848795
    Consensus CDS
    CCDS13269.1
    UniProtKB/Swiss-Prot
    P57086, Q6IAG7
    UniProtKB/TrEMBL
    Q9NZG6
    Related
    ENSP00000481289.1, ENST00000615116.1
    Conserved Domains (1) summary
    pfam02023
    Location:104 → 162
    SCAN; SCAN domain

  3. NM_033630.3 → NP_361012.3  SCAN domain-containing protein 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and contains an extra segment in the 5' coding region, compared to variant 1. These differences cause translation initiation at an upstream start codon, compared to variant 1. The encoded protein (isoform 2) has a longer N-terminus, compared to isoform 1.
    Source sequence(s)
    AL109965
    UniProtKB/Swiss-Prot
    P57086, Q6IAG7
    UniProtKB/TrEMBL
    Q9NZG6
    Related
    ENSP00000301995.2, ENST00000305978.7
    Conserved Domains (1) summary
    pfam02023
    Location:104 → 162
    SCAN; SCAN domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    35953624..35959472 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    37674621..37680469 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P57086.1 GenPept UniProtKB/Swiss-Prot:P57086

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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